INT61315

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.29
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Coq10a) cellular_component (Coq10a) biological_process (Coq10a)
Anatomy Link Frequency
brain 2
F11 2
Coq10a (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 16 99.24 Very High Very High Very High
adenocard 7 99.24 Very High Very High Very High
opioid receptor 6 98.44 Very High Very High Very High
Central nervous system 6 97.60 Very High Very High Very High
dorsal root ganglion 8 97.00 Very High Very High Very High
narcan 8 94.72 High High
cerebral cortex 10 88.72 High High
action potential duration 2 82.24 Quite High
Dopamine 9 78.20 Quite High
MU agonist 2 58.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 10 97.60 Very High Very High Very High
Ganglion Cysts 8 97.00 Very High Very High Very High
Disease 163 96.60 Very High Very High Very High
Frailty 15 96.22 Very High Very High Very High
Weight Loss 9 95.86 Very High Very High Very High
Parkinson's Disease 39 94.92 High High
Neurodegenerative Disease 80 93.72 High High
Targeted Disruption 31 93.40 High High
Muscle Disease 6 92.72 High High
Encephalopathy 6 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induced CoQ10 deficiency in cells genetically altered to lack autophagy resulted in apoptosis, indicating that the autophagy was likely protective.25

Mitochondrial dysfunction and neurodegenerative disease: A rationale for testing CoQ10

Positive_regulation (Induced) of Gene_expression (deficiency) of CoQ10 associated with parkinson's disease, neurodegenerative disease and apoptosis
1) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.76 Pain Relevance 0
Consequences of CoQ10 deficiency
Positive_regulation (Consequences) of Gene_expression (deficiency) of CoQ10
2) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.00 Pain Relevance 0.09
This result suggests that GM1 itself could not sequester A?
Neg (not) Positive_regulation (sequester) of Neg (not) Gene_expression (sequester) of GM1
3) Confidence 0.41 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.07 Pain Relevance 0
In R6/2 and N171–82Q transgenic mouse models of HD, oral administration of coenzyme Q10 significantly prolonged survival and delayed motor deficits, weight loss, cerebral atrophy, and appearance of neuronal intranuclear inclusions.45 Brain levels of CoQ10 and CoQ9 were significantly lower in R6/2 mice relative to wild type mice, and oral supplementation with CoQ10 increased brain levels of CoQ9, CoQ10, and ATP, and reduced 8-hydroxy-2-deoxyguanosine levels.
Positive_regulation (increased) of Gene_expression (levels) of CoQ10 in brain associated with targeted disruption, weight loss, frailty and disease
4) Confidence 0.39 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.69 Pain Relevance 0.07
Furthermore, it was proposed that synthesis of GM1 is upregulated by prolonged activation of excitatory opioid receptor functions.
Positive_regulation (upregulated) of Gene_expression (synthesis) of GM1 associated with opioid receptor
5) Confidence 0.14 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568936 Disease Relevance 0.39 Pain Relevance 0.89
We show that chronic opioid exposure of F11 cells does, in fact, result in elevated levels of GM1 as well as cyclic adenosine monophosphate (AMP), concomitant with the onset of opioid excitatory supersensitivity as manifested by naloxone-evoked decreases in voltage-dependent membrane K+ currents.
Positive_regulation (result) of Gene_expression (levels) of GM1 in F11 associated with adenocard, narcan and opioid
6) Confidence 0.12 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568936 Disease Relevance 0.38 Pain Relevance 1.13

General Comments

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