INT61452

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 7.21
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1RAP) extracellular region (IL1RAP) plasma membrane (IL1RAP)
intracellular (IL1RAP) protein complex assembly (IL1RAP) signal transducer activity (IL1RAP)
Anatomy Link Frequency
synovial fluid 1
immune cell 1
PSCs 1
pancreas 1
intervertebral disc 1
IL1RAP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 48 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
vaginimus 6 100.00 Very High Very High Very High
Infliximab 1 100.00 Very High Very High Very High
Adalimumab 1 100.00 Very High Very High Very High
Etanercept 1 100.00 Very High Very High Very High
Chronic pancreatitis 6 99.76 Very High Very High Very High
Angina 6 99.72 Very High Very High Very High
anakinra 1 99.48 Very High Very High Very High
Inflammatory response 4 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 14 100.00 Very High Very High Very High
Cancer 14 100.00 Very High Very High Very High
Dyspareunia 3 100.00 Very High Very High Very High
Pancreatitis 6 99.76 Very High Very High Very High
Stable Angina Pectoris 6 99.72 Very High Very High Very High
Fibrosis 7 99.34 Very High Very High Very High
Headache 10 98.16 Very High Very High Very High
INFLAMMATION 43 98.04 Very High Very High Very High
Temporomandibular Joint Disorders 2 97.44 Very High Very High Very High
Coronary Artery Disease 8 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSCs expressed soluble ST2, ST2L, and IL-1RAcP, but the expression level of ST2L was relatively low.
Gene_expression (expressed) of IL-1RAcP in PSCs
1) Confidence 0.58 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.33 Pain Relevance 0.13
Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-alpha (infliximab, adalimumab, etanercept) and an interleukin-1 receptor antagonist (anakinra), with many more in development.
Gene_expression (activity) of interleukin-1 receptor associated with anakinra, necrosis, infliximab, cancer, antagonist, adalimumab and etanercept
2) Confidence 0.19 Published 2005 Journal South. Med. J. Section Abstract Doc Link 15759950 Disease Relevance 1.13 Pain Relevance 0.57
Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

Data implicate IL-1 in the altered matrix biology that characterizes human intervertebral disc (IVD) degeneration.

Gene_expression (delivered) of Interleukin-1 receptor in intervertebral disc associated with antagonist
3) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.09
RESULTS: IL33, ST2L and IL1RAcP were expressed by alpha-SMA-positive myofibroblasts in the fibrosis of chronic pancreatitis.
Gene_expression (expressed) of IL1RAcP
4) Confidence 0.16 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.08 Pain Relevance 0
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Gene_expression (Expression) of IL1RAcP associated with cytokine
5) Confidence 0.16 Published 2010 Journal Gut Section Title Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0.24
To define the role of IL33 in fibrogenesis of the pancreas, the expression of IL33, ST2L and IL1RAcP was examined in chronic pancreatitis tissues.
Spec (examined) Gene_expression (expression) of IL1RAcP in pancreas associated with fibrosis and chronic pancreatitis
6) Confidence 0.16 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.20 Pain Relevance 0.18
The expression of IL33, ST2L and IL1RAcP was evaluated by standard immunohistochemical procedures.
Gene_expression (expression) of IL1RAcP
7) Confidence 0.16 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
Messenger RNA expression for IL33, ST2L and IL1RAcP was analysed by northern blotting and real-time PCR analyses, and protein expression was assessed by western blotting and ELISA.
Spec (analysed) Gene_expression (expression) of IL1RAcP
8) Confidence 0.16 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
There is a genetic profile of women suffering of vulvodynia, especially genetic polymorphisms from genes coding for cytokines, Interleukin-1 receptor antagonist and Interleukin-1 beta, and gene coding for mannose-binding lectin (MBL).
Gene_expression (profile) of Interleukin-1 receptor associated with vaginimus, antagonist and cytokine
9) Confidence 0.10 Published 2008 Journal J Med Life Section Abstract Doc Link 20108524 Disease Relevance 0.90 Pain Relevance 0.80
Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early increase in the interleukin-1 receptor antagonist levels at the end of surgery was seen.
Gene_expression (detectable) of interleukin-1 receptor associated with necrosis, cancer and antagonist
10) Confidence 0.09 Published 1998 Journal Eur J Anaesthesiol Section Abstract Doc Link 9522142 Disease Relevance 0.37 Pain Relevance 0.50
has been demonstrated for the increased production of IL-1 receptor antagonist in human neutrophils [37].
Gene_expression (production) of IL-1 receptor in neutrophils associated with antagonist
11) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.67 Pain Relevance 0.21
Interleukin 1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-1 receptor antagonist protein, and substance P were not detected in the culture media of either the herniated or control discs.
Neg (not) Gene_expression (detected) of interleukin-1 receptor
12) Confidence 0.02 Published 1996 Journal Spine Section Body Doc Link 8742201 Disease Relevance 0 Pain Relevance 0
Interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-1 receptor antagonist protein, and substance P were not detected in the culture media of the herniated or control discs.
Neg (not) Gene_expression (detected) of interleukin-1 receptor
13) Confidence 0.02 Published 1995 Journal Spine Section Body Doc Link 8578386 Disease Relevance 0 Pain Relevance 0
High levels of C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist in patients were significantly related to numbers of neutrophils and neutrophil-platelet aggregates but not to other immune cell subpopulations.
Gene_expression (levels) of interleukin-1 receptor in immune cell associated with antagonist
14) Confidence 0.02 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 15695127 Disease Relevance 0.76 Pain Relevance 0.50
Circulating levels of C-reactive protein, interleukin-1 receptor antagonist, interleukin-2 receptor, interleukin-6, interleukin-10, and interleukin-18 were determined.
Gene_expression (levels) of interleukin-1 receptor associated with antagonist
15) Confidence 0.02 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 15695127 Disease Relevance 0.87 Pain Relevance 0.43
Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.
Gene_expression (Analysis) of interleukin-1 receptor in synovial fluid associated with necrosis, snapping jaw, cancer, antagonist and cytokine
16) Confidence 0.01 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 15716832 Disease Relevance 0.50 Pain Relevance 0.53
There was no change with respect to IL-IR 1 receptor expression values.
Gene_expression (expression) of IL-IR 1 receptor
17) Confidence 0.01 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9231885 Disease Relevance 1.13 Pain Relevance 0.91

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