INT6148

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Context Info
Confidence 0.42
First Reported 1981
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 34
Disease Relevance 10.17
Pain Relevance 12.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synaptic vesicles 6
spinal cord 3
hypothalamus 3
adrenal glands 2
pituitary 2
Nrtim1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 48 100.00 Very High Very High Very High
substance P 25 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
Spinal cord 12 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 5 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
qutenza 31 99.98 Very High Very High Very High
MU agonist 1 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 3 100.00 Very High Very High Very High
Urological Neuroanatomy 36 99.90 Very High Very High Very High
Depression 2 99.84 Very High Very High Very High
Cv Unclassified Under Development 6 99.72 Very High Very High Very High
Ganglion Cysts 8 99.54 Very High Very High Very High
Shock 2 99.12 Very High Very High Very High
Hyperalgesia 9 98.32 Very High Very High Very High
Stress 12 97.44 Very High Very High Very High
Increased Venous Pressure Under Development 65 96.52 Very High Very High Very High
Fever 3 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin produced a prompt release of substance P-like immunoreactivity (SP-LI) from superfused mucosa-free muscle strips excised from the guinea-pig urinary bladder.
Gene_expression (produced) of immunoreactivity in muscle associated with qutenza and substance p
1) Confidence 0.42 Published 1989 Journal Gen. Pharmacol. Section Abstract Doc Link 2473939 Disease Relevance 0 Pain Relevance 0.58
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in pituitary associated with enkephalin
2) Confidence 0.10 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in pituitary associated with enkephalin
3) Confidence 0.10 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Immunoreactivity was visualized using an ABC Elite kit according to the manufacturer's protocol and the sections were then stained for 5–7?
Gene_expression (visualized) of Immunoreactivity
4) Confidence 0.10 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0 Pain Relevance 0.06
All retrogradely labeled jejunal afferents expressing NOS-immunoreactivity (64%) also expressed TRPV1 and CGRP and most expressed SP.
Gene_expression (expressing) of NOS-immunoreactivity associated with substance p, calcitonin gene-related peptide and neuronal nitric oxide synthase
5) Confidence 0.06 Published 2008 Journal Neuroscience Section Abstract Doc Link 18706490 Disease Relevance 0.32 Pain Relevance 0.82
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in hypothalamus associated with enkephalin
6) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in adrenal glands associated with enkephalin
7) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in hypothalamus associated with enkephalin
8) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in pancreas associated with enkephalin
9) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in pancreas associated with enkephalin
10) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
Levels of methionine-enkephalin immunoreactivity (MEI) and beta-endorphin immunoreactivity (BEI) were measured by means of a specific RIA in pituitary, hypothalamus, pancreas, and adrenal glands of db/db and control mice.
Gene_expression (Levels) of immunoreactivity in adrenal glands associated with enkephalin
11) Confidence 0.04 Published 1985 Journal Endocrinology Section Abstract Doc Link 3155453 Disease Relevance 0.08 Pain Relevance 0.17
The effect of diclofenac on the expression of spinal cord c-fos-like immunoreactivity after ischemia-reperfusion-induced acute hyperalgesia in the rat tail.
Gene_expression (expression) of immunoreactivity in tail associated with hyperalgesia, ischemia, diclofenac and spinal cord
12) Confidence 0.01 Published 2000 Journal Anesth. Analg. Section Title Doc Link 10781468 Disease Relevance 0.53 Pain Relevance 0.58
We studied how this stimulus affected the expression of c-fos-like immunoreactivity (c-fos-LI) labeling of neurons of the sacral spinal cord, and how diclofenac pretreatment influenced the outcome.
Gene_expression (expression) of immunoreactivity in spinal cord associated with diclofenac and spinal cord
13) Confidence 0.01 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10781468 Disease Relevance 0.43 Pain Relevance 0.50
Relaxin immunoreactivity (RXN-IR) was detected in all samples by a pig relaxin RIA and diluted in parallel with the standard curve.
Gene_expression (detected) of immunoreactivity
14) Confidence 0.01 Published 1988 Journal J. Reprod. Fertil. Section Abstract Doc Link 3184045 Disease Relevance 0.06 Pain Relevance 0.06
Electrical field stimulation (EFS, 10 V, 50 mA/cm2, 5-50 Hz, 1 ms pulse duration, 10 s train every 20 s for 5 min) produced a rapid and reproducible outflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) from superfused slices from the dorsal half of the rat spinal cord which is abolished by tetrodotoxin (TTX, 0.3 microM), in vitro capsaicin desensitization (10 microM for 30 min) and in Ca-free medium.
Gene_expression (produced) of like-immunoreactivity in dorsal associated with tetrodotoxin, qutenza, spinal cord and calcitonin gene-related peptide
15) Confidence 0.01 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1322515 Disease Relevance 0 Pain Relevance 0.63
In previous studies, we reported that supraspinally administered DAMGO, a mu-opioid agonist, produces a dose-related, naloxone-reversible inhibition of formalin-evoked pain behaviors and spinal cord Fos-like immunoreactivity (FLI) in the rat spinal cord.
Gene_expression (produces) of immunoreactivity in spinal cord associated with pain, mu agonist, narcan and spinal cord
16) Confidence 0.01 Published 1996 Journal Pain Section Abstract Doc Link 8826484 Disease Relevance 0.17 Pain Relevance 1.06
We examined the effects of butalbital (30, 100, and 1000 micrograms/kg) on the number of cells expressing c-fos-like immunoreactivity (c-fos-LI), a marker of neuronal activation, within lamina I, IIo of the trigeminal nucleus caudalis and the nucleus of the solitary tract 2 hours after the intracisternal injection of capsaicin (0.1 mL; 15.25 mg/mL) or vehicle in urethane-anesthetized guinea pigs (N = 45).
Gene_expression (expressing) of immunoreactivity in neuronal associated with qutenza
17) Confidence 0.01 Published 1999 Journal Headache Section Abstract Doc Link 11279945 Disease Relevance 0 Pain Relevance 0.24
As reported previously, ENSLI cells from untreated chick retinas showed a cyclical pattern of immunoreactivity, with increased immunoreactivity in the light compared to the dark.
Gene_expression (pattern) of immunoreactivity in retinas
18) Confidence 0.00 Published 1997 Journal Vis. Neurosci. Section Abstract Doc Link 9364719 Disease Relevance 0.56 Pain Relevance 0.89
Vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) and neuropeptide Y (NPY)-LI was detected in a large number of varicose nerve fibres in the paraganglia.
Gene_expression (detected) of immunoreactivity in nerve associated with neuropeptide
19) Confidence 0.00 Published 1989 Journal Acta Otolaryngol. Section Abstract Doc Link 2648751 Disease Relevance 0.18 Pain Relevance 0.42
Continuous electric stimulation of the pelvic nerve at 4 Hz or intermittent electric burst stimulation of the pelvic nerve at 40 Hz during 1 second with 10-second rest periods produced a marked release of NKA-like immunoreactivity (NKA-LI) and SP-LI from the colon to blood (P less than 0.001).
Gene_expression (produced) of immunoreactivity in nerve associated with substance p
20) Confidence 0.00 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1702076 Disease Relevance 0.08 Pain Relevance 0.26

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