INT61364
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Currently, we do not know whether the upregulation of mtTFA, mtTFB1, and mtTFB2 in our experiments represent a compensatory mechanism in response to oxidative stress-related reduction in energy metabolism such as defective electron transport chain, incomplete mitochondrion biogenesis or accelerated apoptosis. | |||||||||||||||
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ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells. | |||||||||||||||
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It ultimately inhibits the activation of the transcription factor NF-kB by protecting its inhibitor (IkB) from degradation by the proteasome complex (Fig. 2). | |||||||||||||||
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It is therefore tempting to assume that the presently seen effects of dexamethasone are related to inhibition of transcription factor activation downstream of the JNK pathway. | |||||||||||||||
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