INT61429

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.49
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adcy5) lyase activity (Adcy5) plasma membrane (Adcy5)
cilium (Adcy5)
Anatomy Link Frequency
striatum 2
nucleus accumbens 1
caudate-putamen 1
Adcy5 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 9 99.24 Very High Very High Very High
Nucleus accumbens 4 98.40 Very High Very High Very High
Dopamine 8 97.60 Very High Very High Very High
mu opioid receptor 4 75.00 Quite High
Neurotransmitter 2 66.68 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 80 98.60 Very High Very High Very High
Stress 2 97.20 Very High Very High Very High
Disease 16 96.44 Very High Very High Very High
Aging 60 95.48 Very High Very High Very High
Obesity 42 62.88 Quite High
Weight Gain 2 7.44 Low Low
Hyperinsulinism 10 6.40 Low Low
Body Weight 30 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Fatty Liver 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, it is of interest that disruption of the AC isoform type 5 adenylyl cyclase (AC5) in mice was reported to increase lifespan and resistance to cardiac stress in mice [5].
Gene_expression (disruption) of AC5 associated with stress and lifespan
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 0.75 Pain Relevance 0.03
In this regard, it is of interest that disruption of the AC isoform type 5 adenylyl cyclase (AC5) in mice was reported to increase lifespan and resistance to cardiac stress in mice [5].
Gene_expression (disruption) of isoform type 5 adenylyl cyclase associated with stress and lifespan
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 0.75 Pain Relevance 0.03
Among these isoforms, AC5 and PDE7B are highly expressed in striatum, where the cAMP pathway is implicated in diverse behavioural functions.
Gene_expression (expressed) of AC5 in striatum
3) Confidence 0.39 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.21
We found co-expression of AC5 and PDE7B mRNAs in caudate-putamen and nucleus accumbens; we also encountered that more than 50% of MOR, D2- and D1-expressing cells contained AC5 and PDE7B mRNAs.
Gene_expression (expression) of AC5 in caudate-putamen associated with nucleus accumbens
4) Confidence 0.34 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.33
We performed a double in situ hybridization analysis of the co-expression patterns of AC5 and PDE7B with mu-opioid-receptor (MOR), D1- and D2-receptor mRNAs to contribute to a better understanding in the regulation of cAMP levels under dopamine or opioidergic pathway activation in striatum.
Gene_expression (expression) of AC5 in striatum associated with dopamine and opioid
5) Confidence 0.34 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.26
We found co-expression of AC5 and PDE7B mRNAs in caudate-putamen and nucleus accumbens; we also encountered that more than 50% of MOR, D2- and D1-expressing cells contained AC5 and PDE7B mRNAs.
Gene_expression (expression) of AC5 in nucleus accumbens associated with nucleus accumbens
6) Confidence 0.12 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.33
The presence of Ac5c or Ac3c in place of Phe3 further diminished Ki delta (15.4 to 19.0 nM), yet delta selectivity only fell about one-half (Ki mu/Ki delta = 440 and 535, respectively), and only the former peptide fitted a two-site binding model (eta = 0.799).
Gene_expression (presence) of Ac5c
7) Confidence 0.02 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8576920 Disease Relevance 0 Pain Relevance 0.07

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