INT61400

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Context Info
Confidence 0.22
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.56
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 85 100.00 Very High Very High Very High
cytokine 10 100.00 Very High Very High Very High
methotrexate 50 99.78 Very High Very High Very High
Opioid 5 91.80 High High
MU agonist 1 91.04 High High
Dynorphin 1 85.84 High High
agonist 8 85.40 High High
Kappa opioid receptor 3 85.08 High High
adenocard 72 83.32 Quite High
opioid receptor 2 81.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 85 100.00 Very High Very High Very High
Targeted Disruption 46 98.92 Very High Very High Very High
Vibrio Infection 1 97.68 Very High Very High Very High
Neuroblastoma 2 89.52 High High
Bordatella Infection 1 79.04 Quite High
Experimental Arthritis 2 68.48 Quite High
Rheumatoid Arthritis 4 52.28 Quite High
Disease 4 14.72 Low Low
Necrosis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, microM concentrations rapidly elicited a sustained increase in IK.
Positive_regulation (elicited) of Positive_regulation (increase) of IK
1) Confidence 0.22 Published 1995 Journal Brain Res. Section Abstract Doc Link 8574691 Disease Relevance 0.34 Pain Relevance 0.80
Moreover, methotrexate treatment augmented the accumulation of IL-10, a known anti-inflammatory cytokine, in wild-type mice and A3 knockout mice, but actually decreased IL-10 levels in A2A knockout mice.
Positive_regulation (augmented) of Positive_regulation (accumulation) of cytokine associated with targeted disruption, inflammation, methotrexate and cytokine
2) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.22 Pain Relevance 1.15

General Comments

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