INT61364

Context Info Confidence 0.12 First Reported 1996 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.68 Pain Relevance 0.56

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency T-cells 2 TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 57 99.68 Nicotine 96 89.64 Paracetamol 1 80.24 Inflammation 26 79.88 b2 receptor 29 70.08 cva 10 67.16 agonist 11 50.00 peripheral neuropathy 12 29.28 bradykinin 41 17.44 cytokine 8 16.00

Disease Link Frequency Relevance Heat Stress 20 97.96 Necrosis 4 92.96 Cancer 10 92.60 Apoptosis 21 92.32 Radiation Sickness 1 83.08 Hepatotoxicity 1 81.56 INFLAMMATION 26 79.88 Multiple Myeloma 46 79.12 Syndrome 1 74.16 Immunodeficiency 1 73.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Currently, we do not know whether the upregulation of mtTFA, mtTFB1, and mtTFB2 in our experiments represent a compensatory mechanism in response to oxidative stress-related reduction in energy metabolism such as defective electron transport chain, incomplete mitochondrion biogenesis or accelerated apoptosis.

Spec (whether) Negative_regulation (represent) of Spec (whether) Positive_regulation (upregulation) of mtTFA associated with stress and apoptosis

1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.44 Pain Relevance 0

ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.

Negative_regulation (inhibited) of Positive_regulation (activation) of transcription factor in T-cells

2) Confidence 0.05 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.57 Pain Relevance 0.08

It ultimately inhibits the activation of the transcription factor NF-kB by protecting its inhibitor (IkB) from degradation by the proteasome complex (Fig. 2).

Negative_regulation (inhibits) of Positive_regulation (activation) of transcription factor

3) Confidence 0.02 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.42 Pain Relevance 0.03

It is therefore tempting to assume that the presently seen effects of dexamethasone are related to inhibition of transcription factor activation downstream of the JNK pathway.

Negative_regulation (inhibition) of Positive_regulation (activation) of transcription factor associated with dexamethasone

4) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.45

General Comments

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