INT61495

Context Info Confidence 0.49 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 4.19 Pain Relevance 3.87

cytosol (ICA1) Golgi apparatus (ICA1) nucleolus (ICA1) nucleus (ICA1) molecular_function (ICA1) cytoplasm (ICA1)

Anatomy Link Frequency external carotid 2 fibroblasts 1 connective tissue 1 stage 4 1 ICA1 (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 52 99.96 alcohol 15 98.88 headache 22 98.76 Dismenorea 1 97.94 Migraine 20 91.84 cva 7 83.08 depression 1 67.36 imagery 3 58.84 beta blocker 6 13.44 Neuropeptide 1 12.80

Disease Link Frequency Relevance Heat Coronary Artery Disease 20 98.84 Headache 13 98.76 Dysmenorrhea 1 97.94 Convulsion 72 95.88 Migraine Disorders 19 91.84 Pathologic Constriction 15 89.84 Stroke 8 89.44 Hypersensitivity 1 87.44 Increased Venous Pressure Under Development 12 86.72 Dizziness 1 86.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Male N5F2 P69–P164 Scn9a knockin littermate mice were stimulated twice daily with a subthreshold 3mA corneal stimulation for 3 seconds until they reached a stably kindled state, defined as four consecutive secondarily generalized seizures (Racine stage 4–5) [35].

Positive_regulation (stimulated) of P69 in stage 4 associated with convulsion

1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.44 Pain Relevance 0

Using 3T MRA, we measured: (i) blood flow in the basilar (BA) and internal carotid arteries (ICA) and (ii) diameters of the middle meningeal, external carotid, ICA, middle cerebral, BA and posterior cerebral arteries at three timepoints: (a) at baseline, outside an attack; (b) during infusion of NTG or placebo and (c) during a provoked attack or, if no attack had occurred, at 6 h after infusion.

Positive_regulation (carotid) of ICA in external carotid

2) Confidence 0.41 Published 2008 Journal Brain Section Abstract Doc Link 18502781 Disease Relevance 0.83 Pain Relevance 0.77

Using 3T MRA, we measured: (i) blood flow in the basilar (BA) and internal carotid arteries (ICA) and (ii) diameters of the middle meningeal, external carotid, ICA, middle cerebral, BA and posterior cerebral arteries at three timepoints: (a) at baseline, outside an attack; (b) during infusion of NTG or placebo and (c) during a provoked attack or, if no attack had occurred, at 6 h after infusion.

Positive_regulation (carotid) of ICA in external carotid

3) Confidence 0.41 Published 2008 Journal Brain Section Abstract Doc Link 18502781 Disease Relevance 0.77 Pain Relevance 0.70

The cause of this bilateral segmental ICA and BA absence may be maldevelopment of vessel connective tissue or extracellular matrix.

Positive_regulation (cause) of ICA in connective tissue

4) Confidence 0.34 Published 2006 Journal Surg Neurol Section Body Doc Link 16720187 Disease Relevance 0 Pain Relevance 0

We found that both time to peak and time-constant of inactivation of ICa,TTX were slower than that of INa.

Positive_regulation (constant) of ICa associated with tetrodotoxin

5) Confidence 0.10 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87

In 30 patients (6 women, 24 men; mean age 63.1±11.3 years; age range 35–86 years) who had undergone ICA for evaluation of suspected CAD, CT coronary angiography was performed within 30 days of catheterization (mean 14±9 days).

Positive_regulation (undergone) of ICA associated with coronary artery disease

6) Confidence 0.09 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1705545 Disease Relevance 0.50 Pain Relevance 0.03

In addition, INa.TTXR in cardiac fibroblasts, as NaV1.5-encoded INa.TTXR in gastric epithelial cells [39], was inhibited by high concentrations of the ICa.L blocker nifedipine (Fig. 6).

Positive_regulation (concentrations) of ICa in fibroblasts

7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.30

Premenstrual tension-headache (PTH) and its exacerbation by alcohol in women is also accompanied by deficits in IMg2+, and elevation in serum ICa2+/IMg2+; IV MgSO4 corrects the PTH and the serum deficit in IMg2+.

Positive_regulation (elevation) of ICa2 associated with dismenorea, headache and alcohol

8) Confidence 0.01 Published 1999 Journal Alcohol Section Abstract Doc Link 10548155 Disease Relevance 1.66 Pain Relevance 1.20

General Comments

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