INT61416

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Context Info
Confidence 0.11
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.85
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
cervix 3
myometrium 1
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 70.08 Quite High
Clonidine 1 65.92 Quite High
cytokine 10 65.68 Quite High
noradrenaline 1 64.96 Quite High
Inflammation 16 7.32 Low Low
Angina 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 98.34 Very High Very High Very High
Coronary Artery Disease 55 95.28 Very High Very High Very High
Thrombosis 1 75.48 Quite High
Atherosclerosis 2 70.96 Quite High
Apoptosis 6 68.44 Quite High
Stress 5 60.28 Quite High
Injury 5 56.16 Quite High
Hypoxia 2 49.36 Quite Low
Eclampsia 2 43.28 Quite Low
INFLAMMATION 18 7.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of Positive_regulation (increased) of CD11a in cervix associated with adhesions
1) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
The baculovirus expression vector system utilizing the strong polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus (AcNPV) was used for high level expression of the two alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 in Spodoptera frugiperda (Sf-9) insect cells.
Positive_regulation (used) of Positive_regulation (utilizing) of polyhedrin gene promoter
2) Confidence 0.07 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.16
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of in myometrium Positive_regulation (increased) of CD11a in cervix associated with adhesions
3) Confidence 0.04 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Consistent with the computation, our study confirmed that C allele of SNP rs2236659 leads to an increase in promoter activity and probably heightens synthesis level of the corresponding HSPA8 protein which could decreases the risk of CHD.
Positive_regulation (leads) of Positive_regulation (increase) of promoter associated with coronary artery disease
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.65 Pain Relevance 0

General Comments

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