INT61364

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Context Info
Confidence 0.12
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.68
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
T-cells 2
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 57 99.68 Very High Very High Very High
Nicotine 96 89.64 High High
Paracetamol 1 80.24 Quite High
Inflammation 26 79.88 Quite High
b2 receptor 29 70.08 Quite High
cva 10 67.16 Quite High
agonist 11 50.00 Quite Low
peripheral neuropathy 12 29.28 Quite Low
bradykinin 41 17.44 Low Low
cytokine 8 16.00 Low Low
Disease Link Frequency Relevance Heat
Stress 20 97.96 Very High Very High Very High
Necrosis 4 92.96 High High
Cancer 10 92.60 High High
Apoptosis 21 92.32 High High
Radiation Sickness 1 83.08 Quite High
Hepatotoxicity 1 81.56 Quite High
INFLAMMATION 26 79.88 Quite High
Multiple Myeloma 46 79.12 Quite High
Syndrome 1 74.16 Quite High
Immunodeficiency 1 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, we do not know whether the upregulation of mtTFA, mtTFB1, and mtTFB2 in our experiments represent a compensatory mechanism in response to oxidative stress-related reduction in energy metabolism such as defective electron transport chain, incomplete mitochondrion biogenesis or accelerated apoptosis.
Spec (whether) Negative_regulation (represent) of Spec (whether) Positive_regulation (upregulation) of mtTFA associated with stress and apoptosis
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.44 Pain Relevance 0
ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.
Negative_regulation (inhibited) of Positive_regulation (activation) of transcription factor in T-cells
2) Confidence 0.05 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.57 Pain Relevance 0.08
It ultimately inhibits the activation of the transcription factor NF-kB by protecting its inhibitor (IkB) from degradation by the proteasome complex (Fig. 2).
Negative_regulation (inhibits) of Positive_regulation (activation) of transcription factor
3) Confidence 0.02 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.42 Pain Relevance 0.03
It is therefore tempting to assume that the presently seen effects of dexamethasone are related to inhibition of transcription factor activation downstream of the JNK pathway.
Negative_regulation (inhibition) of Positive_regulation (activation) of transcription factor associated with dexamethasone
4) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.45

General Comments

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