INT61363

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 26.43
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
chondrocytes 2
fat 2
B cells 2
Notch 1
cartilage 1
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 111 99.96 Very High Very High Very High
Inflammatory mediators 6 99.66 Very High Very High Very High
dexamethasone 63 99.40 Very High Very High Very High
Osteoarthritis 208 99.36 Very High Very High Very High
aspirin 86 98.88 Very High Very High Very High
COX2 7 98.58 Very High Very High Very High
Inflammation 987 98.20 Very High Very High Very High
Cannabinoid 8 98.16 Very High Very High Very High
Multiple sclerosis 196 97.80 Very High Very High Very High
Arthritis 61 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 262 100.00 Very High Very High Very High
Adenoma 81 99.88 Very High Very High Very High
Apoptosis 185 99.84 Very High Very High Very High
Atherosclerosis 21 99.60 Very High Very High Very High
INFLAMMATION 1097 99.46 Very High Very High Very High
Osteoarthritis 209 99.36 Very High Very High Very High
Endometroid Carcinoma 36 98.96 Very High Very High Very High
Stomach Cancer 5 98.84 Very High Very High Very High
Stress 147 98.00 Very High Very High Very High
Multiple Sclerosis 207 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Italian authors reported that 2-fold increase of the mtTFA content was found in the endometrioid adenocarcinoma samples compared to the proliferative control endometrial samples [8].
Positive_regulation (increase) of mtTFA associated with endometroid carcinoma
1) Confidence 0.69 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.71 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.
Positive_regulation (increase) of TFAM
2) Confidence 0.63 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (increase) of transcription factor
3) Confidence 0.55 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
-secretase has been shown to be responsible for the processing of a growing number of type I integral membrane proteins including APP, APP-like proteins, E-Cadherin, CD44, lipoprotein receptor related protein, Notch, interferon response element and activated transcription factor 6 [17].
Positive_regulation (activated) of transcription factor 6 in Notch
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.15 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (increase) of TFAM
5) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
Currently, we do not know whether the upregulation of mtTFA, mtTFB1, and mtTFB2 in our experiments represent a compensatory mechanism in response to oxidative stress-related reduction in energy metabolism such as defective electron transport chain, incomplete mitochondrion biogenesis or accelerated apoptosis.
Spec (whether) Positive_regulation (upregulation) of mtTFA associated with stress and apoptosis
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.43 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Positive_regulation (increased) of TFAM
7) Confidence 0.19 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.22 Pain Relevance 0
In our study, we observed that mtTFA, mtTFB1, mtTFB2 transcriptional level and protein mass were augmented in the presence of Fe/ASC with no marked difference for POLRMT.
Neg (no) Positive_regulation (augmented) of mtTFA
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.48 Pain Relevance 0
Human mitochondrial transcription requires bacteriophage-related RNA polymerase, POLRMT, mtDNA-binding protein, h-mtTFA/TFAM, and two transcription factors/rRNA methyltransferases, h-mtTFB1 and h-mtTFB2.
Positive_regulation (requires) of mtTFA
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.08 Pain Relevance 0
Accordingly, mtTFA was found upregulated in response to lipopolysaccharide-induced oxidative damage to mitochondria, presumably to enhance mtDNA levels and OXPHOS activity [65].
Positive_regulation (upregulated) of mtTFA
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.35 Pain Relevance 0
-induced activation of transcription factor RUNX-2 in human OA chondrocytes
Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis
11) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.37
Our transcription and microarray analysis showed that TCF2 was upregulated.
Positive_regulation (upregulated) of TCF2
12) Confidence 0.08 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.72 Pain Relevance 0.28
induced activation and DNA binding activity of the transcription factor RUNX2 in human OA chondrocytes.
Positive_regulation (activation) of transcription factor in chondrocytes associated with osteoarthritis
13) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.88 Pain Relevance 0.42
A crucial step in this signalling pathway is thought to be activation of transcription factor NF-kappaB.
Positive_regulation (activation) of transcription factor
14) Confidence 0.06 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12727794 Disease Relevance 0.80 Pain Relevance 0.14
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Positive_regulation (upregulated) of transcription factor 2 in B cells associated with multiple sclerosis
15) Confidence 0.05 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.26 Pain Relevance 0.13
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Positive_regulation (upregulated) of TCF2 in B cells associated with multiple sclerosis
16) Confidence 0.05 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.26 Pain Relevance 0.13
ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.
Positive_regulation (activation) of transcription factor in T-cells
17) Confidence 0.05 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.56 Pain Relevance 0.08
We previously reported that TGZ induces an early growth response transcription factor (EGR-1) by the ERK phosphorylation pathway rather than by the PPARgamma pathway (Baek, S.
Positive_regulation (induces) of transcription factor
18) Confidence 0.04 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.44 Pain Relevance 0.12
Our transcription factor analysis demonstrated a positive prognostic impact for p53 as an “activated” transcription factor.
Positive_regulation (activated) of transcription factor
19) Confidence 0.04 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.66 Pain Relevance 0.03
Celecoxib, an NSAID, upregulated ER chaperones (GRP78 and its cochaperones ERdj3 and ERdj4) but also C/EBP homologous transcription factor (CHOP), a transcription factor involved in apoptosis.
Positive_regulation (upregulated) of transcription factor associated with cinod and apoptosis
20) Confidence 0.04 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.80 Pain Relevance 0.55

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