INT61495

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.19
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ICA1) Golgi apparatus (ICA1) nucleolus (ICA1)
nucleus (ICA1) molecular_function (ICA1) cytoplasm (ICA1)
Anatomy Link Frequency
external carotid 2
fibroblasts 1
connective tissue 1
stage 4 1
ICA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 52 99.96 Very High Very High Very High
alcohol 15 98.88 Very High Very High Very High
headache 22 98.76 Very High Very High Very High
Dismenorea 1 97.94 Very High Very High Very High
Migraine 20 91.84 High High
cva 7 83.08 Quite High
depression 1 67.36 Quite High
imagery 3 58.84 Quite High
beta blocker 6 13.44 Low Low
Neuropeptide 1 12.80 Low Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 20 98.84 Very High Very High Very High
Headache 13 98.76 Very High Very High Very High
Dysmenorrhea 1 97.94 Very High Very High Very High
Convulsion 72 95.88 Very High Very High Very High
Migraine Disorders 19 91.84 High High
Pathologic Constriction 15 89.84 High High
Stroke 8 89.44 High High
Hypersensitivity 1 87.44 High High
Increased Venous Pressure Under Development 12 86.72 High High
Dizziness 1 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male N5F2 P69–P164 Scn9a knockin littermate mice were stimulated twice daily with a subthreshold 3mA corneal stimulation for 3 seconds until they reached a stably kindled state, defined as four consecutive secondarily generalized seizures (Racine stage 4–5) [35].
Positive_regulation (stimulated) of P69 in stage 4 associated with convulsion
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.44 Pain Relevance 0
Using 3T MRA, we measured: (i) blood flow in the basilar (BA) and internal carotid arteries (ICA) and (ii) diameters of the middle meningeal, external carotid, ICA, middle cerebral, BA and posterior cerebral arteries at three timepoints: (a) at baseline, outside an attack; (b) during infusion of NTG or placebo and (c) during a provoked attack or, if no attack had occurred, at 6 h after infusion.
Positive_regulation (carotid) of ICA in external carotid
2) Confidence 0.41 Published 2008 Journal Brain Section Abstract Doc Link 18502781 Disease Relevance 0.83 Pain Relevance 0.77
Using 3T MRA, we measured: (i) blood flow in the basilar (BA) and internal carotid arteries (ICA) and (ii) diameters of the middle meningeal, external carotid, ICA, middle cerebral, BA and posterior cerebral arteries at three timepoints: (a) at baseline, outside an attack; (b) during infusion of NTG or placebo and (c) during a provoked attack or, if no attack had occurred, at 6 h after infusion.
Positive_regulation (carotid) of ICA in external carotid
3) Confidence 0.41 Published 2008 Journal Brain Section Abstract Doc Link 18502781 Disease Relevance 0.77 Pain Relevance 0.70
The cause of this bilateral segmental ICA and BA absence may be maldevelopment of vessel connective tissue or extracellular matrix.


Positive_regulation (cause) of ICA in connective tissue
4) Confidence 0.34 Published 2006 Journal Surg Neurol Section Body Doc Link 16720187 Disease Relevance 0 Pain Relevance 0
We found that both time to peak and time-constant of inactivation of ICa,TTX were slower than that of INa.
Positive_regulation (constant) of ICa associated with tetrodotoxin
5) Confidence 0.10 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87
In 30 patients (6 women, 24 men; mean age 63.1±11.3 years; age range 35–86 years) who had undergone ICA for evaluation of suspected CAD, CT coronary angiography was performed within 30 days of catheterization (mean 14±9 days).
Positive_regulation (undergone) of ICA associated with coronary artery disease
6) Confidence 0.09 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1705545 Disease Relevance 0.50 Pain Relevance 0.03
In addition, INa.TTXR in cardiac fibroblasts, as NaV1.5-encoded INa.TTXR in gastric epithelial cells [39], was inhibited by high concentrations of the ICa.L blocker nifedipine (Fig. 6).
Positive_regulation (concentrations) of ICa in fibroblasts
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.30
Premenstrual tension-headache (PTH) and its exacerbation by alcohol in women is also accompanied by deficits in IMg2+, and elevation in serum ICa2+/IMg2+; IV MgSO4 corrects the PTH and the serum deficit in IMg2+.
Positive_regulation (elevation) of ICa2 associated with dismenorea, headache and alcohol
8) Confidence 0.01 Published 1999 Journal Alcohol Section Abstract Doc Link 10548155 Disease Relevance 1.66 Pain Relevance 1.20

General Comments

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