INT6150

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Context Info
Confidence 0.68
First Reported 1986
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 4.06
Pain Relevance 16.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
dorsal 4
ganglion cells 4
nerve 4
corpus 3
dura mater 3
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 113 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
opioid receptor 14 100.00 Very High Very High Very High
agonist 7 100.00 Very High Very High Very High
Bile 4 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
qutenza 75 99.98 Very High Very High Very High
tetrodotoxin 8 99.98 Very High Very High Very High
primary afferent fibers 1 99.98 Very High Very High Very High
Dorsal horn 12 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 100.00 Very High Very High Very High
Meningitis 4 99.98 Very High Very High Very High
Headache 11 98.92 Very High Very High Very High
Dislocations 1 97.60 Very High Very High Very High
Hypertension 5 94.80 High High
Intracranial Hypertension 2 92.28 High High
Bacterial Meningitis 8 88.56 High High
Pneumococcal Meningitis 4 84.88 Quite High
Nociception 5 80.56 Quite High
INFLAMMATION 9 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCl and veratridine also increased CGRP-LI in dialysates during the first posttreatment period, while tetrodotoxin induced a significant but delayed decrease in CGRP-LI levels.
Positive_regulation (induced) of Negative_regulation (decrease) of CGRP associated with tetrodotoxin and calcitonin gene-related peptide
1) Confidence 0.68 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8933370 Disease Relevance 0.10 Pain Relevance 0.77
Meningitis caused a depletion of calcitonin gene-related peptide (CGRP) and substance P from meningeal nerve fibers, which was prevented by zolmitriptan and naratriptan.
Positive_regulation (caused) of Negative_regulation (depletion) of gene-related peptide in nerve associated with meningitis, substance p and calcitonin gene-related peptide
2) Confidence 0.60 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172384 Disease Relevance 1.08 Pain Relevance 0.88
Meningitis caused a depletion of calcitonin gene-related peptide (CGRP) and substance P from meningeal nerve fibers, which was prevented by zolmitriptan and naratriptan.
Positive_regulation (caused) of Negative_regulation (depletion) of CGRP in nerve associated with meningitis, substance p and calcitonin gene-related peptide
3) Confidence 0.50 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172384 Disease Relevance 1.08 Pain Relevance 0.88
Unilateral genitofemoral nerve section induced a loss of CGRP- or tachykinin- and an increase of galanin-immunoreactive cells in the ipsilateral L1/L2 ganglia.
Positive_regulation (induced) of Negative_regulation (loss) of CGRP in ganglia
4) Confidence 0.50 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.15 Pain Relevance 0.23
Capsaicin induced a loss of CGRP- and tachykinin-immunoreactive ganglion cells and of CGRP, tachykinin or galanin immunoreactivity from the dorsal horn.
Positive_regulation (induced) of Negative_regulation (loss) of CGRP in ganglion cells associated with ganglion cysts, qutenza and dorsal horn
5) Confidence 0.50 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.16 Pain Relevance 0.26
Capsaicin induced a loss of CGRP- and tachykinin-immunoreactive ganglion cells and of CGRP, tachykinin or galanin immunoreactivity from the dorsal horn.
Positive_regulation (induced) of Negative_regulation (loss) of CGRP in ganglion cells associated with ganglion cysts, qutenza and dorsal horn
6) Confidence 0.50 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.16 Pain Relevance 0.26
Electrical field stimulation (EFS, 10 V, 50 mA/cm2, 5-50 Hz, 1 ms pulse duration, 10 s train every 20 s for 5 min) produced a rapid and reproducible outflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) from superfused slices from the dorsal half of the rat spinal cord which is abolished by tetrodotoxin (TTX, 0.3 microM), in vitro capsaicin desensitization (10 microM for 30 min) and in Ca-free medium.
Positive_regulation (produced) of Negative_regulation (outflow) of CGRP in dorsal associated with tetrodotoxin, qutenza, spinal cord and calcitonin gene-related peptide
7) Confidence 0.49 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1322515 Disease Relevance 0 Pain Relevance 0.63
On landing, flight animals had increased ionized calcium (P < 0.001), elevated parathyroid hormone levels (P < 0.001), reduced calcitonin levels (P < 0.05), unchanged 1,25(OH)(2)D(3) levels, and elevated skull (P < 0.01) and reduced femur bone mineral density.
Positive_regulation (increased) of Negative_regulation (reduced) of calcitonin in femur
8) Confidence 0.47 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11744636 Disease Relevance 0.09 Pain Relevance 0.07
These results suggest that activity in a specific population of primary afferent fibers causes a dramatic depletion of CGRP in the dorsal horn.
Positive_regulation (causes) of Negative_regulation (depletion) of CGRP in dorsal horn associated with primary afferent fibers, dorsal horn and calcitonin gene-related peptide
9) Confidence 0.47 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2234494 Disease Relevance 0 Pain Relevance 0.76
Capsaicin induces a depletion of calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the cardiovascular system of the guinea pig and rat.
Positive_regulation (induces) of Negative_regulation (depletion) of calcitonin gene-related peptide in cardiovascular system associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.47 Published 1986 Journal J. Auton. Nerv. Syst. Section Title Doc Link 2427561 Disease Relevance 0 Pain Relevance 0.80
Pre-exposure of tissues to capsaicin (0.1-1.0 mumol/l, 5 min contact time) caused a dose-dependent reduction of the amount of CGRP-IR which was released by a second exposure to capsaicin.
Positive_regulation (caused) of Negative_regulation (reduction) of CGRP-IR associated with qutenza
11) Confidence 0.47 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2096299 Disease Relevance 0 Pain Relevance 1.04
Capsaicin pretreatment caused a depletion of calcitonin gene-related peptide by at least 98% compared with that in vehicle-pretreated rats.
Positive_regulation (caused) of Negative_regulation (depletion) of calcitonin associated with qutenza and calcitonin gene-related peptide
12) Confidence 0.46 Published 1994 Journal Hepatology Section Abstract Doc Link 7982662 Disease Relevance 0.42 Pain Relevance 0.85
Given that 4991W93 is inactive clinically at non-vascular doses, it seems clear that the 5HT(1B/1D) agonist effects of the compound are necessary for blockade of CGRP release and thus any anti-migraine action.
Positive_regulation (necessary) of Negative_regulation (blockade) of CGRP associated with migraine, agonist, 5ht and calcitonin gene-related peptide
13) Confidence 0.46 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11249961 Disease Relevance 0.16 Pain Relevance 0.96
Electrical field stimulation (EFS, 10 V, 50 mA/cm2, 5-50 Hz, 1 ms pulse duration, 10 s train every 20 s for 5 min) produced a rapid and reproducible outflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) from superfused slices from the dorsal half of the rat spinal cord which is abolished by tetrodotoxin (TTX, 0.3 microM), in vitro capsaicin desensitization (10 microM for 30 min) and in Ca-free medium.
Positive_regulation (produced) of Negative_regulation (outflow) of calcitonin in dorsal associated with tetrodotoxin, qutenza, spinal cord and calcitonin gene-related peptide
14) Confidence 0.46 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1322515 Disease Relevance 0 Pain Relevance 0.61
Pretreatment with the selective sensory neurotoxin capsaicin induced a gastric CGRP-li decrease in the corpus and forestomach.
Positive_regulation (induced) of Negative_regulation (decrease) of CGRP in corpus associated with qutenza
15) Confidence 0.44 Published 1993 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 8303215 Disease Relevance 0 Pain Relevance 0.35
One minute of such stimulation was sufficient to remove CGRP from most of the terminals.
Positive_regulation (sufficient) of Negative_regulation (remove) of CGRP associated with calcitonin gene-related peptide
16) Confidence 0.43 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.72
Another group of animals was given the neurotoxin capsaicin which causes a depletion of SP and CGRP from sensory axons.
Positive_regulation (causes) of Negative_regulation (depletion) of CGRP associated with qutenza, calcitonin gene-related peptide and substance p
17) Confidence 0.41 Published 1991 Journal Exp. Neurol. Section Abstract Doc Link 1710573 Disease Relevance 0.07 Pain Relevance 0.87
The inhibitory action of central CGRP (i. c.v.) on pancreatic secretion and CCK release stimulated by bile-pancreatic juice diversion is partially mediated by an alpha-adrenergic mechanism, although its precise mechanism has not been elucidated.
Spec (partially) Positive_regulation (mediated) of Negative_regulation (action) of CGRP in bile associated with bile and cholecystokinin
18) Confidence 0.40 Published 2000 Journal Jpn. J. Physiol. Section Abstract Doc Link 10880881 Disease Relevance 0 Pain Relevance 0.47
Using pharmacological tools, we demonstrated that this effect of CGRP was dependent on protein kinase A and PKC activation and was prevented by the trafficking inhibitor brefeldin A.
Positive_regulation (dependent) of Negative_regulation (effect) of CGRP associated with calcitonin gene-related peptide
19) Confidence 0.37 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16763024 Disease Relevance 0.26 Pain Relevance 0.94
Pretreatment with capsaicin caused a depletion of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI) from the trigeminal ganglion, dura mater and cerebral arteries.
Spec (like) Positive_regulation (caused) of Negative_regulation (depletion) of gene-related peptide in dura mater associated with ganglion cysts, qutenza, trigeminal ganglion, calcitonin gene-related peptide and substance p
20) Confidence 0.17 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1708899 Disease Relevance 0.10 Pain Relevance 0.83

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