INT61420

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 18.96
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Egfl7) extracellular space (Egfl7) extracellular region (Egfl7)
Anatomy Link Frequency
kidney 2
Egfl7 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 76.24 Quite High
Inflammation 52 52.64 Quite High
cva 30 5.00 Very Low Very Low Very Low
Restless leg syndrome 15 5.00 Very Low Very Low Very Low
ischemia 15 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 451 100.00 Very High Very High Very High
Diabetes Mellitus 286 100.00 Very High Very High Very High
Colon Cancer 3 99.68 Very High Very High Very High
Acute Coronary Syndrome 120 99.62 Very High Very High Very High
Cardiovascular Disease 742 99.60 Very High Very High Very High
Hepatotoxicity 1 99.32 Very High Very High Very High
Death 106 98.76 Very High Very High Very High
Hyperlipoproteinemia Type Ii 27 98.72 Very High Very High Very High
Myocardial Infarction 332 98.68 Very High Very High Very High
Peripheral Arterial Disease 151 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All serum-neu-protein-positive patients with colorectal carcinomas showed also an elevated neu protein expression.
Positive_regulation (elevated) of Gene_expression (expression) of neu protein associated with colon cancer
1) Confidence 0.12 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8576278 Disease Relevance 0.77 Pain Relevance 0.08
They suggested using statin treatment for children with heterozygous familial hypercholesterolemia, although they recommended that further assessment of lifelong safety was needed.27
Positive_regulation (using) of Gene_expression (treatment) of statin associated with hyperlipoproteinemia type ii
2) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004511 Disease Relevance 1.07 Pain Relevance 0
RhoA/ROCK pathway mediates statin-dependent enhancement of Smad activation
Positive_regulation (enhancement) of Gene_expression (pathway) of statin
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.81 Pain Relevance 0
In VSMCs, we have found that preincubation with L-mevalonate and GGPP markedly diminishes statin-induced Smad activation and overexpression of TRII and TGF-?
Positive_regulation (activation) of Gene_expression (overexpression) of statin
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.94 Pain Relevance 0.03
In VSMCs, we have found that preincubation with L-mevalonate and GGPP markedly diminishes statin-induced Smad activation and overexpression of TRII and TGF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of statin
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.94 Pain Relevance 0.03
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (-) of Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
6) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 1.05 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (for) of Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
7) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.85 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (after) of Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
8) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.85 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (after) of Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
9) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.88 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (rate) of Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
10) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.85 Pain Relevance 0
As such, lipid-lowering therapy, primarily with the HMG-CoAreductase inhibitors (statins), has become the mainstay of therapeutic guidelines for the management of these conditions.3,4 There is also a growing body of evidence supporting the benefit of statin therapy in other CVD conditions such as heart failure (HF), PVD, and chronic kidney disease (CKD).
Positive_regulation (supporting) of Gene_expression (therapy) of statin in kidney associated with chronic renal failure, cardiovascular disease, peripheral arterial disease and myocardial infarction
11) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 2.52 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (-) of Gene_expression (regimens) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
12) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.93 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (for) of Gene_expression (regimens) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
13) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.88 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (after) of Gene_expression (regimens) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
14) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.87 Pain Relevance 0
In the WOSCOPS trial, for example, less than 40% of patients in the original statin group were on a statin 5 years after the study ended.63 In one series, the greatest decline occurred during the first 6 months, and only 25% of patients maintained an acceptable level of compliance to statins 5 years after initiation of therapy.64
Positive_regulation (were) of Gene_expression (group) of statin
15) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.76 Pain Relevance 0
In the WOSCOPS trial, for example, less than 40% of patients in the original statin group were on a statin 5 years after the study ended.63 In one series, the greatest decline occurred during the first 6 months, and only 25% of patients maintained an acceptable level of compliance to statins 5 years after initiation of therapy.64
Positive_regulation (original) of Gene_expression (group) of statin
16) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.76 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (recommended) of Gene_expression (regimens) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
17) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.76 Pain Relevance 0
In the WOSCOPS trial, for example, less than 40% of patients in the original statin group were on a statin 5 years after the study ended.63 In one series, the greatest decline occurred during the first 6 months, and only 25% of patients maintained an acceptable level of compliance to statins 5 years after initiation of therapy.64
Positive_regulation (during) of Gene_expression (group) of statin
18) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.84 Pain Relevance 0
In the WOSCOPS trial, for example, less than 40% of patients in the original statin group were on a statin 5 years after the study ended.63 In one series, the greatest decline occurred during the first 6 months, and only 25% of patients maintained an acceptable level of compliance to statins 5 years after initiation of therapy.64
Positive_regulation (on) of Gene_expression (group) of statin
19) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.76 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Positive_regulation (after) of Gene_expression (regimens) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
20) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.76 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox