INT61366

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Context Info
Confidence 0.26
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 13.75
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NFASC) plasma membrane (NFASC)
Anatomy Link Frequency
epithelial cells 2
SK-OV-3 1
perineum 1
neural 1
OVCAR-3 1
NFASC (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 2 99.96 Very High Very High Very High
fluoxetine 14 99.84 Very High Very High Very High
dexamethasone 4 98.68 Very High Very High Very High
cytokine 49 98.36 Very High Very High Very High
Inflammation 98 97.76 Very High Very High Very High
Inflammatory stimuli 6 97.76 Very High Very High Very High
antidepressant 2 96.60 Very High Very High Very High
peptic ulcer disease 2 96.36 Very High Very High Very High
Pain 15 95.52 Very High Very High Very High
Arthritis 96 94.00 High High
Disease Link Frequency Relevance Heat
Skin Infection 84 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Rectal Cancer 2 99.84 Very High Very High Very High
Injury 10 99.48 Very High Very High Very High
Death 8 99.42 Very High Very High Very High
Atherosclerosis 2 99.24 Very High Very High Very High
Abscess 20 98.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 98.16 Very High Very High Very High
Stomach Cancer 2 98.12 Very High Very High Very High
Cancer 42 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase in defecation frequency (NF: 3.5 pre versus 5.6/week post treatment; SF 3.6 pre versus 4.9/week post treatment) was found in both groups, but was not significantly different between the two formulas (p = 0.36).
Positive_regulation (increase) of NF
1) Confidence 0.26 Published 2007 Journal Nutr J Section Abstract Doc Link PMC1852321 Disease Relevance 0.17 Pain Relevance 0.16
As this result suggests an effect at transcriptional level, we examined whether the drug interferes with the activation of nuclear factor (NF)-kappaB and STAT3 transcription factors and with SAPK signal transducing factor.
Spec (whether) Positive_regulation (activation) of NF
2) Confidence 0.23 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.38
The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).
Positive_regulation (activation) of NF associated with necrosis and cancer
3) Confidence 0.21 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.63 Pain Relevance 0.09
PMA and TNF alpha induced activation of (NF)-kappa B in human Jurkat T-cells was partially inhibited by ADT (0.1 mM) pretreatment.
Positive_regulation (activation) of NF in T-cells
4) Confidence 0.20 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.60 Pain Relevance 0.09
NF is usually caused not only by trauma to the skin, such as that induced by insect bites, scratches, and abrasion, but also by surgical wounds in the perineum and lower extremities[2].
Positive_regulation (caused) of NF in perineum associated with skin infection, injury and insect bites and stings
5) Confidence 0.16 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2762971 Disease Relevance 1.34 Pain Relevance 0.04
It is well known that perineal NF, termed as "Fournier's gangrene," is caused by rectal cancer or periproctal abscess[4], and there are several reports on NF due to colorectal cancer involving the abdominal wall[5,6].
Positive_regulation (caused) of NF associated with skin infection, colon cancer, rectal cancer, abscess and increased venous pressure under development
6) Confidence 0.16 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2762971 Disease Relevance 2.01 Pain Relevance 0
This expresses itself as proliferation of activated microglia in the substantia nigra, activation and translocation of transcription factors and neurotrophic factor (NF), kappa-beta and elevation of cytotoxic cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.
Positive_regulation (activation) of NF in microglia associated with necrosis, cancer, substantia nigra and cytokine
7) Confidence 0.12 Published 2000 Journal J. Neurol. Section Abstract Doc Link 10991672 Disease Relevance 1.11 Pain Relevance 0.53
The apoptotic effect of fluoxetine (FLX), an antidepressant, against human epithelial ovarian cancer cell lines OVCAR-3 and SK-OV-3 was investigated in relation to the mitochondria-mediated cell death process and nuclear factor (NF)-kappaB activation.
Positive_regulation (activation) of NF in SK-OV-3 associated with antidepressant, ovarian cancer, apoptosis, death and fluoxetine
8) Confidence 0.10 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.60 Pain Relevance 0.62
The second category consists of patients in whom NF is induced by a single pathogen, usually GAS, and these patients usually have no underlying diseases.
Positive_regulation (induced) of NF associated with skin infection and disease
9) Confidence 0.07 Published 2008 Journal Cases J Section Body Doc Link PMC2547098 Disease Relevance 1.25 Pain Relevance 0.03
AGE inhibits the activation of the oxidant-induced transcription factor, nuclear factor (NF)-kappa B, which has clinical significance in human immunodeficiency virus gene expression and atherogenesis.
Positive_regulation (activation) of NF associated with atherosclerosis and acquired immune deficiency syndrome or hiv infection
10) Confidence 0.05 Published 2001 Journal J. Nutr. Section Abstract Doc Link 11238807 Disease Relevance 1.06 Pain Relevance 0.03
Therefore, the beneficial role of NF-?
Positive_regulation (role) of NF
11) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 1.03 Pain Relevance 0.43
IKK is a key convergence site of many different stimuli that induce NF-?
Positive_regulation (induce) of NF
12) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.77 Pain Relevance 0.32
Of these drugs, glucocorticoids like dexamethasone and prednisolone (although non-specific) are considered the most powerful NF-?
Positive_regulation (powerful) of NF associated with dexamethasone
13) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 1.05 Pain Relevance 0.57
The apoptotic effect of fluoxetine (FLX), an antidepressant, against human epithelial ovarian cancer cell lines OVCAR-3 and SK-OV-3 was investigated in relation to the mitochondria-mediated cell death process and nuclear factor (NF)-kappaB activation.
Positive_regulation (activation) of NF in OVCAR-3 associated with antidepressant, ovarian cancer, apoptosis, death and fluoxetine
14) Confidence 0.03 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.60 Pain Relevance 0.62
We have previously shown that H. pylori-induced NF-(kappa)B activation and interleukin (IL)-8 secretion are mediated by Toll-like receptor (TLR) 2 in epithelial cells.
Positive_regulation (pylori-induced) of NF in epithelial cells
15) Confidence 0.02 Published 2005 Journal Helicobacter Section Abstract Doc Link 15904477 Disease Relevance 0.71 Pain Relevance 0.10
We have previously shown that H. pylori-induced NF-(kappa)B activation and interleukin (IL)-8 secretion are mediated by Toll-like receptor (TLR) 2 in epithelial cells.
Positive_regulation (activation) of NF in epithelial cells
16) Confidence 0.02 Published 2005 Journal Helicobacter Section Abstract Doc Link 15904477 Disease Relevance 0.71 Pain Relevance 0.10
These induced cells were found to be positive for neural markers such as Nestin, GFAP, NeuN, BT, Neurofilament (NF-70), and TH [Figures 9–11].


Positive_regulation (positive) of NF-70 in neural
17) Confidence 0.01 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.10 Pain Relevance 0

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