INT61466

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 25
Disease Relevance 10.17
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
osteoclast 14
osteoblast 3
parathyroid 1
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 15 100.00 Very High Very High Very High
Catecholamine 7 99.32 Very High Very High Very High
Clonidine 1 97.44 Very High Very High Very High
agonist 60 89.60 High High
aspirin 42 75.20 Quite High
cytokine 27 68.80 Quite High
Arthritis 111 67.72 Quite High
antagonist 12 50.60 Quite High
Inflammation 110 50.00 Quite Low
fibrosis 3 44.08 Quite Low
Disease Link Frequency Relevance Heat
Hypercalcemia 72 99.40 Very High Very High Very High
Disease 154 99.20 Very High Very High Very High
Apoptosis 150 99.04 Very High Very High Very High
Osteoporosis 494 98.70 Very High Very High Very High
Targeted Disruption 286 98.28 Very High Very High Very High
Metastasis 4 97.72 Very High Very High Very High
Bone Disease 36 95.08 Very High Very High Very High
Breast Cancer 4 84.80 Quite High
Muscle Weakness 51 83.60 Quite High
Cancer 16 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2, there was a significant increase of TRAP activity at days 7 and 10 of osteoclast differentiation, indicating that the mononucleated cells differentiated into osteoclasts.
Positive_regulation (increase) of TRAP in osteoclasts
1) Confidence 0.66 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.25 Pain Relevance 0
During the TRAP assay, only mononucleated cells showed an increase of TRAP activity starting from day 3 of osteoclast differentiation induction.
Positive_regulation (increase) of TRAP in osteoclast
2) Confidence 0.66 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.31 Pain Relevance 0
We performed a TRAP assay to detect the degree of osteoclast differentiation in both cell lines and found that TRAP activity was significantly increased only in mononucleated primary cells.
Positive_regulation (increased) of TRAP in osteoclast
3) Confidence 0.66 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.58 Pain Relevance 0
These data are in accord with the findings of Intan Zarina et al [13,14], who reported that TRAP activity is increased at day 10 of osteoclast differentiation.
Positive_regulation (increased) of TRAP in osteoclast
4) Confidence 0.66 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.56 Pain Relevance 0
There was no difference in the numbers of multinucleated TRAP(+) osteoclast-like cells between treated and control cells.
Positive_regulation (multinucleated) of TRAP in osteoclast
5) Confidence 0.48 Published 1995 Journal Bone Section Abstract Doc Link 8579955 Disease Relevance 0 Pain Relevance 0
Two different biochemical assays were carried out to measure osteoblast and osteoclast differentiations: alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRAP) assays.
Positive_regulation (tartrate) of TRAP in osteoclast associated with osteoporosis
6) Confidence 0.47 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.39 Pain Relevance 0
This result was similar to that of Perez-Amodio et al [26], who found fluctuating TRAP activity during the first 7 days of osteoblast differentiation.
Positive_regulation (fluctuating) of TRAP in osteoblast associated with osteoporosis
7) Confidence 0.47 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.49 Pain Relevance 0
Nevertheless, only mononucleated cells showed the significant increase in TRAP activity characteristic of mature osteoclasts.
Positive_regulation (increase) of TRAP in osteoclasts
8) Confidence 0.44 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2984396 Disease Relevance 0.09 Pain Relevance 0
They proposed that the fluctuation of TRAP activity may have been caused by the activation and deactivation of TRAP by cysteine proteinases [27].
Positive_regulation (activation) of TRAP
9) Confidence 0.44 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.43 Pain Relevance 0
Two different biochemical assays were carried out to measure osteoblast and osteoclast differentiations: alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRAP) assays.
Positive_regulation (tartrate) of resistant acid phosphatase in osteoclast associated with osteoporosis
10) Confidence 0.41 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.39 Pain Relevance 0
Evaluation of tartrate-resistant acid phosphatase (TRACP) 5b as bone resorption marker in irradiated bone metastases.
Positive_regulation (Evaluation) of tartrate-resistant acid phosphatase associated with pain, hypercalcemia and metastasis
11) Confidence 0.37 Published 2005 Journal Anticancer Res. Section Title Doc Link 16334155 Disease Relevance 0.20 Pain Relevance 0.20
The number of TRAP stained osteoclasts expressed as number per unit of bone area was increased with both pamidronate doses compared to vehicle treated control mice.
Positive_regulation (increased) of TRAP in osteoclasts
12) Confidence 0.35 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703200 Disease Relevance 0.24 Pain Relevance 0
The increase in TRAP positive multinucleated cells observed in knock-in mice suggested increased osteoclastogenesis associated with Paget-like disease of bone (Figure 6H).


Positive_regulation (increase) of TRAP associated with targeted disruption and bone disease
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.53 Pain Relevance 0
Pamidronate treatment increased TRAP stained osteoclast numbers yet decreased cathepsin K indicating that pamidronate repressed osteoclast maturation and function.
Positive_regulation (increased) of TRAP in osteoclast
14) Confidence 0.30 Published 2008 Journal The Open Orthopaedics Journal Section Abstract Doc Link PMC2703200 Disease Relevance 0.25 Pain Relevance 0
MicroCT analyses show increased bone activity, cortical thickness and bone histology showed osteoclastogenesis and increased TRAP (Tartrate Resistant Acid Phosphatase) staining seen in Paget-like bone lesions.
Positive_regulation (increased) of TRAP
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.92 Pain Relevance 0
MicroCT analyses show increased bone activity, cortical thickness and bone histology showed osteoclastogenesis and increased TRAP (Tartrate Resistant Acid Phosphatase) staining seen in Paget-like bone lesions.
Positive_regulation (increased) of Resistant Acid Phosphatase
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.94 Pain Relevance 0
Two different biochemical assays were carried out to measure osteoblast and osteoclast differentiations: alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRAP) assays.
Positive_regulation (tartrate) of TRAP in osteoblast associated with osteoporosis
17) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.39 Pain Relevance 0
By testing serum samples during the course of disease, we found that the osteoclast-specific TRAP 5b levels were significantly increased after MDL-1 receptor activation (Fig. 4 C).
Positive_regulation (increased) of TRAP in osteoclast associated with disease
18) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.33 Pain Relevance 0.20
Two different biochemical assays were carried out to measure osteoblast and osteoclast differentiations: alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRAP) assays.
Positive_regulation (tartrate) of resistant acid phosphatase in osteoblast associated with osteoporosis
19) Confidence 0.14 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.39 Pain Relevance 0
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (activation) of tartrate-resistant acid phosphatase in osteoclast
20) Confidence 0.13 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.38 Pain Relevance 0

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