INT61417

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 36
Total Number 40
Disease Relevance 29.62
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
leukocyte 5
neutrophils 4
osteoclast 3
blood 2
lymphocyte 2
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 42 100.00 Very High Very High Very High
Enkephalin 12 99.92 Very High Very High Very High
Opioid 14 99.74 Very High Very High Very High
Inflammation 319 98.20 Very High Very High Very High
Migraine 8 97.56 Very High Very High Very High
Angina 5 97.48 Very High Very High Very High
chemokine 68 96.80 Very High Very High Very High
cytokine 206 95.76 Very High Very High Very High
endometriosis 168 95.36 Very High Very High Very High
Multiple sclerosis 12 93.28 High High
Disease Link Frequency Relevance Heat
Adhesions 379 100.00 Very High Very High Very High
Disease 298 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 284 99.84 Very High Very High Very High
Cancer 140 99.16 Very High Very High Very High
Epilepsy 8 98.44 Very High Very High Very High
INFLAMMATION 361 98.20 Very High Very High Very High
Pressure And Volume Under Development 97 98.00 Very High Very High Very High
Necrosis 28 97.76 Very High Very High Very High
Headache 11 97.56 Very High Very High Very High
Cv General 3 Under Development 5 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measures included sensory and affective pain responses, perceived stress, circulating levels of catecholamines, cortisol, and expression of integrin (CD11a+) cellular adhesion molecules on leukocyte subsets.
Gene_expression (expression) of CD11a in leukocyte
1) Confidence 0.75 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 18073496 Disease Relevance 0.09 Pain Relevance 0
Many of these cells also express LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), and VLA-4 (CD49d/CD29) on their surfaces.
Gene_expression (express) of CD11a
2) Confidence 0.75 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.81 Pain Relevance 0.12
In bone, ICAM-1 is expressed at the surface of osteoblasts (Obs) and its counter-receptor, leukocyte function-associated antigen-1 (LFA-1; CD11a), at the surface of osteoclast (Oc) precursors.
Gene_expression (expressed) of CD11a in osteoclast
3) Confidence 0.65 Published 2005 Journal Expert Opin Biol Ther Section Abstract Doc Link 15833069 Disease Relevance 1.25 Pain Relevance 0.32
Anti-CD11a antibody: Efalizumab: LFA-1, a heterodimer of CD11a and CD18, is a member of the ?
Gene_expression (antibody) of CD11a
4) Confidence 0.65 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.56 Pain Relevance 0.16
Leukocyte function-associated antigen 1 and intercellular adhesion molecule 1 are co-stimulatory molecules expressed on T cells and antigen-presenting cells, respectively, which facilitate multiple T-cell-mediated events.
Gene_expression (expressed) of Leukocyte function-associated antigen 1 in T-cell associated with adhesions
5) Confidence 0.61 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727906 Disease Relevance 0.88 Pain Relevance 0.16
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Gene_expression (expression) of CD11a in neutrophil
6) Confidence 0.60 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Gene_expression (expression) of CD11a in blood associated with opioid
7) Confidence 0.55 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.92
We have also tested the effect of beta-endorphin and met-enkephalin on CD11a, CD11b, CD18 and CD16 molecule expression on PMN in vitro.
Gene_expression (expression) of CD11a associated with enkephalin
8) Confidence 0.55 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.17 Pain Relevance 0.78
The interpretation of allergic/atopic predisposition in POEE risk was indicated by our recent observation of elevated leukocyte function asscoiated molecule-1 (LFA-1) expression on leukocytes of at risk patients [18], as LFA-1 expression is increased on leukocytes of atopic children [36].
Gene_expression (expression) of LFA-1 in leukocytes associated with pressure and volume under development and hypersensitivity
9) Confidence 0.26 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.13 Pain Relevance 0.03
The interpretation of allergic/atopic predisposition in POEE risk was indicated by our recent observation of elevated leukocyte function asscoiated molecule-1 (LFA-1) expression on leukocytes of at risk patients [18], as LFA-1 expression is increased on leukocytes of atopic children [36].
Gene_expression (expression) of LFA-1 in leukocytes associated with pressure and volume under development and hypersensitivity
10) Confidence 0.26 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.17 Pain Relevance 0.05
Neutrophils from labouring women showed a significantly higher surface expression of CD11a and CD11b (P = 0.001) and CD62L (P < 0.02) compared with the non-labouring women.
Gene_expression (expression) of CD11a in Neutrophils
11) Confidence 0.17 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0
Over 90% of neutrophils expressed each of the cell surface markers CD11a, CD 11b and CD62L, and there were no significant differences in the numbers of expressing cells between labouring and non-labouring women (data not shown).
Gene_expression (expressed) of CD11a in neutrophils
12) Confidence 0.17 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.08 Pain Relevance 0
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Gene_expression (expression) of CD11a in cervix associated with adhesions
13) Confidence 0.17 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
In fact, as we recently demonstrated [20], CD133+ stem cells express several adhesion molecules, such as CD44, LFA-1, PSGL-1, ?
Gene_expression (express) of LFA-1 in stem cells associated with adhesions
14) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 1.02 Pain Relevance 0.09
The molecules LFA-1, ICAM-1, ICAM-2, and ICAM-3 are all expressed on HIV-1-infected cells, and they are also found embedded onto virions [54,55].
Gene_expression (expressed) of LFA-1 associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.17 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.86 Pain Relevance 0
There were no significant differences in Mac-1, LFA-1, or L-selectin expression by TNF-?
Gene_expression (expression) of LFA-1
16) Confidence 0.16 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.49 Pain Relevance 0
There were no significant differences in Mac-1, LFA-1, or L-selectin expression by TNF-?
Gene_expression (expression) of LFA-1
17) Confidence 0.16 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.49 Pain Relevance 0
Lovastatin treatment also attenuated the transmigration of mononuclear cells by downregulating the expression of leukocyte function antigen-1 (LFA-1), a ligand for intercellular adhesion molecule (ICAM), in endothelial-leukocyte interaction [88] and mononuclear cell infiltration into the CNS has been implicated in MS [89].
Gene_expression (expression) of LFA-1 in leukocyte associated with multiple sclerosis and adhesions
18) Confidence 0.16 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.58 Pain Relevance 0.56
In fact, as we recently demonstrated [20], CD133+ stem cells express several adhesion molecules, such as CD44, LFA-1, PSGL-1, ?
Gene_expression (adhesion) of LFA-1 in stem cells associated with adhesions
19) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 1.01 Pain Relevance 0.09
The biological effects of statins on cholesterol metabolism, Rho GTPases activity, LFA-1/ICAM-1 function and CCR5/RANTES expression can disrupt several steps of the HIV-1 life cycle, and target cell membrane interaction.
Gene_expression (expression) of LFA-1 associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.13 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox