INT61301

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 21
Disease Relevance 16.95
Pain Relevance 15.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
spinal cord 9
aorta 3
liver 3
spinal nerve 2
brain 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 1560 100.00 Very High Very High Very High
b2 receptor 1 100.00 Very High Very High Very High
Spinal cord 226 99.92 Very High Very High Very High
cytokine 33 99.56 Very High Very High Very High
Pain 115 99.52 Very High Very High Very High
Inflammation 80 99.36 Very High Very High Very High
allodynia 381 99.28 Very High Very High Very High
Peripheral nerve injury 4 98.84 Very High Very High Very High
Brush evoked pain 74 98.68 Very High Very High Very High
IPN 30 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 501 100.00 Very High Very High Very High
Pressure And Volume Under Development 285 99.96 Very High Very High Very High
Neuropathy 64 99.82 Very High Very High Very High
Congenital Anomalies 47 99.78 Very High Very High Very High
Targeted Disruption 56 99.68 Very High Very High Very High
Pain 100 99.52 Very High Very High Very High
INFLAMMATION 89 99.36 Very High Very High Very High
Neuropathic Pain 532 99.28 Very High Very High Very High
Hyperglycemia 31 99.28 Very High Very High Very High
Insulin Resistance 197 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we reported that all these abnormalities including B1R overexpression were reduced with a diet containing alpha-lipoic acid or N-Acetyl-L-Cysteine, two potent antioxidants [2], [3], supporting a link between the upregulation of B1R, diabetic complications and the oxidative stress.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R associated with stress, diabetes complications, congenital anomalies and b1 receptor
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.16 Pain Relevance 1.11
Recent evidence suggests a link between insulin resistance, oxidative stress, pain polyneuropathy and the overexpression of kinin B1 receptor [1], [2], [3].
Positive_regulation (overexpression) of Gene_expression (overexpression) of kinin B1 receptor associated with neuropathy, stress, pain, b1 receptor and insulin resistance
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.83 Pain Relevance 0.70
This overexpression of B1R binding sites in glucose-fed rats was significantly reduced in all laminae by the one-week treatment with 10 mg/kg SSR240612.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R associated with b1 receptor
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.06 Pain Relevance 0.62
Again, the overexpression of B1R mRNA in the spinal cord of glucose-fed rats was significantly and markedly decreased by SSR240612.


Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R mRNA in spinal cord associated with b1 receptor and spinal cord
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.05 Pain Relevance 0.78
The one-week treatment with 10 mg/kg SSR240612 reversed completely B1R mRNA overexpression in aorta and skeletal muscle and reduced significantly B1R mRNA level in the liver of glucose-fed rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R mRNA in liver associated with b1 receptor
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.08 Pain Relevance 0.78
Hence, the results highlight a key role for microglia and pro-inflammatory cytokines in the induction and overexpression of B1R in the spinal cord.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R in spinal cord associated with inflammation, b1 receptor, spinal cord and cytokine
6) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.22 Pain Relevance 1.31
This is consistent with the increased B1R mRNA and protein expression following a 12 h exposure of mesenteric vascular endothelial cells with 25 mM glucose [39].
Positive_regulation (increased) of Gene_expression (expression) of B1R mRNA in endothelial cells associated with b1 receptor
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.25 Pain Relevance 0.42
However in glucose-fed rats, B1R mRNA levels were markedly and significantly upregulated in the same tissues.
Positive_regulation (upregulated) of Gene_expression (levels) of B1R mRNA associated with b1 receptor
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.07 Pain Relevance 0.81
Relationship between oxidative stress, B1R and glucose-induced hypertension and allodynia
Positive_regulation (induced) of Gene_expression (stress) of B1R associated with stress, pressure and volume under development, allodynia and b1 receptor
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.27 Pain Relevance 0.92
We conclude that T-kinin produces airway vascular extravasation via stimulation of B2 receptors.
Positive_regulation (stimulation) of Gene_expression (produces) of T-kinin
10) Confidence 0.48 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 8567553 Disease Relevance 0.12 Pain Relevance 0.30
Membranes prepared from whole brain homogenates of heterozygous transgenic rats indicate a B1R expression level of 30 to 40 fmol/mg; there is no detectable B1R expression in control nontransgenic rats.
Neg (no) Positive_regulation (detectable) of Neg (no) Gene_expression (expression) of B1R in brain associated with targeted disruption
11) Confidence 0.47 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.78 Pain Relevance 0.30
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of Kinin B1 in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
12) Confidence 0.46 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
Part of the beneficial effects of SSR240612 appears to be associated with the normalization of B1R gene and protein expression which is dependent on the oxidative stress.



Positive_regulation (dependent) of Gene_expression (expression) of B1R associated with stress and b1 receptor
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.01 Pain Relevance 0.38
Also the experimental model of hypertension induced by chronic infusion of ANG II induced B1R expression in rat aorta [52] and spinal cord [53] as previously shown in cultured vascular smooth muscle [54] through a mechanism associated with the oxidative stress and NF-kB.
Positive_regulation (induced) of Gene_expression (expression) of B1R in aorta associated with stress, pressure and volume under development, b1 receptor and spinal cord
14) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.82 Pain Relevance 0.34
However, the expression of B1R is markedly enhanced in B2R knockout mice [72], [74].
Positive_regulation (enhanced) of Gene_expression (expression) of B1R associated with targeted disruption and b1 receptor
15) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.52 Pain Relevance 0.48
All these abnormalities including B1R overexpression (spinal cord, aorta, liver and gastrocnemius muscle) were normalized by the prolonged treatment with SSR240612.
Positive_regulation (overexpression) of Gene_expression (overexpression) of B1R in spinal cord associated with congenital anomalies, b1 receptor and spinal cord
16) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.08 Pain Relevance 0.70
The enhanced mRNA expression (B1R, IL-1?
Positive_regulation (enhanced) of Gene_expression (expression) of B1R associated with b1 receptor
17) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2913947 Disease Relevance 1.28 Pain Relevance 1.42
Western blot analysis revealed enhanced expression of kinin B(1) and B(2) receptor protein in ipsilateral L4-L6 spinal nerve and hind paw skin samples collected on Day 12 after SNL surgery.
Positive_regulation (enhanced) of Gene_expression (expression) of kinin B in spinal nerve associated with spinal nerve ligature
18) Confidence 0.45 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17555775 Disease Relevance 0.88 Pain Relevance 1.59
All these abnormalities including B1R overexpression (spinal cord, aorta, liver and gastrocnemius muscle) were normalized by the prolonged treatment with SSR240612.
Positive_regulation (overexpression) of in gastrocnemius Gene_expression (overexpression) of B1R in spinal cord associated with congenital anomalies, b1 receptor and spinal cord
19) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.08 Pain Relevance 0.70
All these abnormalities including B1R overexpression (spinal cord, aorta, liver and gastrocnemius muscle) were normalized by the prolonged treatment with SSR240612.
Positive_regulation (overexpression) of in liver Gene_expression (overexpression) of B1R in spinal cord associated with congenital anomalies, b1 receptor and spinal cord
20) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.08 Pain Relevance 0.70

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