INT61359

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Context Info
Confidence 0.63
First Reported 1996
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 6.66
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)
Anatomy Link Frequency
endothelial cells 1
TNF (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 30 99.82 Very High Very High Very High
Inflammation 25 99.44 Very High Very High Very High
interstitial cystitis 9 97.92 Very High Very High Very High
cytokine 9 96.40 Very High Very High Very High
cINOD 9 95.68 Very High Very High Very High
agonist 4 94.08 High High
Paracetamol 1 92.00 High High
melanocortin 1 receptor 2 75.00 Quite High
Inflammatory stimuli 1 50.00 Quite Low
Inflammatory response 2 40.48 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Skin Cancer 29 99.84 Very High Very High Very High
INFLAMMATION 32 99.44 Very High Very High Very High
Adhesions 8 98.56 Very High Very High Very High
Interstitial Cystitis 9 97.92 Very High Very High Very High
Injury 6 96.72 Very High Very High Very High
Radiation Sickness 1 94.84 High High
Hepatotoxicity 1 93.32 High High
Metastasis 4 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment of human myeloid ML-1a cells with capsaicin blocked TNF-mediated activation of NF-kappa B in a dose- and time-dependent manner.
TNF Positive_regulation (activation) of NF-kappa B associated with qutenza
1) Confidence 0.63 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.63
RESULTS: Nuclear factor kappaB activation by tumor necrosis factor-alpha, LPS and dsRNA was unaltered when cultured cells were incubated in sodium pentosan polysulfate before treatment.
tumor necrosis factor-alpha Positive_regulation (activation) of kappaB
2) Confidence 0.53 Published 2002 Journal J. Urol. Section Body Doc Link 12050558 Disease Relevance 0 Pain Relevance 0
BMS-470539 dose-dependently inhibited TNF-alpha-induced activation of a NF-kappaB transcriptional reporter in human melanoma cells, which endogenously express MC-1R.
TNF-alpha Positive_regulation (activation) of NF-kappaB associated with skin cancer
3) Confidence 0.50 Published 2006 Journal J. Leukoc. Biol. Section Abstract Doc Link 16888084 Disease Relevance 0.42 Pain Relevance 0.40
In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.
TNF Spec (examined) Positive_regulation (induced) of NF-kappa B associated with qutenza
4) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.61
In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.
TNF Spec (examined) Positive_regulation (activation) of NF-kappa B associated with qutenza
5) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.61
Sodium salicylate inhibited TNF-alpha-stimulated NF-kappaB activation in melanoma cells in a concentration-dependent manner, and this was achieved with pre-incubation times as short as 15 min.
TNF-alpha Positive_regulation (activation) of NF-kappaB associated with skin cancer
6) Confidence 0.38 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.74 Pain Relevance 0.03
The activation of NF-kappaB by rhTNF-alpha was associated with 27, eight, ten and sevenfold increases in the TNF-alpha, IL-1beta, IL-6 and IL-8 transcripts, respectively.
rhTNF-alpha Positive_regulation (activation) of NF-kappaB
7) Confidence 0.36 Published 2003 Journal Urol. Res. Section Abstract Doc Link 14574533 Disease Relevance 0.70 Pain Relevance 0.63
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
TNF-alpha Positive_regulation (activation) of NF-kappaB associated with inflammation and adhesions
8) Confidence 0.35 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.69 Pain Relevance 0.05
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
TNF-alpha Positive_regulation (activation) of NF-kappaB associated with skin cancer
9) Confidence 0.35 Published 2006 Journal Melanoma Res. Section Title Doc Link 16432451 Disease Relevance 0.74 Pain Relevance 0.04
In conclusion, sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo.
TNF-alpha Positive_regulation (upregulation) of NF-kappaB associated with inflammation, cinod, skin cancer and metastasis
10) Confidence 0.35 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.90 Pain Relevance 0.14
Of the two catalytic subunits of IKK (IKKalpha and IKKbeta), low concentrations of NAC and mito-Q activated IKKalpha activity, thereby inhibiting the downstream NF-kappaB and ICAM-1 induction by TNF-alpha.
TNF-alpha Positive_regulation (induction) of NF-kappaB
11) Confidence 0.23 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21
High concentrations of NAC and mito-Q instead caused glutathionylation of IKKalpha, thereby inhibiting its activity that in turn enhanced the downstream NF-kappaB activation and ICAM-1 expression by TNF-alpha.
TNF-alpha Positive_regulation (activation) of NF-kappaB
12) Confidence 0.23 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21
The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).
TNF alpha Positive_regulation (activation) of kappa B associated with necrosis and cancer
13) Confidence 0.23 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.64 Pain Relevance 0.09
We have demonstrated that two structurally distinct yet highly selective proteasome inhibitors (MG341, lactacystin) inhibit tumor necrosis factor (TNF)-induced NFKB activation as well as ECAM expression in human endothelial cells in vitro.
TNF Positive_regulation (activation) of NFKB in endothelial cells associated with necrosis and cancer
14) Confidence 0.05 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.44 Pain Relevance 0.23

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