INT61418

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Context Info
Confidence 0.14
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.86
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
myometrium 2
external 2
cervix 2
lymphocyte 1
Caco-2 1
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 10 100.00 Very High Very High Very High
Enkephalin 1 99.84 Very High Very High Very High
Opioid 2 96.64 Very High Very High Very High
cINOD 14 96.44 Very High Very High Very High
Neuropeptide 1 96.36 Very High Very High Very High
Angina 4 96.08 Very High Very High Very High
Inflammation 139 94.76 High High
cytokine 51 93.12 High High
Dynorphin 1 92.40 High High
agonist 29 83.04 Quite High
Disease Link Frequency Relevance Heat
Adhesions 54 100.00 Very High Very High Very High
Cv Unclassified Under Development 11 100.00 Very High Very High Very High
Schizophrenia 5 99.80 Very High Very High Very High
Lung Cancer 2 99.80 Very High Very High Very High
Breast Cancer 8 99.48 Very High Very High Very High
Targeted Disruption 7 98.24 Very High Very High Very High
Stress 49 97.32 Very High Very High Very High
Cv General 3 Under Development 3 96.08 Very High Very High Very High
Coronary Artery Disease 55 95.28 Very High Very High Very High
INFLAMMATION 162 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Positive_regulation (important) of CD11a associated with adhesions
1) Confidence 0.14 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.05 Pain Relevance 0
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of CD11a in cervix associated with adhesions
2) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (increased) of CD11a in cervix associated with adhesions
3) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Allelic variation in the human prodynorphin gene promoter and schizophrenia.
Positive_regulation (variation) of prodynorphin gene promoter associated with enkephalin and schizophrenia
4) Confidence 0.09 Published 2002 Journal Neuropsychobiology Section Title Doc Link 12207142 Disease Relevance 0.51 Pain Relevance 0.42
Expression of uPAR correlated with activation of beta(2)-integrins lymphocyte function-associated antigen 1 (LFA-1) and macrophage antigen 1 (Mac-1), measured by using monoclonal antibodies (mAbs) 24 and CBRM1/5.
Positive_regulation (activation) of LFA-1 in lymphocyte
5) Confidence 0.08 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.02 Pain Relevance 0.10
The baculovirus expression vector system utilizing the strong polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus (AcNPV) was used for high level expression of the two alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 in Spodoptera frugiperda (Sf-9) insect cells.
Positive_regulation (utilizing) of polyhedrin gene promoter
6) Confidence 0.07 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.15
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Positive_regulation (dependent) of LFA-1 associated with adhesions and cytokine
7) Confidence 0.05 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.65 Pain Relevance 0.05
The latter two compounds stimulated the promoter synergistically.
Positive_regulation (stimulated) of promoter
8) Confidence 0.04 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11997019 Disease Relevance 0.39 Pain Relevance 0.47
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of CD11a in myometrium associated with adhesions
9) Confidence 0.04 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (increased) of CD11a in myometrium associated with adhesions
10) Confidence 0.04 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Also upregulation of ETR101 and an integrin gene in Caco-2 cells is consistent with the results in HT29 cells.
Positive_regulation (upregulation) of integrin gene in Caco-2
11) Confidence 0.02 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0 Pain Relevance 0
This group appears not to be directly correlated with PPARG hypermethylation (our unpublished data), suggesting that methylation at this specifc gene promoter is not caused by an aberrant spread of methylation over extended genomic regions.
Neg (not) Positive_regulation (caused) of specifc gene promoter
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 1.00 Pain Relevance 0
growth of breast cancer and lung cancer cells by activating the RARE promoter
Positive_regulation (activating) of RARE promoter in lung associated with lung cancer and breast cancer
13) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.24 Pain Relevance 0.04
The crude plant extract of L. erythrorhizon as well as derived individual compounds shikonin, isobutyryl shikonin, acetyl shikonin, dimethylacryl shikonin and isovaleryl shikonin showed significant dose-dependent inhibition of TNF-alpha promoter activation.
Positive_regulation (activation) of promoter
14) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.66 Pain Relevance 0.15
Among the tested compounds, shikonin and isobutyryl shikonin exhibited the highest inhibition of TNF-alpha promoter activation and also showed significant suppression of transgenic human TNF-alpha mRNA expression and protein production.
Positive_regulation (activation) of promoter associated with targeted disruption
15) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.64 Pain Relevance 0.14
In this study, we evaluated the effects of shikonin and its derivatives on the transcriptional activation of human TNF-alpha promoter in a gene gun-transfected mouse skin system by using a luciferase reporter gene assay.
Positive_regulation (activation) of promoter in skin
16) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.72 Pain Relevance 0.18
As shown in Figure 6A all four MxA-expressing cell lines demonstrated spontaneous activation of the ISRE promoter independently of external stimulus while no constitutive activation for the IFN-beta promoter was seen.
Neg (no) Positive_regulation (activation) of promoter in external
17) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.55 Pain Relevance 0
As shown in Figure 6A all four MxA-expressing cell lines demonstrated spontaneous activation of the ISRE promoter independently of external stimulus while no constitutive activation for the IFN-beta promoter was seen.
Positive_regulation (activation) of ISRE promoter in external
18) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.56 Pain Relevance 0
The fold induction of promoter activity was calculated by dividing the normalized SEAP activity from pIFN-beta-SEAP or pISRE-SEAP transfected cells with that of control plasmid transfected cells (relative activity).


Positive_regulation (induction) of promoter
19) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0 Pain Relevance 0
Angiogenesis is induced by ischemia through the promoter Hif-1 TACGTGCT promoter and VEGF activity, whereas arteriogenesis is induced by the shear stress promotor by the shear stress responsive element (SSRE): GAGACC (figure 6) [41].
Positive_regulation (induced) of promoter associated with stress and ischemia
20) Confidence 0.01 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.33 Pain Relevance 0.22

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