INT61464

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.72
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
osteoclast 1
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 97.12 Very High Very High Very High
cytokine 14 95.40 Very High Very High Very High
Arthritis 74 85.40 High High
Inflammation 72 50.00 Quite Low
Analgesic 1 25.00 Low Low
antagonist 8 11.92 Low Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 14 98.96 Very High Very High Very High
Pressure And Volume Under Development 18 87.28 High High
Arthritis 106 85.40 High High
Disease 44 59.72 Quite High
INFLAMMATION 60 50.00 Quite Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Arthropathy 10 5.00 Very Low Very Low Very Low
Dengue 6 5.00 Very Low Very Low Very Low
Osteoporosis 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin treatment had little effect on TRAP mRNA levels.
Neg (little) Regulation (effect) of TRAP mRNA
1) Confidence 0.59 Published 1995 Journal Bone Section Abstract Doc Link 8579955 Disease Relevance 0 Pain Relevance 0
The apparent regulation of the TRAP, RANKL, ATPV0D2, and MMP9 expression after anti–MDL-1 treatment suggests MDL-1 receptor activation may promote osteoclast development and function.
Regulation (regulation) of TRAP in osteoclast
2) Confidence 0.06 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.21
Importantly, genes associated with bone destruction such as RANKL, MMP9, ATPV0D2, and TRAP are down-regulated in paws after MDL-1–Ig fusion treatment and up-regulated in anti–MDL-1 agonist treatment.
Regulation (regulated) of TRAP associated with agonist
3) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.39 Pain Relevance 0.29

General Comments

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