INT6126

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 7.72
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Ahsp) cytoplasm (Ahsp)
Anatomy Link Frequency
endothelium 4
joint 2
endothelial cells 2
myocyte 1
vessels 1
Ahsp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Migraine 12 99.60 Very High Very High Very High
Calcium channel 1 99.28 Very High Very High Very High
anesthesia 7 98.52 Very High Very High Very High
ischemia 5 98.12 Very High Very High Very High
Clonidine 3 97.34 Very High Very High Very High
Paracetamol 103 97.32 Very High Very High Very High
b2 receptor 3 96.88 Very High Very High Very High
Serotonin 3 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 33 100.00 Very High Very High Very High
Headache 14 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 15 99.46 Very High Very High Very High
Disease 5 99.24 Very High Very High Very High
Cv Unclassified Under Development 8 99.00 Very High Very High Very High
Hypotension 12 98.72 Very High Very High Very High
Coronary Artery Disease 3 98.12 Very High Very High Very High
Injury 4 98.02 Very High Very High Very High
Necrosis 15 96.92 Very High Very High Very High
Toxicity 43 96.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that chronic EtOH consumption significantly potentiates alpha-adrenergic-induced contractions in rat aortic rings, probably through interference with the production and/or the release of EDRF.
Gene_expression (production) of EDRF
1) Confidence 0.67 Published 1992 Journal Gen. Pharmacol. Section Abstract Doc Link 1322338 Disease Relevance 0.08 Pain Relevance 0.06
It has been suggested that these toxicity pattern may be associated with paracetamol metabolite and free radical NAPQI, resulting in myocyte glutathione depletion, damage to the myocardium and breakdown of endothelium-derived vascular relaxing factor (EDRF), leading to functional coronary insufficiency [33] and myocyte coagulative necrosis which has been observed in our study and in previous ones [52].
Gene_expression (derived) of EDRF in myocyte associated with necrosis, toxicity, paracetamol and cv unclassified under development
2) Confidence 0.65 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 1.60 Pain Relevance 0.64
Alterations in vasoreactivity observed during surgical manipulation, trauma, inhalational anesthesia, atherosclerosis, and other disease states can now be explained by their influence on the endothelial cells and EDRF.
Gene_expression (influence) of EDRF in endothelial cells associated with anesthesia, injury, disease and increased venous pressure under development
3) Confidence 0.59 Published 1988 Journal J Clin Anesth Section Abstract Doc Link 3078530 Disease Relevance 0.30 Pain Relevance 0.10
These data demonstrate that compounds such as BAEE generate an EDRF-like agent in vivo and basic amino acids such as L-arginine elicit hypotension at concentrations above 100 mg/kg by mechanisms other than the generation of EDRF.
Gene_expression (generation) of EDRF associated with hypotension
4) Confidence 0.49 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1602391 Disease Relevance 0.61 Pain Relevance 0
The endothelial cells produce one or more endothelium derived relaxing factor(s) or EDRF that cause relaxation of vascular smooth muscle cells through production of cyclic guanosine monophosphate (GMP) and subsequent activation of protein kinase.
Gene_expression (produce) of EDRF in smooth muscle cells
5) Confidence 0.46 Published 1988 Journal J Clin Anesth Section Abstract Doc Link 3078530 Disease Relevance 0.18 Pain Relevance 0.06
Inhibition of nitric oxide endothelium-derived relaxing factor (EDRF) synthesis with NG-monomethyl-L-arginine (MeArg, 1 mg kg-1 min-1 i.v. for 30 min) produced an increase in MAP and largely attenuated the LPS-induced hypotension; both effects were significantly reversed with L-arginine (6 mg kg-1 min-1 i.v.).
Gene_expression (synthesis) of EDRF in endothelium associated with hypotension
6) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226626 Disease Relevance 0.17 Pain Relevance 0
This exercise-induced vasoconstriction has been associated with the occurrence of myocardial ischemia and has been believed to be the result of endothelial dysfunction, with a reduced release or production of EDRF, increased sympathetic stimulation, enhanced platelet aggregation with release of thromboxane A2 and serotonin, or a passive collapse of the disease-free wall segment within the stenosis (the Bernoulli effect), or a combination of any of these.
Gene_expression (production) of EDRF in platelet associated with pathologic constriction, coronary artery disease, ischemia, shock, disease, increased venous pressure under development and serotonin
7) Confidence 0.22 Published 2000 Journal Coron. Artery Dis. Section Abstract Doc Link 10860181 Disease Relevance 0.74 Pain Relevance 0.23
L-NA induces an increase in calcium entry through receptor modulated calcium channels, and because the inhibition of the synthesis of EDRF it would produce an increase in vascular tension.
Gene_expression (synthesis) of EDRF associated with calcium channel
8) Confidence 0.22 Published 1996 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9222395 Disease Relevance 0 Pain Relevance 0.11
This mechanism is thought to be held in reserve to reinforce local production of prostacyclin and vasodilatation when cell damage to the endothelial lining occurs and EDRF-No is not produced.
Neg (not) Gene_expression (produced) of EDRF-No associated with increased venous pressure under development
9) Confidence 0.22 Published 1991 Journal Med. Clin. North Am. Section Abstract Doc Link 2020228 Disease Relevance 0.47 Pain Relevance 0.35
In addition, it produces endothelin-1 and angiotensin II; more importantly in the context of migraine, endothelial cells produce the vasodilators prostacyclin and EDRF-NO, both of which are local (paracrine) hormones.
Gene_expression (produce) of EDRF-NO in endothelial cells associated with migraine
10) Confidence 0.22 Published 1991 Journal Med. Clin. North Am. Section Abstract Doc Link 2020228 Disease Relevance 0.24 Pain Relevance 0.32
This impairment may be related to diminished EDRF/NO production or release in these vessels.
Gene_expression (production) of EDRF in vessels
11) Confidence 0.10 Published 1994 Journal Jpn. Circ. J. Section Abstract Doc Link 7966999 Disease Relevance 0.59 Pain Relevance 0.10
To clarify the involvement of the L-arginine-nitric oxide pathway in these alterations, we studied the effect of exogenous application of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF) and NG-nitro-L-arginine (NOLA), a competitive antagonist of the EDRF-producing enzyme on the vascular responses in vitro.
Gene_expression (producing) of EDRF in endothelium associated with antagonist
12) Confidence 0.09 Published 1992 Journal Circ. Shock Section Abstract Doc Link 1446389 Disease Relevance 0.70 Pain Relevance 0.51
To clarify the involvement of the L-arginine-nitric oxide pathway in these alterations, we studied the effect of exogenous application of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF) and NG-nitro-L-arginine (NOLA), a competitive antagonist of the EDRF-producing enzyme on the vascular responses in vitro.
Gene_expression (producing) of EDRF in endothelium associated with antagonist
13) Confidence 0.09 Published 1992 Journal Circ. Shock Section Abstract Doc Link 1446389 Disease Relevance 0.64 Pain Relevance 0.50
Kinins also stimulate the synthesis of other pro-inflammatory agents (PGs, LTs, histamine, EDRF, PGI2 and PAF) in the inflamed joint.
Gene_expression (synthesis) of EDRF in joint associated with inflammation
14) Confidence 0.06 Published 1991 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 1365470 Disease Relevance 0.54 Pain Relevance 0.45
The present investigation, using rabbit aortic rings precontracted with either norepinephrine or clonidine, was designed to determine whether captopril possesses an endothelium-dependent component of vasodilation related to its ability to protect endothelium-derived relaxing factor (EDRF) from superoxide-mediated destruction.
Gene_expression (protect) of EDRF in endothelium associated with increased venous pressure under development and clonidine
15) Confidence 0.06 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1646324 Disease Relevance 0.24 Pain Relevance 0.10
Kinins also stimulate the synthesis of other pro-inflammatory agents (PGs, LTs, histamine, EDRF, PGI2 and PAF) in the inflamed joint.
Gene_expression (synthesis) of EDRF in joint associated with inflammation
16) Confidence 0.05 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1648214 Disease Relevance 0.62 Pain Relevance 0.55

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