INT61441

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Context Info
Confidence 0.10
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.69
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
skin 3
spinal cord 2
hair follicles 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 17 100.00 Very High Very High Very High
melanocortin 1 receptor 6 100.00 Very High Very High Very High
Clonidine 7 99.98 Very High Very High Very High
Sciatic nerve 1 99.72 Very High Very High Very High
dorsal rhizotomy 2 98.70 Very High Very High Very High
Spinal cord 3 98.40 Very High Very High Very High
antagonist 2 90.40 High High
agonist 1 88.76 High High
B1 receptor 1 88.44 High High
Rostral ventrolateral medulla 1 86.64 High High
Disease Link Frequency Relevance Heat
Hypotension 3 98.28 Very High Very High Very High
Body Weight 4 93.20 High High
Cytomegalovirus Infection 2 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of Gene_expression (expression) of tyrosinase in skin associated with melanocortin 1 receptor
1) Confidence 0.10 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of in hair follicles Gene_expression (expression) of tyrosinase in skin associated with melanocortin 1 receptor
2) Confidence 0.03 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
Two weeks after unilateral lumbar dorsal rhizotomy (L1-L6) or peripheral lesions of the sciatic nerve, significant decreases ( +/- 50%) in [125I-Tyr8]bradykinin binding sites were found in ipsilateral laminae I-III of lumbar spinal cord.
Negative_regulation (decreases) of Gene_expression (found) of Tyr8 in spinal cord associated with dorsal rhizotomy, sciatic nerve, bradykinin and spinal cord
3) Confidence 0.02 Published 1995 Journal Neuroscience Section Abstract Doc Link 8577380 Disease Relevance 0 Pain Relevance 1.18
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Negative_regulation (attenuated) of Gene_expression (expression) of cRVLM associated with hypotension and clonidine
4) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.18 Pain Relevance 0.72

General Comments

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