INT61378

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.84
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Bcar1) plasma membrane (Bcar1) cytoplasm (Bcar1)
Anatomy Link Frequency
blood 1
Bcar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 21 100.00 Very High Very High Very High
antagonist 10 99.64 Very High Very High Very High
monoamine 3 98.88 Very High Very High Very High
Pain 10 95.88 Very High Very High Very High
Analgesic 6 95.76 Very High Very High Very High
agonist 120 91.08 High High
Glutamate 36 88.80 High High
Glutamate receptor 12 82.24 Quite High
analgesia 2 81.68 Quite High
Action potential 18 80.24 Quite High
Disease Link Frequency Relevance Heat
Chromosome Aberrations 8 100.00 Very High Very High Very High
Stroke 42 97.08 Very High Very High Very High
Pain 10 95.88 Very High Very High Very High
Hypertension 16 95.76 Very High Very High Very High
Carotid Stenosis 12 94.00 High High
Pathologic Constriction 28 88.52 High High
Cv General 4 Under Development 12 75.44 Quite High
Galactorrhea 7 75.16 Quite High
Heart Rate Under Development 8 74.40 Quite High
Pressure Volume 2 Under Development 9 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N-(N-L-Threonyl-L-alpha-aspartyl)-L-tyrosine (CAS 115053-54-8, SPA-S-646) was originally derived from lysozyme.
Positive_regulation (derived) of CAS
1) Confidence 0.45 Published 1995 Journal Arzneimittelforschung Section Abstract Doc Link 8573226 Disease Relevance 0 Pain Relevance 0.33
The reduction of blood pressure induced by the calcium antagonists brought about an increase in plasma CAs levels.
Positive_regulation (increase) of CAs in blood associated with catecholamine and antagonist
2) Confidence 0.41 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9145206 Disease Relevance 0.43 Pain Relevance 0.45
This range of CaS has been previously been reported in in vitro preparations (Womack and Khodakhah, 2004; McKay et al., 2005; Achard and De Schutter, 2008), however this is the first time it has been shown how easily the CaS can be activated by kainate receptors (100% activation of CaS).
Positive_regulation (activated) of CaS
3) Confidence 0.37 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.09
This range of CaS has been previously been reported in in vitro preparations (Womack and Khodakhah, 2004; McKay et al., 2005; Achard and De Schutter, 2008), however this is the first time it has been shown how easily the CaS can be activated by kainate receptors (100% activation of CaS).
Positive_regulation (activation) of CaS
4) Confidence 0.37 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.09
It can be inferred from these experiments that the influx of Ca2+ through the kainate receptors (Brorson et al., 1992; Huang et al., 2004), causes a direct increase in the Calcium frequency, as demonstrated in the increase in CaS during the UV illumination in Figure 6.
Positive_regulation (increase) of CaS
5) Confidence 0.32 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.07
5% of the overall current typically obtained upon full glutamatergic activation, and therefore, by selectively stimulating only the kainate receptors, one can activate the CaS without overwhelming the cell.
Positive_regulation (activate) of CaS
6) Confidence 0.32 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.20
During cyan illumination, there is a cessation of firing, and during UV illumination, the cell fires CaS at a higher frequency (3.36?
Positive_regulation (fires) of CaS
7) Confidence 0.23 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.07
The increase in islet CAs content in animals previously treated with precursors of CAs synthesis [13] would suggest that these enzymes could be actively involved in CAs turnover in islet cells.
Positive_regulation (increase) of CAs associated with catecholamine
8) Confidence 0.22 Published 2003 Journal BMC Endocr Disord Section Body Doc Link PMC153518 Disease Relevance 0 Pain Relevance 0.48
M), did not significantly affect ATPA induced CaS (n?
Neg (not) Positive_regulation (induced) of CaS
9) Confidence 0.22 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.10
S9 increased the induction of CAs in a dose-dependent manner to 15% at 2500 microM, with a high frequency of chromatid exchanges.
Positive_regulation (induction) of CAs associated with chromosome aberrations
10) Confidence 0.21 Published 2006 Journal Mutagenesis Section Abstract Doc Link 16595588 Disease Relevance 0.38 Pain Relevance 0.08
Eugenol induced CAs, with significant increases (3.5% aberrant cells) at 2500 microM, demonstrating cytotoxicity at higher doses.
Positive_regulation (induced) of CAs associated with chromosome aberrations
11) Confidence 0.21 Published 2006 Journal Mutagenesis Section Abstract Doc Link 16595588 Disease Relevance 0.38 Pain Relevance 0.09
Data for all patients who underwent CAS from January 2003 through November 2007, was retrieved from the Nanjing Stroke Registry.
Positive_regulation (underwent) of CAS associated with stroke
12) Confidence 0.07 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2981756 Disease Relevance 0.43 Pain Relevance 0
A total of 75 patients had undergone CAS since 2003.
Positive_regulation (undergone) of CAS
13) Confidence 0.07 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2981756 Disease Relevance 0.81 Pain Relevance 0
It is possible that A. castus may block estrogen receptors by binding to these receptors and exert anti-estrogen activity.
Positive_regulation (exert) of anti-estrogen
14) Confidence 0.03 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529385 Disease Relevance 0.41 Pain Relevance 0.40

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