INT61262

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.25
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 6
granulocytes 2
myeloid cells 2
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 48 100.00 Very High Very High Very High
Acupuncture 57 99.28 Very High Very High Very High
Inflammation 63 97.40 Very High Very High Very High
rheumatoid arthritis 19 89.96 High High
cINOD 4 87.52 High High
Central nervous system 32 84.24 Quite High
Inflammatory response 5 72.96 Quite High
cytokine 19 68.80 Quite High
chemokine 10 64.16 Quite High
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 55 100.00 Very High Very High Very High
Infection 31 98.32 Very High Very High Very High
INFLAMMATION 53 97.40 Very High Very High Very High
Necrosis 3 94.60 High High
Cancer 4 94.24 High High
Immunization 13 91.88 High High
Rheumatoid Arthritis 19 89.96 High High
Disease 10 83.28 Quite High
Sprains And Strains 1 79.52 Quite High
Pneumonia 17 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also effectively blocks the upregulation of Mac-1 (CD11b/CD18) on neutrophils.
Negative_regulation (blocks) of Positive_regulation (upregulation) of CD11b/CD18 in neutrophils
1) Confidence 0.57 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.82 Pain Relevance 0.41
CD11b+/Gr1+ cell population in CIA mouse knee joint was also reduced significantly by EA at ST36, indicating that EA at ST36 reduced inflammatory granulocytes in CIA mouse knee joints (Data not shown).
Negative_regulation (reduced) of Positive_regulation (population) of CD11b in granulocytes associated with inflammation, acupuncture and arthritis
2) Confidence 0.41 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.94 Pain Relevance 1.01
It also effectively blocks the upregulation of Mac-1 (CD11b/CD18) on neutrophils.
Negative_regulation (blocks) of Positive_regulation (upregulation) of Mac-1 in neutrophils
3) Confidence 0.36 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.82 Pain Relevance 0.39
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Negative_regulation (shedding) of Positive_regulation (upregulation) of CD11b in neutrophils
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.13 Pain Relevance 0.04
In contrast, infiltrating CD11b and CD11c positive myeloid cells predominantly produced TLR11 protein, particularly early during infection at 1 wk post infection (~50% cells).
Negative_regulation (produced) of Positive_regulation (infiltrating) of CD11b in myeloid cells associated with infection
5) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.54 Pain Relevance 0.11

General Comments

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