INT61446

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Glial cell 1
IB4 1
DRG 1
nociceptors 1
Lgals4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 1 100.00 Very High Very High Very High
intrathecal 1 99.84 Very High Very High Very High
dorsal root ganglion 5 99.74 Very High Very High Very High
Neuropeptide 7 99.28 Very High Very High Very High
nociceptor 4 98.74 Very High Very High Very High
Hyperalgesia 5 95.48 Very High Very High Very High
antagonist 4 94.72 High High
Neuropathic pain 3 91.12 High High
Spinal cord 2 89.80 High High
Dorsal horn 1 87.20 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.74 Very High Very High Very High
Hyperalgesia 7 98.32 Very High Very High Very High
Nociception 4 92.32 High High
Neuropathic Pain 3 91.12 High High
Injury 3 88.72 High High
Tooth Injuries 2 78.96 Quite High
Hypersensitivity 1 31.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lectin IB4, a marker of primary afferent C fibres, showed a qualitative decrease in staining intensity in laminae 1-2 with ligation compared with both the unoperated contralateral side and with sham animals.
Lectin IB4 Binding (ligation) of in IB4 associated with c fibre
1) Confidence 0.03 Published 1995 Journal Pain Section Abstract Doc Link 8577486 Disease Relevance 0.27 Pain Relevance 0.56
Immunohistochemistry demonstrated the presence of M2R and M3R in medium-sized lumbar DRG neurons that also coexpressed binding sites for the lectin I-B4, a marker for mainly cutaneous nociceptors.
lectin I-B4 Binding (binding) of in DRG associated with nociceptor
2) Confidence 0.03 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 11024086 Disease Relevance 0.17 Pain Relevance 0.26
Glial cell line-derived neurotrophic factor (GDNF) is necessary for the development of sensory neurons, and appears to be critical for the survival of dorsal root ganglion (DRG) cells that bind the lectin IB4.
lectin IB4 Binding (bind) of in Glial cell associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 14568039 Disease Relevance 0.72 Pain Relevance 0.60
Most pulpal afferent neurons have cytochemical features in common with the class of nociceptors that express neuropeptides and respond to NGF, while very few bind the plant lectin IB4, a widely used marker for the class of nociceptors that respond to the GDNF family of neurotrophic factors.
lectin IB4 Binding (bind) of in nociceptors associated with nociceptor and neuropeptide
4) Confidence 0.02 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16444814 Disease Relevance 0.14 Pain Relevance 0.28

General Comments

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