INT61434

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Context Info
Confidence 0.26
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Nf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.80 Very High Very High Very High
antagonist 4 99.14 Very High Very High Very High
Opioid 4 98.92 Very High Very High Very High
opiate 4 98.60 Very High Very High Very High
Morphine 10 97.60 Very High Very High Very High
narcan 12 96.68 Very High Very High Very High
Peripheral nervous system 1 82.64 Quite High
addiction 2 65.84 Quite High
tolerance 2 65.24 Quite High
Endogenous opioid 2 53.28 Quite High
Disease Link Frequency Relevance Heat
Watson Syndrome 5 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Syndrome 1 100.00 Very High Very High Very High
Benign Tumor 1 85.68 High High
Neurofibroma 2 84.32 Quite High
Pruritus 1 76.32 Quite High
Malignant Neoplastic Disease 5 75.00 Quite High
Brachial Plexus Neuropathies 1 75.00 Quite High
Plexiform Neurofibroma 2 67.04 Quite High
Pain 1 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opposite trend of the changes in opiate drug and opioid antagonist animals suggests opioid receptor-mediated regulation of Oct-1 and CTF/NF1 transcription factors.
Regulation (regulation) of NF1 associated with antagonist, opioid receptor, opiate and opioid
1) Confidence 0.26 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8577206 Disease Relevance 0 Pain Relevance 1.08
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome affecting approximately 1 in 4,000 persons.
Regulation (affecting) of Neurofibromatosis type 1 associated with syndrome, cancer and watson syndrome
2) Confidence 0.25 Published 2006 Journal Muscle Nerve Section Abstract Doc Link 16323217 Disease Relevance 1.39 Pain Relevance 0.09
The binding activity of CTF/NF1 changes differently showed higher levels assessed 30-120 min after morphine administration.
Regulation (changes) of NF1 associated with morphine
3) Confidence 0.19 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8577206 Disease Relevance 0 Pain Relevance 1.23

General Comments

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