INT61465

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.06
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
osteoclast 6
tibia 1
cartilage 1
bone marrow 1
parathyroid 1
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 121 99.20 Very High Very High Very High
aspirin 126 99.08 Very High Very High Very High
Catecholamine 7 98.38 Very High Very High Very High
cytokine 83 96.64 Very High Very High Very High
Clonidine 1 95.56 Very High Very High Very High
agonist 80 92.36 High High
Inflammation 219 91.80 High High
Arthritis 203 87.04 High High
antagonist 27 64.96 Quite High
imagery 22 55.68 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 96 100.00 Very High Very High Very High
Rheumatoid Arthritis 121 99.20 Very High Very High Very High
Cancer 161 96.76 Very High Very High Very High
Systemic Lupus Erythematosus 35 96.12 Very High Very High Very High
Osteoporosis 352 95.40 Very High Very High Very High
Arthritis 277 94.48 High High
Pressure And Volume Under Development 48 93.84 High High
Fracture Healing 66 92.48 High High
INFLAMMATION 189 89.44 High High
Bone Cancer 10 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate homologous regulation of the CTR, and regulation of TRAP expression in osteoclast-like cells after brief treatment with salmon CT (sCT).
Gene_expression (expression) of TRAP in osteoclast
1) Confidence 0.75 Published 1995 Journal Bone Section Abstract Doc Link 8579955 Disease Relevance 0 Pain Relevance 0
TRAP activity is expressed as hydrolysis of 1 ?
Gene_expression (expressed) of TRAP
2) Confidence 0.64 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0 Pain Relevance 0
After 9 days, TRAP-expressing multi-nucleated OCs was scored.



Gene_expression (expressing) of TRAP
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0 Pain Relevance 0.09
Histology and tartrate-resistant acid phosphatase staining
Gene_expression (staining) of tartrate-resistant acid phosphatase
4) Confidence 0.22 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1557720 Disease Relevance 0.42 Pain Relevance 0
Interestingly, even through MDL-1 activation enhanced TNF, IL-6, RANK, and TRAP expression, both type I and II IFNs were undetectable in the inflamed paws (the Q-PCR cycle threshold is ?
Gene_expression (expression) of TRAP
5) Confidence 0.18 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.37 Pain Relevance 0.26
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Gene_expression (expression) of TRAP in osteoclasts associated with hypercalcemia
6) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.08 Pain Relevance 0.28
Apart from this late-differentiation marker, early-differentiation markers for osteoclastogenesis, such as cathepsin K and tartrate-resistant acid phosphatase, are also expressed in the synovium of RA.
Gene_expression (expressed) of tartrate-resistant acid phosphatase in synovium associated with rheumatoid arthritis
7) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.31 Pain Relevance 0.15
After TRAP staining, TRAP-positive multinucleated cells (>3 nuclei) were counted as osteoclast-like cells.


Gene_expression (counted) of TRAP in osteoclast
8) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0.14 Pain Relevance 0
In contrast, neutralization of MDL-1 function down-regulates TRAP, cathepsin K, and MMP9 expression, subsequently preserving bone mineral density.
Gene_expression (expression) of TRAP
9) Confidence 0.14 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.51 Pain Relevance 0.25
After TRAP staining, TRAP-positive multinucleated cells (>3 nuclei) were counted as osteoclast-like cells.


Gene_expression (staining) of TRAP in osteoclast
10) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0.08 Pain Relevance 0
CTK and TRAP mRNA were detected in multinucleated cells attached to bone/cartilage surfaces.
Gene_expression (detected) of TRAP mRNA in cartilage
11) Confidence 0.13 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.16 Pain Relevance 0
Mature osteoclasts express the IL-4 receptor, and exogenous IL-4 decreased tartrate-resistant acid phosphatase expression, actin ring formation, and bone resorption by osteoclasts [82].
Gene_expression (expression) of tartrate-resistant acid phosphatase in osteoclasts associated with hypercalcemia
12) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.41 Pain Relevance 0.21
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Gene_expression (transferase) of TRAP in regulatory T cells associated with systemic lupus erythematosus
13) Confidence 0.12 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
Histological sections showed a marked decrease in TRAP-positive cells in the tibia of aspirin treated OVX mice in comparison to the OVX and sham mice (Fig. 4B).
Gene_expression (positive) of TRAP in tibia associated with aspirin
14) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0.05 Pain Relevance 0.41
Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells.
Gene_expression (production) of TRAcP associated with catecholamine
15) Confidence 0.11 Published 1996 Journal Osteoporos Int Section Abstract Doc Link 8845594 Disease Relevance 0 Pain Relevance 0.39
Against the background of only minor differences in the synthesis and protein expression of OPN, BSP, TRAP, and CTK in callus between OVX-D and sham-treated animals, our results suggest that the molecular composition of the fracture callus is not markedly skewed in OP.


Gene_expression (expression) of TRAP associated with osteoporosis
16) Confidence 0.11 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.58 Pain Relevance 0
Ratios for TRAP or CTK did not differ between the two groups.
Gene_expression (Ratios) of TRAP
17) Confidence 0.11 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.06 Pain Relevance 0
Mouse spleen cells and bone marrow macrophages express IL-4 and IL-13 receptors, and the addition of these factors decreased RANKL-stimulated tartrate-resistant acid phosphatase-positive multi-nucleated cell formation and cathepsin K message in spleno-cytes and bnone marrow macrophages [80].
Gene_expression (message) of tartrate-resistant acid phosphatase in bone marrow
18) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.53 Pain Relevance 0.23
mRNA expression for OPN, BSP, TRAP, and CTK in cell types was distributed as previously described in intact bone tissue [21, 26, 43].
Gene_expression (expression) of TRAP in bone tissue
19) Confidence 0.10 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.40 Pain Relevance 0.03
A minimum of four images were sampled in each predetermined region according to our previous experience with protein distribution for BSP, OPN, TRAP, and CTK [26, 27].
Gene_expression (sampled) of TRAP
20) Confidence 0.10 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.09 Pain Relevance 0.03

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