INT61300

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.00
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
spinal cord 4
plasma 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 291 100.00 Very High Very High Very High
bradykinin 81 100.00 Very High Very High Very High
antagonist 63 100.00 Very High Very High Very High
Dorsal horn 15 99.98 Very High Very High Very High
Spinal cord 87 99.44 Very High Very High Very High
Peripheral nerve injury 3 95.44 Very High Very High Very High
Neuropathic pain 18 94.04 High High
cytokine 27 92.28 High High
Thermal hyperalgesia 24 91.44 High High
Hyperalgesia 30 87.52 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 195 99.44 Very High Very High Very High
Nervous System Injury 12 95.44 Very High Very High Very High
Neuropathic Pain 192 94.04 High High
Hyperalgesia 63 91.44 High High
Sleep Disorders 1 87.48 High High
Heart Rate Under Development 1 87.08 High High
Pressure Volume 2 Under Development 1 86.56 High High
INFLAMMATION 41 85.96 High High
Inflammatory Pain 3 85.28 High High
Targeted Disruption 3 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoradiography studies showed a widespread distribution of kinin B1R binding sites in the spinal cord of diabetic rats [19,21-23].
Negative_regulation (distribution) of B1R Binding (binding) of in spinal cord associated with diabetes mellitus, b1 receptor and spinal cord
1) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.57 Pain Relevance 1.45
Fluorocitrate (1 nmol, i.t.) administered in STZ-diabetic rats, 3 h prior sacrifice, reduced (-38%) the increased density of specific B1R binding sites induced by diabetes to values (1.532 fmol/mg protein) not significantly different from control density (Figure 4).


Neg (not) Negative_regulation (reduced) of B1R Binding (binding) of associated with diabetes mellitus and b1 receptor
2) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.69 Pain Relevance 0.87
Pretreatment with bradykinin B2-receptor antagonist Hoe-140 (100 nmol/kg), but not the B1-receptor antagonist des-Arg9-Leu8-bradykinin (5 mg/kg), abolished plasma extravasation evoked by T-kinin (1 mumol/kg).
Negative_regulation (abolished) of B1-receptor Binding (Pretreatment) of in plasma associated with antagonist and bradykinin
3) Confidence 0.41 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 8567553 Disease Relevance 0.17 Pain Relevance 0.37
A 3 h treatment with fluorocitrate normalized B1R mRNA level, yet specific dorsal horn B1R binding sites were reduced by only 38% in the spinal cord of STZ rats.
Negative_regulation (reduced) of B1R Binding (binding) of in spinal cord associated with b1 receptor, dorsal horn and spinal cord
4) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.31 Pain Relevance 1.00
Pretreatment with kallikrein kinin inhibitor (aprotinin; 6000 kallikrein inactivating unit, i.v.) blocked the BT venom-induced augmentation of PDG reflex response.
Negative_regulation (blocked) of kallikrein kinin Binding (Pretreatment) of
5) Confidence 0.01 Published 1998 Journal Toxicon Section Abstract Doc Link 9620578 Disease Relevance 0.26 Pain Relevance 0

General Comments

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