INT61399

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Context Info
Confidence 0.22
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 10.17
Pain Relevance 8.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
T-cell 2
dendritic cell 1
astrocytes 1
heart 1
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 387 100.00 Very High Very High Very High
cytokine 337 100.00 Very High Very High Very High
Opioid 28 99.82 Very High Very High Very High
rheumatoid arthritis 21 99.58 Very High Very High Very High
methotrexate 100 99.50 Very High Very High Very High
Morphine 82 98.72 Very High Very High Very High
MU agonist 4 97.16 Very High Very High Very High
adenocard 145 96.84 Very High Very High Very High
Potency 8 94.72 High High
Dynorphin 4 90.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 403 100.00 Very High Very High Very High
Asthma 104 99.84 Very High Very High Very High
Rheumatoid Arthritis 21 99.58 Very High Very High Very High
Inflammatory Bowel Disease 25 99.32 Very High Very High Very High
Obesity 123 99.20 Very High Very High Very High
Myocardial Infarction 28 99.08 Very High Very High Very High
Bordatella Infection 4 99.08 Very High Very High Very High
Targeted Disruption 115 98.92 Very High Very High Very High
Disease 122 98.76 Very High Very High Very High
Hypersensitivity 26 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low concentrations then elicited only a sustained increase in IK.
Positive_regulation (increase) of IK
1) Confidence 0.22 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.34 Pain Relevance 0.89
In contrast, microM concentrations rapidly elicited a sustained increase in IK.
Positive_regulation (increase) of IK
2) Confidence 0.22 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.34 Pain Relevance 0.79
Low concentrations (< nM) usually elicited a transient increase in IK (within 1 min), followed by a sustained decrease in IK.
Positive_regulation (increase) of IK
3) Confidence 0.22 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.32 Pain Relevance 0.76
On the other hand, after chronic treatment with pertussis toxin (PTX), the usual microM opioid-induced increases in IK no longer occurred and more than half of the cells responded with a sustained decrease of IK to microM as well as nM opioids.
Positive_regulation (increases) of IK associated with bordatella infection and opioid
4) Confidence 0.22 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.34 Pain Relevance 0.93
DCEBIO, a dichlorinated analogue of 1-EBIO, enhances the activity of IK channels with a ?
Positive_regulation (enhances) of IK
5) Confidence 0.15 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.12
IDelayed is a composite current, consisting of residual IA, non-inactivating IK,v, and IK(Ca) (Alkon et al., 1984; Farley, 1988; Farley and Wu, 1989; Jin et al., 2009).
Positive_regulation (inactivating) of IK
6) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
IDelayed is a composite current, consisting of residual IA, non-inactivating IK,v, and IK(Ca) (Alkon et al., 1984; Farley, 1988; Farley and Wu, 1989; Jin et al., 2009).
Positive_regulation (inactivating) of IK
7) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
Behavioral EU training significantly increases both IA and IDelayed (Farley et al., 1999) and enhancement of IDelayed is largely due to enhancement of IK(Ca).
Positive_regulation (enhancement) of IK
8) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
Moreover, methotrexate treatment augmented the accumulation of IL-10, a known anti-inflammatory cytokine, in wild-type mice and A3 knockout mice, but actually decreased IL-10 levels in A2A knockout mice.
Positive_regulation (accumulation) of cytokine associated with targeted disruption, inflammation, methotrexate and cytokine
9) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.21 Pain Relevance 1.15
Since adenosine receptor activation modulates the release of IL-10 by different inflammatory cells [25-27] and methotrexate-treated rheumatoid arthritis patients have shown increased serum levels of this cytokine [28,29], we determined whether constitutively or methotrexate-modified IL-10 accumulation in the inflammatory exudate was altered in adenosine receptor-deficient mice.
Positive_regulation (increased) of cytokine associated with adenocard, inflammation, rheumatoid arthritis, methotrexate and cytokine
10) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.15 Pain Relevance 0.77
This sequence of molecular events is associated with a marked induction of SOCS1, SOCS2, SOCS3, as well as cytokine-induced Src homology 2-containing protein expression.
Positive_regulation (induction) of cytokine associated with cytokine
11) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.14 Pain Relevance 0.09
The response of the CD4+ subset is more marked in terms, particularly, of 5-fold increase in GM-CSF, compared with a 2-fold increase in this cytokine by CD8+ T cells.
Positive_regulation (increase) of cytokine in T cells associated with cytokine
12) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.16 Pain Relevance 0.12
However, we do currently not know whether the increased cytokine signalling network in HF patients starts in the heart or in the periphery [12].
Spec (whether) Positive_regulation (increased) of cytokine in heart associated with myocardial infarction and cytokine
13) Confidence 0.01 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.84 Pain Relevance 0.51
Nevertheless, the role of IL-9 as an important TH2 type cytokine in bronchial asthma and other diseases (e.g., allergic, autoimmune) cannot be questioned.

3.

Positive_regulation (important) of cytokine associated with asthma, hypersensitivity, disease and cytokine
14) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.15 Pain Relevance 0.22
There were also major differences in the cytokine profile induced.
Positive_regulation (induced) of cytokine associated with cytokine
15) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.31 Pain Relevance 0.28
In addition to increases in cytokine levels cellular markers for T-cell activation, CD69, CD38, and CCR7 have been shown to be increased in dengue infection[33] and IFN?
Positive_regulation (increases) of cytokine in T-cell associated with dengue, infection and cytokine
16) Confidence 0.01 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 1.35 Pain Relevance 0.29
B nuclear translocation and cytokine gene upregulation in astrocytes treated with Tat±morphine.
Positive_regulation (upregulation) of cytokine in astrocytes associated with morphine and cytokine
17) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.74
Consistent with a stronger and more persistent expression driven by the pCAG promoter, high levels of Neurog2 and DsRed protein were still detected at 5–6 wk following retroviral transduction of cortical astroglia (unpublished data).
Positive_regulation (levels) of DsRed protein
18) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.27 Pain Relevance 0.08
In these studies, the nature of the specific P2 receptor subtype(s) responsible for the dendritic cell cytokine response was not addressed.While the above studies suggested that nucleotides may directly regulate cytokine output, more recent studies conducted with dendritic cells have focused on the role of extracellular nucleotides as modulators of cytokine output induced by other stimuli.
Positive_regulation (induced) of cytokine in dendritic cell associated with cytokine
19) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.33 Pain Relevance 0.49
This paracrine stimulation in turn elevates systemic cytokine levels observed in obese individuals.
Positive_regulation (elevates) of cytokine associated with obesity and cytokine
20) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 1.27 Pain Relevance 0.35

General Comments

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