INT61259

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 11.11
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
microglia 4
neutrophils 4
neurons 2
macrophages 1
monocytes 1
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 347 100.00 Very High Very High Very High
Inflammatory mediators 20 100.00 Very High Very High Very High
midbrain 49 99.08 Very High Very High Very High
agonist 43 97.76 Very High Very High Very High
cINOD 120 91.64 High High
Dopamine 88 91.52 High High
Inflammatory response 72 90.96 High High
cytokine 191 89.08 High High
chemokine 5 88.28 High High
glial activation 8 79.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 466 100.00 Very High Very High Very High
Asthma 40 99.82 Very High Very High Very High
Infection 332 99.52 Very High Very High Very High
Adhesions 15 97.64 Very High Very High Very High
Disease 360 96.24 Very High Very High Very High
Death 34 95.24 Very High Very High Very High
Metabolic Syndrome 12 94.64 High High
Injury 65 93.56 High High
Meningitis 179 92.28 High High
Leukemia 3 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In keeping with these findings, genetic or pharmacological inhibition of most inflammatory factors, including iNOS, PHOX, Mac-1 and COX-2-derived mediators, significantly attenuated DAergic degeneration in experimental models of PD [27-44].
Negative_regulation (inhibition) of Mac-1 associated with inflammation and disease
1) Confidence 0.47 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.49 Pain Relevance 0.48
In patients treated with quinapril and irbesartan, but not placebo, there was a significant reduction in soluble interleukin-6 (sIL-6) and CD11b receptor (Lauten et al 2003).
Negative_regulation (reduction) of CD11b
2) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.31 Pain Relevance 0.03
However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19.
Negative_regulation (decreased) of CD11b
3) Confidence 0.39 Published 2010 Journal Nutr Cancer Section Abstract Doc Link 20574920 Disease Relevance 0.65 Pain Relevance 0.07
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
Negative_regulation (inhibiting) of Mac-1 in neutrophil associated with inflammation
4) Confidence 0.36 Published 1996 Journal Eur. J. Immunol. Section Title Doc Link 8566054 Disease Relevance 0.88 Pain Relevance 0.39
HCT1026-induced neuroprotection observed in the present study was accompanied by a sharp downregulation of all studied markers of microglial activation including ameboid-like microglial cell number, pro-inflammatory mediators as well as two key harmfull elements, MAC-1 and PHOX, likely suggesting that a shift from microglial pro-inflammatory ("harmfull") phenotype might be a major contributing factor.
Negative_regulation (downregulation) of MAC-1 in microglial cell associated with inflammatory mediators and inflammation
5) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.07 Pain Relevance 0.44
These effects were associated to a significant decrease in reactive macrophage antigen-1 (Mac-1)-positive microglial cells within the striatum and ventral midbrain, decreased expression of iNOS, Mac-1 and NADPH oxidase (PHOX), and downregulation of 3-Nitrotyrosine, a peroxynitrite finger print, in SNpc DAergic neurons.


Negative_regulation (decrease) of Mac-1 in microglial cells associated with midbrain
6) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3000390 Disease Relevance 0.72 Pain Relevance 0.24
In addition, the mitigation of the nitrosative/oxidative status of the nigral microenvironment as revealed by downregulation of Mac-1, PHOX and 3-NT in the VM, likely have beneficial consequences for glial expression of critical neuroprotective/neurotrophic factors [18], thereby supporting TH+ neuron survival/neurorescue, possibly through an amelioration/mitigation of SNpc nicroenvironment.
Negative_regulation (downregulation) of Mac-1 in neuron associated with midbrain
7) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.73 Pain Relevance 0.28
However, mice deficient in CR3 have been developed and found to have normal migration of neutrophils in the peritoneal cavity after chemical and TNF stimulus (Lu et al., 1997).
Negative_regulation (deficient) of CR3 in neutrophils
8) Confidence 0.26 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.57 Pain Relevance 0.11
Although neurons and microglia can still be clearly detected after 6 hours of pMCAO [12,14], the developing infarct is usually characterised by severe cell loss 12 hours after pMCAO [12,14,20] We were therefore surprised not to observe a reduction in the number of CD11b+CD45dim microglia 12 and 24 hours after pMCAO.
Negative_regulation (reduction) of CD11b in neurons
9) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0.07
of asthma through suppression of IL-13, IL-5, IgE, eosinophils CCR3 expression, and CD11b
Negative_regulation (suppression) of CD11b in eosinophils associated with asthma
10) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.79 Pain Relevance 0.07
In agreement, histopathological sections of brains of CR3 knocked down and infected mice also exhibited neutrophil infiltration similar to that of WT-infected mice, indicating neutrophil migration is not defective in CR3-suppressed mice.
Neg (not) Negative_regulation (defective) of CR3-suppressed in neutrophil
11) Confidence 0.22 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.73 Pain Relevance 0.03
After 24 h, there was a decrease of AMs (CD11c+CD11b?
Negative_regulation (decrease) of CD11b
12) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.78 Pain Relevance 0.03
0.9) and strongly negatively correlated with the number of Mac-1-stained reactive microglia and with the level of COX-2 (rs ?
Negative_regulation (number) of Mac-1-stained in microglia
13) Confidence 0.17 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.17 Pain Relevance 0.19
Also, myeloid cell–specific genes including CD11b, RANK, and DAP12 are reduced in the MDL-1–Ig fusion group and elevated in anti–MDL-1 agonist group.
Negative_regulation (reduced) of CD11b in myeloid cell associated with agonist
14) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.43 Pain Relevance 0.30
RIa and CR3 was significantly reduced, while TLR2 and TLR4 expression was unaltered (Figure 3B).
Negative_regulation (reduced) of CR3
15) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0 Pain Relevance 0
Our studies also demonstrated that the IL-10–induced bactericidal activity of neutrophils and macrophages is caused by increased expression of CR3 and TLR4, which was suppressed during the infection without treatment.
Negative_regulation (suppressed) of CR3 in neutrophils associated with infection
16) Confidence 0.13 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.67 Pain Relevance 0.16
Interestingly, green tea polyphenols and unripened apple polyphenols appear to downregulate CD11b on bovine peripheral monocytes, suggesting that leukocyte adhesion and migration mediated in part by CD11b/CD18 could be inhibited after treatment with these compounds.
Negative_regulation (downregulate) of CD11b in monocytes associated with adhesions
17) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.46 Pain Relevance 0.13
Although neurons and microglia can still be clearly detected after 6 hours of pMCAO [12,14], the developing infarct is usually characterised by severe cell loss 12 hours after pMCAO [12,14,20] We were therefore surprised not to observe a reduction in the number of CD11b+CD45dim microglia 12 and 24 hours after pMCAO.
Negative_regulation (reduction) of CD11b in microglia
18) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0.07
Our studies also demonstrated that the IL-10–induced bactericidal activity of neutrophils and macrophages is caused by increased expression of CR3 and TLR4, which was suppressed during the infection without treatment.
Negative_regulation (suppressed) of CR3 in macrophages associated with infection
19) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.67 Pain Relevance 0.16

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