INT614

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Context Info
Confidence 0.76
First Reported 1976
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 25.53
Pain Relevance 20.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
macrophage 8
leucocytes 4
plasma 1
liver 1
microglia 1
Cxcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 306 100.00 Very High Very High Very High
chemokine 236 100.00 Very High Very High Very High
Opioid 44 100.00 Very High Very High Very High
Sciatic nerve 16 99.84 Very High Very High Very High
cytokine 134 99.76 Very High Very High Very High
cva 236 99.74 Very High Very High Very High
acular 6 98.86 Very High Very High Very High
Neuritis 42 98.04 Very High Very High Very High
Peripheral nervous system 14 97.84 Very High Very High Very High
Acute pain 3 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 333 100.00 Very High Very High Very High
Subarachnoid Hemorrhage 140 99.74 Very High Very High Very High
Status Epilepticus 530 99.72 Very High Very High Very High
Injury 54 98.96 Very High Very High Very High
Pulmonary Embolism 90 98.88 Very High Very High Very High
Experimental Autoimmune Neuritis 42 98.04 Very High Very High Very High
Cancer 12 97.72 Very High Very High Very High
Necrosis 12 97.48 Very High Very High Very High
Demyelinating Disease 18 97.40 Very High Very High Very High
Pain 16 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MIP-2 and KC, but not CINC-2 were detectable in inflamed but not in noninflamed tissue (P<0.05, ANOVA).
Neg (not) Gene_expression (detectable) of MIP-2 associated with chemokine
1) Confidence 0.76 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.28 Pain Relevance 1.77
During exposure to volatile anesthetics, gene expression for IL-1beta, MIP-2, IFN-gamma, and TNF-alpha all increased significantly compared with mechanical ventilation alone.
Gene_expression (expression) of MIP-2
2) Confidence 0.72 Published 1999 Journal Anesthesiology Section Body Doc Link 10422944 Disease Relevance 0 Pain Relevance 0
Gene expression of MIP-2 and TNF-alpha was greater during mechanical than spontaneous ventilation and nonventilation control However, the concentrations of cytokines except MIP-2 and TNF-alpha were less than detection levels.
Gene_expression (expression) of MIP-2
3) Confidence 0.72 Published 1999 Journal Anesthesiology Section Body Doc Link 10422944 Disease Relevance 0 Pain Relevance 0
Using flow cytometry, immunohistochemistry, and ELISA, leukocyte subpopulations, chemokine receptor (CXCR2) expression on opioid-containing leukocytes and the CXCR2 ligands keratinocyte-derived chemokine (KC), macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) were quantified.
Gene_expression (expression) of MIP-2 in macrophage associated with chemokine, inflammation, opioid and cytokine
4) Confidence 0.66 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.48 Pain Relevance 1.59
Chemokines were blocked by intraplantar injection of anti-MIP-2 and/or anti-KC antiserum.
Gene_expression (injection) of anti-MIP-2 associated with chemokine
5) Confidence 0.58 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.40 Pain Relevance 1.79
However, MCP-1 inhibition persisted until 24 h. rmIL-1beta-induced MIP-2 and tumor necrosis factor-alpha mRNA expression were decreased by 36 and 24%, respectively, after halothane exposure.
Gene_expression (expression) of MIP-2
6) Confidence 0.56 Published 2003 Journal Anesthesiology Section Body Doc Link 12502982 Disease Relevance 0 Pain Relevance 0
Dynamics of production of MIP-1alpha, MCP-1 and MIP-2 and potential role of neutralization of these chemokines in the regulation of immune responses during experimental autoimmune neuritis in Lewis rats.
Gene_expression (production) of MIP-2 associated with chemokine, experimental autoimmune neuritis and neuritis
7) Confidence 0.54 Published 1999 Journal J. Neuroimmunol. Section Title Doc Link 10430050 Disease Relevance 1.27 Pain Relevance 1.05
MIP-2 and KC, but not CINC-2 were detectable in inflamed but not in noninflamed tissue (P<0.05, ANOVA).
Neg (not) Gene_expression (detectable) of CINC-2 associated with chemokine
8) Confidence 0.51 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.27 Pain Relevance 1.71
Furthermore, the direct involvement of polyamines in stimulation of the synthesis of vasoregulin, a known anti inflammatory protein by its direct action on leukocytes had been reported.[22] This inherent effect of polyamines cannot be ignored for the observed anti-inflammatory activity of polyamines.
Gene_expression (synthesis) of inflammatory protein in leukocytes associated with inflammation
9) Confidence 0.49 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792602 Disease Relevance 0.95 Pain Relevance 0.41
In the present study, the dynamics of the expression of the chemokines macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-2 and monocyte chemotactic protein-1 (MCP-1) were determined in the sciatic nerves of EAN rats.
Gene_expression (expression) of MIP-2 in macrophage associated with chemokine, inflammation, sciatic nerve and neuritis
10) Confidence 0.47 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10430050 Disease Relevance 1.34 Pain Relevance 1.10
MIP-2 is a chemokine predominantly produced by mononuclear leucocytes which attracts PMNs and IL-10 is a well known anti-inflammatory cytokine.
Gene_expression (produced) of MIP-2 in leucocytes associated with chemokine, inflammation and cytokine
11) Confidence 0.46 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2386131 Disease Relevance 0.38 Pain Relevance 0.44
The expression of interleukin (IL)-1alpha, IL-1beta, IL-6, macrophage inflammatory protein-2, interferon-gamma, and tumor necrosis factor-alpha was measured by semiquantitative reverse-transcription polymerase chain reaction.
Gene_expression (expression) of macrophage inflammatory protein-2 in macrophage
12) Confidence 0.44 Published 1999 Journal Anesthesiology Section Body Doc Link 10598627 Disease Relevance 0 Pain Relevance 0
Polyamines have been postulated to have anti-inflammatory and anti-oxidant properties.[1] It has been suggested that they exert at least two different anti-inflammatory mechanisms, the first one is mediated by the synthesis of an anti-inflammatory protein (vasoregulin)[5] and the second one is their direct action on leucocytes.[6] Most of the reported studies however have been conducted on several cell-lines in vitro and those in vivo have been of a preliminary nature.
Gene_expression (synthesis) of inflammatory protein in leucocytes associated with inflammation
13) Confidence 0.44 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792602 Disease Relevance 0.55 Pain Relevance 0.25
MCP-1 and MIP-2 expression after SE
Gene_expression (expression) of MIP-2 associated with status epilepticus
14) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.08 Pain Relevance 0.03
Neurons, microglia and astrocytes produce MCP-1 or MIP-2 when incubated with pro-inflammatory cytokines, such as tumor necrosis factor-?
Gene_expression (produce) of MIP-2 in astrocytes associated with necrosis, inflammation, cancer and cytokine
15) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.34 Pain Relevance 0.59
These findings indicate that P2X7 receptor activation may accelerate up-regulation of MCP-1 and MIP-2 expression in the FPC, resulting in leukocyte infiltration.


Gene_expression (expression) of MIP-2 in leukocyte
16) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.98 Pain Relevance 0.05
As shown in Fig. 5, CXCL 1 gene expression was higher in groups containing 25 µg PDGF encapsulated in high and low MW PLGA microspheres than in other groups, while higher CXCL2 gene expression was found only in the group containing 25 µg PDGF encapsulated in high MW PLGA microspheres, compared to all other groups.
Gene_expression (expression) of CXCL2 gene
17) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.11
, and MIP-2 were not detected in the plasma.
Neg (not) Gene_expression (detected) of MIP-2 in plasma
18) Confidence 0.36 Published 2000 Journal Crit Care Section Body Doc Link PMC29035 Disease Relevance 0.18 Pain Relevance 0.08
Results from cDNA array showed that PDGF strongly enhanced in vivo gene expression of the CXC chemokine family members such as CXCL1, CXCL2 and CXCL5.
Gene_expression (expression) of CXCL2 associated with chemokine
19) Confidence 0.33 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.08 Pain Relevance 0.13
To establish whether the attraction of neutrophils is correlated with the expression of chemokines, we next questioned whether SAH induced the expression of pulmonary macrophage inflammatory protein (MIP)-1?
Gene_expression (expression) of macrophage inflammatory protein in neutrophils associated with chemokine, inflammation and cva
20) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2945141 Disease Relevance 1.39 Pain Relevance 0.76

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