INT6151

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.86
Pain Relevance 11.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 4
neurons 4
spinal 2
dorsal 2
outflow 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 258 100.00 Very High Very High Very High
Glutamate 68 100.00 Very High Very High Very High
Spinal cord 45 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
qutenza 70 99.84 Very High Very High Very High
tetrodotoxin 2 99.84 Very High Very High Very High
guanethidine 3 99.24 Very High Very High Very High
nMDA receptor antagonist 12 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 11 99.84 Very High Very High Very High
Diabetes Mellitus 6 99.24 Very High Very High Very High
Nociception 36 99.16 Very High Very High Very High
Stress 9 95.72 Very High Very High Very High
Pain 122 94.08 High High
Neuropathic Pain 10 90.64 High High
Diabetic Neuropathy 2 84.56 Quite High
Injury 20 84.36 Quite High
Ganglion Cysts 48 81.64 Quite High
Headache 24 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with AM-251 also reduced the depletion of CGRP, suppressed Fos-induction, and prevented the increase in capsaicin-evoked spinal CGRP release.
Negative_regulation (reduced) of Negative_regulation (depletion) of CGRP in spinal associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16935424 Disease Relevance 0.41 Pain Relevance 2.03
Depletions of nerve growth factor, substance P and CGRP in sciatic nerves of diabetic rats were prevented by CB1093, which also increased soleus nerve growth factor concentrations to 30 % over those seen in non-diabetic rats and increased its mRNA expression in skin.
Negative_regulation (prevented) of Negative_regulation (Depletions) of CGRP in nerve
2) Confidence 0.57 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
Reduction in CGRP content was prevented by TGF alpha pretreatment.
Negative_regulation (prevented) of Negative_regulation (Reduction) of CGRP associated with calcitonin gene-related peptide
3) Confidence 0.44 Published 2003 Journal Life Sci. Section Abstract Doc Link 12586218 Disease Relevance 0.72 Pain Relevance 0.67
Guanethidine treatment of capsaicin-injected rats reversed the loss of calcitonin gene-related peptide-immunoreactive nerves, but not that of substance P-immunoreactive neurons.
Negative_regulation (reversed) of Negative_regulation (loss) of calcitonin in neurons associated with qutenza, guanethidine, substance p and calcitonin gene-related peptide
4) Confidence 0.43 Published 1992 Journal Cell Tissue Res. Section Abstract Doc Link 1378354 Disease Relevance 0 Pain Relevance 1.13
The decrease in survival after CGRP-receptor block was significant in one of two tests.
Negative_regulation (decrease) of Negative_regulation (block) of CGRP
5) Confidence 0.43 Published 1999 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 10088510 Disease Relevance 0 Pain Relevance 0.28
Serotonergic inhibition of both CGRP and glutamate release can be blocked by pertussis toxin and NAS-181, a 5-HT1B/1D antagonist.
Negative_regulation (blocked) of Negative_regulation (inhibition) of CGRP associated with glutamate, bordatella infection and antagonist
6) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2359740 Disease Relevance 0.60 Pain Relevance 1.23
Electrical field stimulation (EFS, 10 V, 50 mA/cm2, 5-50 Hz, 1 ms pulse duration, 10 s train every 20 s for 5 min) produced a rapid and reproducible outflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) from superfused slices from the dorsal half of the rat spinal cord which is abolished by tetrodotoxin (TTX, 0.3 microM), in vitro capsaicin desensitization (10 microM for 30 min) and in Ca-free medium.
Negative_regulation (abolished) of in outflow Negative_regulation (outflow) of CGRP in dorsal associated with tetrodotoxin, qutenza, spinal cord and calcitonin gene-related peptide
7) Confidence 0.41 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1322515 Disease Relevance 0 Pain Relevance 0.72
Inhibition of PKA, but not PKC, blocks CGRP-induced synaptic facilitation
Negative_regulation (Inhibition) of Negative_regulation (blocks) of CGRP associated with calcitonin gene-related peptide
8) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.09 Pain Relevance 0.81
Electrical field stimulation (EFS, 10 V, 50 mA/cm2, 5-50 Hz, 1 ms pulse duration, 10 s train every 20 s for 5 min) produced a rapid and reproducible outflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) from superfused slices from the dorsal half of the rat spinal cord which is abolished by tetrodotoxin (TTX, 0.3 microM), in vitro capsaicin desensitization (10 microM for 30 min) and in Ca-free medium.
Negative_regulation (abolished) of in outflow Negative_regulation (outflow) of calcitonin in dorsal associated with tetrodotoxin, qutenza, spinal cord and calcitonin gene-related peptide
9) Confidence 0.39 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1322515 Disease Relevance 0 Pain Relevance 0.72
A PKA, but not PKC, inhibitor reversed the electrophysiological and behavioral effects of CGRP, and in the presence of an NMDA receptor antagonist CGRP had no effect.
Negative_regulation (reversed) of Negative_regulation (effects) of CGRP associated with nmda receptor antagonist and calcitonin gene-related peptide
10) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.89 Pain Relevance 1.36
Intravesical capsaicin or RTX decreased, in a similar way, the number of CGRP and SP-IR (immunoreactive) fibers coursing in the muscular layer and the mucosa.
Negative_regulation (decreased) of Negative_regulation (number) of CGRP associated with qutenza
11) Confidence 0.34 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11269923 Disease Relevance 0.12 Pain Relevance 0.70
Further, it prevented the induced reduction in levels of the neuropeptides substance P and calcitonin gene related peptide measured from cervical dorsal root ganglia.
Negative_regulation (prevented) of Negative_regulation (reduction) of calcitonin gene in dorsal root ganglia associated with calcitonin gene related peptide, neuropeptide and substance p
12) Confidence 0.12 Published 1994 Journal Brain Res. Section Abstract Doc Link 7512429 Disease Relevance 0.74 Pain Relevance 0.65
Consistent with the loss of TRPV1 expressing central nerve terminals, the immunoreactivity of CGRP and SP associated with TRPV1 immunoreactivity was also significantly reduced (p<0.001) (Fig. 6E, F).
Negative_regulation (reduced) of Negative_regulation (immunoreactivity) of CGRP in nerve
13) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.68 Pain Relevance 0.55
Thus, decreased levels of CGRP are likely to reduce the stimulatory effects of glutamate, substance P, and ATP on second order neurons that promote nociception [25,47].
Spec (likely) Negative_regulation (reduce) of Negative_regulation (decreased) of CGRP in neurons associated with nociception, glutamate, substance p and calcitonin gene-related peptide
14) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.61 Pain Relevance 0.95

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