INT61341

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.08
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
plasma 2
brain 2
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 80 99.98 Very High Very High Very High
depression 10 99.84 Very High Very High Very High
fluoxetine 4 99.64 Very High Very High Very High
antidepressant 14 99.08 Very High Very High Very High
long-term potentiation 45 97.28 Very High Very High Very High
rheumatoid arthritis 3 94.32 High High
Onset of action 1 93.88 High High
antinociception 5 93.84 High High
Pain 36 92.72 High High
monoamine 1 87.76 High High
Disease Link Frequency Relevance Heat
Pharyngitis 42 100.00 Very High Very High Very High
Depression 12 99.84 Very High Very High Very High
Schizophrenia 18 99.44 Very High Very High Very High
Psychosis 3 98.88 Very High Very High Very High
Obesity 169 98.68 Very High Very High Very High
Manic Depressive Disorder 9 98.00 Very High Very High Very High
Syndrome 4 96.72 Very High Very High Very High
Aging 124 94.32 High High
Rheumatoid Arthritis 3 94.32 High High
Pain 32 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results support the hypothesis that lower PEP activity could play a role in the pathophysiology of major depression, while increased PEP activity may be related to psychotic conditions, such as mania and schizophrenia.
Positive_regulation (increased) of PEP associated with manic depressive disorder, depression, psychosis and schizophrenia
1) Confidence 0.63 Published 1995 Journal Psychiatry Res Section Abstract Doc Link 8570777 Disease Relevance 1.07 Pain Relevance 0.31
In depressed subjects, plasma PEP activity was significantly increased during treatment with antidepressant drugs, such as fluoxetine.
Positive_regulation (increased) of PEP in plasma associated with antidepressant and fluoxetine
2) Confidence 0.55 Published 1995 Journal Psychiatry Res Section Abstract Doc Link 8570777 Disease Relevance 0.75 Pain Relevance 0.34
Compared with the 2% lidocaine and normal saline groups, the 10% lidocaine group had significantly increased severity of POST at 1, 6, and 12 hours after extubation.
Positive_regulation (increased) of POST
3) Confidence 0.49 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20304980 Disease Relevance 0 Pain Relevance 0
Plasma PEP activity was significantly increased in manic and schizophrenic subjects compared with normal volunteers.
Positive_regulation (increased) of PEP in Plasma associated with schizophrenia
4) Confidence 0.42 Published 1995 Journal Psychiatry Res Section Abstract Doc Link 8570777 Disease Relevance 0.75 Pain Relevance 0.34
s, methotrexate increased DPPIV (99–110%) and POP (60%), while cyclosporine inhibited POP (21%).
Positive_regulation (increased) of POP associated with methotrexate
5) Confidence 0.41 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0.07 Pain Relevance 0.32
disturbances were made when increased POP levels in synovial membrane
Positive_regulation (increased) of POP
6) Confidence 0.38 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.98 Pain Relevance 0.38
In summary, our data clearly show that utilizing POP in brain-targeting prodrug design to transport peptides into the brain could be especially useful when the therapeutic objective calls for a very quick onset of action, thus, release of the parent peptide.
Positive_regulation (utilizing) of POP in brain associated with onset of action
7) Confidence 0.10 Published 2008 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2709471 Disease Relevance 0.07 Pain Relevance 0.30
In addition, there were more female patients than male patients in our series, which might have increased the incidence of POST [16].
Positive_regulation (increased) of POST associated with pharyngitis
8) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 0.84 Pain Relevance 0.47
Secondary anti-His6 PE was added to the cells and incubated for 30 min on ice.
Positive_regulation (incubated) of PE
9) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
Expression
               and activation of the leptin receptor Ob-R and post-receptor signaling STAT-3,
                   O2? 
Positive_regulation (activation) of post-receptor
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.34 Pain Relevance 0
[5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine].
Positive_regulation (activation) of post-receptor in brain associated with antidepressant
11) Confidence 0.01 Published 2008 Journal Yao Xue Xue Bao Section Title Doc Link 18717332 Disease Relevance 0.07 Pain Relevance 0.57
The induction of LTP by a conventional high-frequency stimulation (HFS) protocol was significantly enhanced in the CA1 region of GluR2-cKO mice (60 minutes post-HFS, fEPSPs were potentiated to 255±19% of baseline in GluR2-cKO mice, n?
Positive_regulation (potentiated) of post-HFS associated with long-term potentiation
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.14 Pain Relevance 0.34

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