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Context Info
Confidence 0.57
First Reported 1996
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
hippocampal formation 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 1 98.68 Very High Very High Very High
Hippocampus 2 90.52 High High
Serotonin 7 89.68 High High
tolerance 1 82.44 Quite High
Sumatriptan 1 71.64 Quite High
agonist 2 71.04 Quite High
Migraine 1 69.56 Quite High
fluoxetine 2 69.36 Quite High
Desipramine 2 64.64 Quite High
excitatory amino acid 1 31.12 Quite Low
Disease Link Frequency Relevance Heat
Frailty 7 99.80 Very High Very High Very High
Stress 9 98.44 Very High Very High Very High
Aging 2 82.48 Quite High
Syndrome 1 81.52 Quite High
Dementia 2 75.44 Quite High
Cognitive Disorder 2 75.00 Quite High
Headache 1 69.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated restraint stress in rats for 3 weeks causes changes in the hippocampal formation that include suppression of 5-HT1A receptor binding and atrophy of dendrites of CA3 pyramidal neurons, as well as impairment of initial learning of a radial arm maze task.
Negative_regulation (suppression) of 5-HT1A Binding (binding) of in hippocampal formation associated with stress, pyramidal cell and frailty
1) Confidence 0.57 Published 1997 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 9405958 Disease Relevance 1.29 Pain Relevance 0.43
Alkyl groups longer than eight carbon atoms impart reduced affinity for 5-HT1A receptors whereas groups longer than nine carbon atoms lead to compounds with reduced affinity at 5-HT1D beta receptors. 5-(Nonyloxy)tryptamine (10) represents a compound with optimal 5-HT1D beta affinity (Ki = 1 nM) and selectivity (> 300-fold).
Negative_regulation (reduced) of 5-HT1A Binding (affinity) of
2) Confidence 0.41 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8568822 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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