INT61360

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Context Info
Confidence 0.21
First Reported 1996
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)
TNF (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 100.00 Very High Very High Very High
Paracetamol 1 93.32 High High
Inflammatory stimuli 1 50.00 Quite Low
cINOD 1 25.00 Low Low
interstitial cystitis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Adhesions 1 98.56 Very High Very High Very High
Radiation Sickness 1 96.16 Very High Very High Very High
Skin Cancer 7 95.80 Very High Very High Very High
Hepatotoxicity 1 94.64 High High
Syndrome 1 87.24 High High
Immunodeficiency 1 86.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).
Spec (examined) Regulation (effect) of TNF alpha Positive_regulation (activation) of kappa B associated with necrosis and cancer
1) Confidence 0.21 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.65 Pain Relevance 0.09
RESULTS: Nuclear factor kappaB activation by tumor necrosis factor-alpha, LPS and dsRNA was unaltered when cultured cells were incubated in sodium pentosan polysulfate before treatment.
Regulation (unaltered) of tumor necrosis factor-alpha Positive_regulation (activation) of kappaB
2) Confidence 0.20 Published 2002 Journal J. Urol. Section Body Doc Link 12050558 Disease Relevance 0 Pain Relevance 0
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Spec (investigate) Regulation (effect) of TNF-alpha Positive_regulation (activation) of NF-kappaB associated with inflammation and adhesions
3) Confidence 0.20 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.70 Pain Relevance 0.05

General Comments

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