INT613

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2011
Negated 5
Speculated 9
Reported most in Abstract
Documents 268
Total Number 277
Disease Relevance 149.84
Pain Relevance 42.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
hepatocytes 18
plasma 18
liver 17
blood 15
body 5
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 160 100.00 Very High Very High Very High
anesthesia 114 100.00 Very High Very High Very High
amygdala 58 100.00 Very High Very High Very High
Restless leg syndrome 23 100.00 Very High Very High Very High
Analgesic 17 100.00 Very High Very High Very High
methotrexate 10 100.00 Very High Very High Very High
ischemia 186 99.98 Very High Very High Very High
Inflammation 545 99.92 Very High Very High Very High
lidocaine 23 99.92 Very High Very High Very High
halothane 113 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1210 100.00 Very High Very High Very High
Cancer 447 100.00 Very High Very High Very High
Pressure And Volume Under Development 278 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 226 100.00 Very High Very High Very High
Albuminuria 135 100.00 Very High Very High Very High
Pain 135 100.00 Very High Very High Very High
Coronary Artery Disease 129 100.00 Very High Very High Very High
Cv General 4 Under Development 70 100.00 Very High Very High Very High
Metastasis 64 100.00 Very High Very High Very High
Malignant Neoplastic Disease 62 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analbuminemic (NAR) rats which are Sprague-Dawley mutants with trace levels of plasma albumin due to a defect in albumin synthesis were studied.
Gene_expression (synthesis) of albumin in plasma
1) Confidence 0.78 Published 1987 Journal J. Surg. Res. Section Abstract Doc Link 3695456 Disease Relevance 0.86 Pain Relevance 0.13
Intact rats were also exposed to halothane, after which albumin synthesis was measured by the (14C)carbonate technique.
Gene_expression (synthesis) of albumin associated with halothane
2) Confidence 0.77 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.55
Halothane decreases albumin and transferrin synthesis: studies in the isolated, perfused rat liver and in the intact rat.
Gene_expression (synthesis) of albumin in liver associated with halothane
3) Confidence 0.77 Published 1988 Journal Anesthesiology Section Title Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.54
Similarly, reduction of albumin synthesis in intact rats immediately after a second halothane exposure may indicate a response to halothane, rather than to halothane metabolites.
Gene_expression (synthesis) of albumin associated with halothane
4) Confidence 0.77 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.09 Pain Relevance 0.82
Single exposures to halothane (groups II and III) resulted in a decrease in albumin synthesis immediately or 24 h later that did not differ significantly from controls (group I).
Gene_expression (synthesis) of albumin associated with halothane
5) Confidence 0.77 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.08 Pain Relevance 0.87
Isolated perfused rat livers exposed to 1.5% halothane (equivalent to 1.35 MAC) in O2/CO2 or to O2/CO2 alone produced urea, as well as albumin and transferrin (both measured by immunodiffusion), at constant rates during a 4.25-h perfusion.
Gene_expression (produced) of albumin in livers associated with halothane
6) Confidence 0.77 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.26
Baseline and postintervention changes in weight, absolute lymphocyte counts, and albumin levels in both groups were statistically compared.
Gene_expression (levels) of albumin in lymphocyte
7) Confidence 0.77 Published 2007 Journal Chest Section Body Doc Link 17890482 Disease Relevance 0.31 Pain Relevance 0
At 5 times therapeutic plasma concentrations, albumin synthesis was inhibited 40% (ibuprofen), 35% (flurbiprofen) and 100% (butibufen) after 6 h exposure and significant effects were also observed after 24 h exposure. 5.
Gene_expression (synthesis) of albumin in plasma
8) Confidence 0.76 Published 1988 Journal Xenobiotica Section Abstract Doc Link 3420949 Disease Relevance 0.15 Pain Relevance 0.07
Skin testing with aqueous albumin extracts of tolmetin and zomepirac was negative.
Gene_expression (extracts) of albumin in Skin
9) Confidence 0.76 Published 1983 Journal Ann Allergy Section Abstract Doc Link 6846923 Disease Relevance 0.09 Pain Relevance 0.47
Urinary albumin, expressed as a creatinine ratio (ACR), was measured before and 1 and 2 hours after standardised exercise following 1 week treatment with either active drug or placebo.
Gene_expression (expressed) of albumin
10) Confidence 0.75 Published 1994 Journal Eur J Vasc Surg Section Abstract Doc Link 8181617 Disease Relevance 0.81 Pain Relevance 0.07
After exposure for 24 and 48 h to acetaminophen (2.5 mM), gel entrapped hepatocytes were more severely damaged than hepatocyte monolayer detected by methyl thiazolyl tetrazolium (MTT) reduction, intracellular glutathione (GSH) content, reactive oxygen species (ROS) levels, urea genesis and albumin synthesis.
Gene_expression (synthesis) of albumin in hepatocytes associated with paracetamol
11) Confidence 0.75 Published 2006 Journal Chem. Biol. Interact. Section Abstract Doc Link 16797510 Disease Relevance 0.44 Pain Relevance 0.37
Measures of hepatocyte-specific function included albumin synthesis, ureagenesis, lidocaine biotransformation, and cholate conjugation.
Gene_expression (synthesis) of albumin in hepatocyte associated with lidocaine
12) Confidence 0.74 Published 1992 Journal Cytotechnology Section Abstract Doc Link 1369236 Disease Relevance 0 Pain Relevance 0.10
Albumin synthesis remained stable, while representative P-450 and conjugation activities decreased with time.
Gene_expression (synthesis) of Albumin
13) Confidence 0.74 Published 1992 Journal Cytotechnology Section Abstract Doc Link 1369236 Disease Relevance 0 Pain Relevance 0.09
Alterations in the spinal cord microenvironment in a neuropathic pain model in rats comprising right L-4 spinal nerve lesion were examined following 1, 2, 4 and 10 weeks using albumin and glial fibrillary acidic protein (GFAP) immunoreactivity.
Gene_expression (using) of albumin in spinal nerve associated with neuropathic pain and spinal cord
14) Confidence 0.67 Published 2006 Journal Pain Section Abstract Doc Link 16806707 Disease Relevance 0.10 Pain Relevance 0.26
However, halothane given twice to rats at 24-h intervals (group IV) reduced their mean albumin synthesis rate to half that of controls.
Gene_expression (synthesis) of albumin associated with halothane
15) Confidence 0.67 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.09 Pain Relevance 0.88
Urea production did not differ in the two treatment groups, but halothane depressed albumin and transferrin synthesis 43% and 45%, respectively.
Gene_expression (synthesis) of albumin associated with halothane
16) Confidence 0.67 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.51
The increase in cerebrovascular permeability was temporary, however, although Evans blue albumin extravasion remained slightly elevated 3 h after infusion, it was normal 6 h after infusion.
Gene_expression (extravasion) of albumin
17) Confidence 0.67 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7637893 Disease Relevance 0 Pain Relevance 0.08
Montelukast had no effect in the extrapulmonary airways but abolished albumin extravasation in the intrapulmonary airways of RSV-infected rats, with a larger effect in weanlings than in adults.
Gene_expression (extravasation) of albumin associated with respiratory syncytial virus
18) Confidence 0.67 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 11943681 Disease Relevance 0.79 Pain Relevance 0.32
The objectives of this study were to determine whether 1) the leukocyte-endothelial cell adhesion observed in venules exposed to nonsteroidal anti-inflammatory drugs (NSAIDs) is accompanied by enhanced albumin extravasation, and 2) leukocytes mediate this endothelial cell barrier dysfunction.
Gene_expression (extravasation) of albumin in venules associated with inflammation, cinod and adhesions
19) Confidence 0.67 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8779980 Disease Relevance 0.42 Pain Relevance 0.48
A significant inhibition of albumin extravasation was seen following lidocaine (P less than 0.001) or bupivacaine (P less than 0.001) treatment compared with treatment with isotonic saline.
Gene_expression (extravasation) of albumin associated with lidocaine
20) Confidence 0.67 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3195759 Disease Relevance 0.24 Pain Relevance 0.56

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