INT61395

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Context Info
Confidence 0.30
First Reported 1995
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.83
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
brain 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 8 100.00 Very High Very High Very High
Lasting pain 1 99.36 Very High Very High Very High
nMDA receptor 30 95.60 Very High Very High Very High
Hippocampus 27 92.84 High High
Central nervous system 6 92.64 High High
headache 2 90.00 High High
isoflurane 6 88.36 High High
Pain 1 79.36 Quite High
Angina 1 78.56 Quite High
gABA 28 75.12 Quite High
Disease Link Frequency Relevance Heat
Depression 8 100.00 Very High Very High Very High
Stress 82 99.08 Very High Very High Very High
Pain 2 98.92 Very High Very High Very High
Convulsion 4 97.84 Very High Very High Very High
Hyperoxia 1 97.16 Very High Very High Very High
Toxicity 4 91.24 High High
Headache Disorders 1 90.64 High High
Cv General 3 Under Development 1 78.56 Quite High
Cv Unclassified Under Development 2 75.00 Quite High
Headache 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, activation of NOS by TDS stress is selectively blocked by the selective iNOS inhibitor, aminoguanidine and not the selective nNOS inhibitor, 7-nitroindazole (Harvey et al 2004).
Negative_regulation (inhibitor) of Neg (not) Negative_regulation (inhibitor) of nNOS associated with stress
1) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.94 Pain Relevance 0.29
Inhibition of nitric oxide synthase (with NG-nitro-L-arginine methyl ester [L-NAME]; 5 mg kg(-1), s.c.) augmented the ST segment depression in the ovariectomized rat and abolished the anti-ischaemic effect of 17beta-oestradiol or raloxifene.
Negative_regulation (abolished) of Negative_regulation (Inhibition) of nitric oxide synthase associated with depression
2) Confidence 0.24 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15249168 Disease Relevance 0.34 Pain Relevance 0.21
One potential mechanism for this protection is that NOS inhibition decreases cerebral O2 delivery thereby limiting the PO2 of brain tissues during hyperoxia.
Negative_regulation (decreases) of Negative_regulation (inhibition) of NOS in brain associated with hyperoxia
3) Confidence 0.16 Published 1995 Journal Undersea Hyperb Med Section Abstract Doc Link 8574125 Disease Relevance 0.29 Pain Relevance 0.09
BACKGROUND: Studies in animals have shown that nitric oxide plays an important part in central sensitisation and that inhibitors of nitric oxide synthase (NOS) decrease sensitisation in models of persistent pain.
Negative_regulation (decrease) of Negative_regulation (inhibitors) of nitric oxide synthase associated with pain and lasting pain
4) Confidence 0.10 Published 1999 Journal Lancet Section Abstract Doc Link 9929022 Disease Relevance 0.26 Pain Relevance 0.34
The current findings, along with the previous observations that structurally distinct NOS inhibitors and the nonspecific soluble guanylyl cyclase inhibitor methylene blue decrease the MAC for volatile anesthetics, support that this is an effect specific to the NOS-guanylyl cyclase signaling pathway.
Negative_regulation (decrease) of Negative_regulation (inhibitors) of NOS
5) Confidence 0.05 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15333406 Disease Relevance 0 Pain Relevance 0.32

General Comments

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