INT61500

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 27.33
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
plasma 3
cartilage 2
extracellular matrix 2
stroma 1
tube 1
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 104 99.76 Very High Very High Very High
IPN 8 99.42 Very High Very High Very High
melanocortin 1 receptor 15 99.40 Very High Very High Very High
rheumatoid arthritis 296 99.04 Very High Very High Very High
Sciatic nerve 4 98.80 Very High Very High Very High
metalloproteinase 156 97.56 Very High Very High Very High
cytokine 124 92.08 High High
antagonist 12 88.88 High High
vincristine 12 83.32 Quite High
cINOD 6 80.08 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 221 100.00 Very High Very High Very High
Boutonneuse Fever 176 100.00 Very High Very High Very High
Myocardial Infarction 95 100.00 Very High Very High Very High
Cancer 512 99.88 Very High Very High Very High
Osteoarthritis 61 99.76 Very High Very High Very High
Breast Cancer 191 99.74 Very High Very High Very High
Adhesions 470 99.32 Very High Very High Very High
Pheochromocytoma 69 99.28 Very High Very High Very High
Rheumatoid Arthritis 308 99.04 Very High Very High Very High
Leptospirosis 203 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: HSA-coating markedly reduced the binding of fibronectin on tube surfaces in vitro.
fibronectin Binding (binding) of in tube
1) Confidence 0.48 Published 2001 Journal Int. J. Pediatr. Otorhinolaryngol. Section Body Doc Link 11278018 Disease Relevance 0.16 Pain Relevance 0
Indeed, MSF is more quickly recognized and treated with more effective antimicrobial drugs than in the past.
MSF Binding (recognized) of associated with boutonneuse fever
2) Confidence 0.40 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.26 Pain Relevance 0
Thus alterations in the structure of cartilage fibronectin do not appear to correlate with the increased level of fibronectin protein associated with osteoarthritis.
fibronectin Binding (associated) of in cartilage associated with osteoarthritis
3) Confidence 0.35 Published 1995 Journal Osteoarthr. Cartil. Section Abstract Doc Link 8581748 Disease Relevance 0.75 Pain Relevance 0.14
This may explain why transcriptomic analysis of blood cells performed in the present study failed to readily detect FN1 expression and a potential association with clinical outcome of MI patients (i.e., FN1 is not differentially expressed by HF and non-HF patients).
FN1 Binding (association) of in blood cells associated with myocardial infarction
4) Confidence 0.34 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.59 Pain Relevance 0.07
We synthesized gelatin-based, interpenetrating network (IPN) scaffolds immobilized with fibronectin (FN)-derived peptides to assess monocyte-biomaterial interaction.
fibronectin Binding (interaction) of in monocyte associated with ipn
5) Confidence 0.33 Published 2007 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 17623553 Disease Relevance 0.07 Pain Relevance 0.35
The first hypothesis could be that severe forms of MSF were not well recognized in the past.
MSF Binding (recognized) of associated with boutonneuse fever
6) Confidence 0.30 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.47 Pain Relevance 0
Careful watching to determine whether B. cereus resistant to carbapem increases may be also important for empiric therapy, because carbapenem is often selected as the initial therapy for FN in patients with severe neutropenia.
FN Binding (therapy) of associated with neutropenia
7) Confidence 0.28 Published 2008 Journal J. Infect. Chemother. Section Abstract Doc Link 18936889 Disease Relevance 1.13 Pain Relevance 0.10
In addition, binding to fibronectin was significantly reduced by alphaMSH in the wild type transfectants whereas this was not observed in the variant transfected clones; binding to laminin was not affected by alphaMSH in this cell line.
fibronectin Binding (binding) of
8) Confidence 0.17 Published 2002 Journal Oncogene Section Abstract Doc Link 12439754 Disease Relevance 0.79 Pain Relevance 1.01
The authors attributed these profound results to two factors: the enhanced surface hydrophilicity enabling cell spreading, and the opportunity for fibronectin to bind to the PNaSS, increasing the number of focal adhesion contacts and the potential for organized cytoskeletal formation.
fibronectin Binding (bind) of associated with adhesions
9) Confidence 0.16 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.27 Pain Relevance 0
Ma-HCl, (S)-(-)-[6-[4-(Morpholinoformimidoyl)benzamido]-3,4-dihydro-2H-1-b enzopyran-3-yl]acetic acid hydrochloride, the hydrochloride salt of Ma (active metabolite), inhibited the binding of fibrinogen to immobilized human glycoprotein IIb/III receptor with an IC50 value of 0.12+/-0.03 nM without affecting binding to either fibronectin or vitronectin receptors.
fibronectin Binding (binding) of
10) Confidence 0.16 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10079002 Disease Relevance 0.21 Pain Relevance 0.11
Combinations of fibronectin, VEGF and purified G3 were tested.
fibronectin Binding (Combinations) of
11) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.73 Pain Relevance 0
Combinations of fibronectin, VEGF and purified G3 were tested.
fibronectin Binding (Combinations) of
12) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.47 Pain Relevance 0.05
Fibronectin also binds VEGF and regulates endothelial cell activities [44].
Fibronectin Binding (binds) of in endothelial cell
13) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.39 Pain Relevance 0.05
The interactions between tumor cells, surrounding stromal components and neo-vascularization in breast cancer may include interactions with VEGF and fibronectin.
fibronectin Binding (interactions) of associated with cancer and breast cancer
14) Confidence 0.12 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206723 Disease Relevance 1.06 Pain Relevance 0
Adrenomedullin increased RA-FLSs adhesion to the ECM proteins vitronectin, fibronectin, and Coll.I, which are abundant in the rheumatoid pannus.
fibronectin Binding (abundant) of associated with rheumatoid arthritis and adhesions
15) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.86 Pain Relevance 0.36
Gene filter data from two patients also showed similar pattern of collagen, type 1 (alpha 2), fibronectin 1, MMP-1, TGF-?
fibronectin 1 Binding (pattern) of
16) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.69 Pain Relevance 0.03
As age >65 years is consistently shown to be associated with increased FN risk, G-CSF prophylaxis should be considered for supporting chemotherapy delivery in all elderly patients receiving myelotoxic chemotherapy [30].
FN Binding (associated) of associated with neutropenia
17) Confidence 0.08 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 1.21 Pain Relevance 0.03
Recent data from a large US survey (41,779 patients with FN treated at 115 medical centres) have highlighted the mortality risk associated with FN.
FN Binding (associated) of associated with neutropenia
18) Confidence 0.08 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.47 Pain Relevance 0.04
Considering that tumor cell interactions with Fn are important for the development of secondary tumors inside the bone marrow stroma [34], substrates were uniformly coated with Fn to better simulate the bone microenvironment and control the surface chemistry.
Fn Binding (interactions) of in stroma associated with cancer and metastasis
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.96 Pain Relevance 0
Furthermore all type 2C mutants showed decreased fibronectin binding which is required for extracellular matrix formation. pVHL fulfills this function by direct binding to fibronectin.'
fibronectin Binding (binding) of in extracellular matrix
20) Confidence 0.07 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2169240 Disease Relevance 1.23 Pain Relevance 0

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