INT61423

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 24.96
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Egfl7) extracellular space (Egfl7) extracellular region (Egfl7)
Anatomy Link Frequency
kidney 3
thickening 2
muscle 1
heart 1
Egfl7 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 4 99.00 Very High Very High Very High
Paracetamol 7 97.72 Very High Very High Very High
cva 18 87.32 High High
Inflammation 56 81.48 Quite High
fibrosis 8 65.60 Quite High
ischemia 9 31.20 Quite Low
Pain 16 26.96 Quite Low
cytokine 8 16.16 Low Low
tolerance 16 5.00 Very Low Very Low Very Low
Restless leg syndrome 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Failure 14 99.98 Very High Very High Very High
Cardiovascular Disease 500 99.96 Very High Very High Very High
Hyperlipidemia 64 99.68 Very High Very High Very High
Cancer 205 99.66 Very High Very High Very High
Colon Cancer 12 99.50 Very High Very High Very High
Acute Coronary Syndrome 79 99.44 Very High Very High Very High
Chronic Renal Failure 135 99.36 Very High Very High Very High
Coronary Artery Disease 429 99.32 Very High Very High Very High
Stroke 300 99.26 Very High Very High Very High
Hepatotoxicity 9 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of serum neu protein expression corresponded to the clinical course and the tumour marker CA 19-9.
Gene_expression (expression) of neu protein associated with cancer
1) Confidence 0.14 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8576278 Disease Relevance 0.76 Pain Relevance 0.07
All serum-neu-protein-positive patients with colorectal carcinomas showed also an elevated neu protein expression.
Gene_expression (expression) of neu protein associated with colon cancer
2) Confidence 0.14 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8576278 Disease Relevance 0.77 Pain Relevance 0.08
We report on our experience investigating the serum levels of the soluble domain of p185 and the neu protein expression in the corresponding tumour tissue in patients with advanced gastrointestinal carcinomas.
Gene_expression (expression) of neu protein associated with cancer and carcinoma
3) Confidence 0.14 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8576278 Disease Relevance 0.51 Pain Relevance 0.09
The serum levels of the neu protein were investigated by immunosorbent assay techniques.
Spec (investigated) Gene_expression (levels) of neu protein
4) Confidence 0.11 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8576278 Disease Relevance 0.63 Pain Relevance 0.10
They suggested using statin treatment for children with heterozygous familial hypercholesterolemia, although they recommended that further assessment of lifelong safety was needed.27
Gene_expression (treatment) of statin associated with hyperlipoproteinemia type ii
5) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004511 Disease Relevance 1.07 Pain Relevance 0
They found that this difference was statistically significant at 40 mg/day of simvastatin.45

Statin therapy: meta-analyses

Spec (analyses) Gene_expression (therapy) of Statin
6) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004511 Disease Relevance 0.42 Pain Relevance 0
SANDS was a long term trial in Type II diabetics, with the goal of using aggressive LDL-C lowering to <71 mg/dL to reduce carotid IMT.30 SANDS was designed to evaluate LDL-C lowering directly, producing it with statin alone if possible but with the addition of ezetimibe 10 mg when it was needed.
Gene_expression (producing) of statin associated with diabetes mellitus
7) Confidence 0.05 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.17 Pain Relevance 0
In VSMCs, we have found that preincubation with L-mevalonate and GGPP markedly diminishes statin-induced Smad activation and overexpression of TRII and TGF-?
Gene_expression (overexpression) of statin
8) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.94 Pain Relevance 0.03
Recent studies suggests that statin-induced cholesterol lowering effects could increase TGF-?
Spec (suggests) Gene_expression (suggests) of statin
9) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.65 Pain Relevance 0.07
These results indicate that a farnesylated protein can partially inhibit Statin/TGF-?
Gene_expression (/) of Statin
10) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.77 Pain Relevance 0
RhoA/ROCK pathway mediates statin-dependent enhancement of Smad activation
Gene_expression (pathway) of statin
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.81 Pain Relevance 0
The regression in carotid intima media thickening, or CIMT, was the same whether statin alone or statin plus ezetimibe produced the aggressive LDL-C lowering.
Gene_expression (produced) of statin in thickening
12) Confidence 0.05 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.15 Pain Relevance 0
They can produce modest elevation in liver enzymes, but there has never been a clearly documented case of liver failure produced by a statin, in contrast to a number of cases of liver failure from acetaminophen.16–18 While there is a risk of muscle problems with the statins, this risk is modest and usually manageable.
Neg (failure) Gene_expression (produced) of statin in muscle associated with liver failure and paracetamol
13) Confidence 0.05 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.67 Pain Relevance 0.13
Also, several studies have shown that, in contrast with elevated triglycerides, low HDL-C remains a risk factor for cardiac events even with most traditional levels of statin therapy.48,49 The one exception was from a recent secondary analysis from the JUPITER study, which lowered LDL-C levels down to the 50–55 mg/dL range.
Gene_expression (levels) of statin associated with hypertriglyceridemia and disorder of lipid metabolism
14) Confidence 0.05 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.94 Pain Relevance 0
The patients were already on background statin therapy, predominantly simvastatin and atorvastatin, and their LDL-C must have been <100 mg/dL, with an HDL-C of <50 mg/dL in men and <55 mg/dL in women.
Gene_expression (therapy) of statin associated with disorder of lipid metabolism
15) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.63 Pain Relevance 0
The regression in carotid intima media thickening, or CIMT, was the same whether statin alone or statin plus ezetimibe produced the aggressive LDL-C lowering.
Spec (whether) Gene_expression (produced) of statin in thickening
16) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.15 Pain Relevance 0
Also, since the study was completed over 35 years ago, when statin therapy was in the distant future, what does this unclear data say to us now?
Gene_expression (therapy) of statin
17) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.27 Pain Relevance 0
Among low risk patients, on the other hand, statin therapy was associated with a 51% reduction in ischemic stroke in the JUPITER primary prevention trial.31
Gene_expression (therapy) of statin associated with stroke
18) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 1.38 Pain Relevance 0.04
Furthermore, statin therapy has already been an integral part of the standard management of diabetes mellitus, a major CVD risk factor and CHD-equivalent.5
Gene_expression (therapy) of statin associated with coronary artery disease, cardiovascular disease and diabetes mellitus
19) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 2.26 Pain Relevance 0
In patients with CHD, in a recent survey a 26% rate of noncompliance to statins was found, which was in turn associated with an 85% increase in overall mortality.65 Among those who had ACS, the continuation rate for statin drops to 44% after 3 years.66 Similarly, the stroke survivors’ adherence to recommended statin regimens rapidly declines after hospital discharge, and barely half of these patients remain on treatment after 2 years.67 Diabetics are not faring any better, with less than half of patients maintaining a satisfactory degree of long-term statin adherence.68
Gene_expression (drops) of statin associated with acute coronary syndrome, coronary artery disease, diabetes mellitus and stroke
20) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.85 Pain Relevance 0

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