INT6127

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 12
Speculated 5
Reported most in Abstract
Documents 60
Total Number 65
Disease Relevance 15.12
Pain Relevance 20.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 12
blood 12
posterior pituitary 4
cardiovascular system 4
ventricles 2
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 74 100.00 Very High Very High Very High
antagonist 67 100.00 Very High Very High Very High
fluoxetine 52 100.00 Very High Very High Very High
Serotonin 41 100.00 Very High Very High Very High
agonist 36 100.00 Very High Very High Very High
opiate 29 100.00 Very High Very High Very High
Opioid 26 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
Sumatriptan 19 100.00 Very High Very High Very High
Endogenous opioid 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 51 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 49 100.00 Very High Very High Very High
Hypoglycemia 27 100.00 Very High Very High Very High
Natriuresis 14 100.00 Very High Very High Very High
Hyponatremia 134 99.68 Very High Very High Very High
Stress 16 99.64 Very High Very High Very High
Syndrome 10 99.64 Very High Very High Very High
Hypertension 17 99.48 Very High Very High Very High
Obsessive-compulsive Disorder 17 99.48 Very High Very High Very High
Skin Cancer 3 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the cold pressor test on vasopressin secretion in man.
Regulation (effect) of Localization (secretion) of vasopressin associated with pain
1) Confidence 0.62 Published 1986 Journal Psychoneuroendocrinology Section Title Doc Link 3786636 Disease Relevance 0.18 Pain Relevance 0.18
We evaluated this claim by studying the effects of a modified cold pressor test on plasma AVP, plasma cortisol, blood pressure, pulse rate, and a number of variables known to affect AVP secretion.
Regulation (affect) of Localization (secretion) of AVP in blood
2) Confidence 0.62 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3786636 Disease Relevance 0.18 Pain Relevance 0.09
Noradrenaline (norepinephrine) has a complex effect on vasopressin secretion [49].
Regulation (effect) of Localization (secretion) of vasopressin associated with noradrenaline
3) Confidence 0.62 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.67 Pain Relevance 0.48
The central osmoreceptors that regulate vasopressin secretion are located near to the supraoptic nucleus in the anterolateral hypothalamus in a region with no blood–brain barrier [20].
Regulation (regulate) of Localization (secretion) of vasopressin in blood
4) Confidence 0.62 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.18 Pain Relevance 0
Naloxone-sensitive endogenous opioids do not seem to be involved in the control of basal and hypoglycemia-induced AVP secretion.
Regulation (control) of Localization (secretion) of AVP associated with hypoglycemia, endogenous opioid and narcan
5) Confidence 0.62 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2112727 Disease Relevance 0.57 Pain Relevance 0.67
The effect of a highly specific serotonin agonist on osmoregulated vasopressin secretion in healthy man.
Regulation (effect) of Localization (secretion) of vasopressin associated with agonist and serotonin
6) Confidence 0.61 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 1814657 Disease Relevance 0 Pain Relevance 0.29
OBJECTIVE: To explore a possible interaction of the serotonin neurotransmitter system and posterior pituitary function, we have looked at the effect of fluoxetine treatment on osmoregulated vasopressin secretion in normal men in two placebo controlled studies.
Regulation (effect) of Localization (secretion) of vasopressin in posterior pituitary associated with neurotransmitter, serotonin and fluoxetine
7) Confidence 0.61 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 1814657 Disease Relevance 0 Pain Relevance 0.27
The role of endogenous opioids in the control of vasopressin secretion was studied using the pure opiate antagonist naloxone.
Regulation (control) of Localization (secretion) of vasopressin associated with antagonist, narcan, endogenous opioid and opiate
8) Confidence 0.61 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.50
CONCLUSION: We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
Regulation (effect) of Localization (release) of vasopressin
9) Confidence 0.61 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1814657 Disease Relevance 0 Pain Relevance 0
Moreover, acute lowering of blood pressure facilitated the release of vasopressin and its osmoregulation while a chronic antihypertensive treatment did not interfere with a normal control of vasopressin secretion.
Regulation (control) of Localization (secretion) of vasopressin in blood
10) Confidence 0.61 Published 2003 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 14514019 Disease Relevance 0.30 Pain Relevance 0.06
The opiate control of vasopressin secretion in man was investigated with a long-acting analogue of met-enkephalin, DAMME (FK33-824, Sandoz).
Regulation (control) of Localization (secretion) of vasopressin associated with enkephalin and opiate
11) Confidence 0.60 Published 1980 Journal Lancet Section Abstract Doc Link 6107725 Disease Relevance 0.09 Pain Relevance 0.44
Metoclopramide has a striking influence on arginine vasopressin (AVP) secretion.
Regulation (influence) of Localization (secretion) of arginine vasopressin
12) Confidence 0.60 Published 2005 Journal Headache Section Abstract Doc Link 16324177 Disease Relevance 1.31 Pain Relevance 0.63
To test the influence of an opioid on vasopressin (AVP) secretion, plasma AVP concentration was measured in five semirecumbent unmedicated volunteers before and during two continuous i.v. infusions of fentanyl.
Regulation (influence) of Localization (secretion) of AVP in plasma associated with opioid
13) Confidence 0.60 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3116201 Disease Relevance 0 Pain Relevance 0.10
To determine the role of delta-opioid receptors in the modulation of hypothalamic-pituitary-adrenal activity, we studied in normal subjects the effect of the highly selective delta-opioid receptor agonist deltorphin (DT) on the secretion of ACTH, cortisol, and arginine vasopressin in response to insulin-induced hypoglycemia.
Regulation (effect) of Localization (secretion) of arginine vasopressin in pituitary associated with hypoglycemia, agonist, opioid receptor and delta opioid receptors
14) Confidence 0.60 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322422 Disease Relevance 0.31 Pain Relevance 0.28
The results suggest that in humans serotoninergic mechanisms, which modulate vasopressin secretion, do not involve the serotonin receptor activated by sumatriptan.
Regulation (modulate) of Localization (secretion) of vasopressin associated with sumatriptan and serotonin
15) Confidence 0.59 Published 1993 Journal Clin Neuropharmacol Section Abstract Doc Link 9377591 Disease Relevance 0 Pain Relevance 0.50
Sumatriptan does not affect vasopressin secretion in humans.
Neg (not) Regulation (affect) of Localization (secretion) of vasopressin associated with sumatriptan
16) Confidence 0.59 Published 1993 Journal Clin Neuropharmacol Section Title Doc Link 9377591 Disease Relevance 0 Pain Relevance 0.49
Effects of fentanyl on vasopressin secretion in human subjects.
Regulation (Effects) of Localization (secretion) of vasopressin
17) Confidence 0.59 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3116201 Disease Relevance 0 Pain Relevance 0.10
Studies were carried out in normal human subjects to determine the effect of two narcotic antagonists, oxilorphan and butorphanol, on antidiuretic hormone (ADH) release.
Regulation (effect) of Localization (release) of antidiuretic hormone associated with antagonist and butorphanol
18) Confidence 0.54 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6103008 Disease Relevance 0 Pain Relevance 0.28
The aim of the study was to investigate the effects of a new serotoninergic drug, sumatriptan, on arginine vasopressin secretion in humans.
Spec (investigate) Regulation (effects) of Localization (secretion) of vasopressin associated with sumatriptan
19) Confidence 0.52 Published 1993 Journal Clin Neuropharmacol Section Abstract Doc Link 9377591 Disease Relevance 0 Pain Relevance 0.45
Under normal conditions, AVP secretion is closely regulated to maintain body water homeostasis.
Regulation (regulated) of Localization (secretion) of AVP in body
20) Confidence 0.50 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.40 Pain Relevance 0

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