INT61512

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Context Info
Confidence 0.05
First Reported 1995
Last Reported 1999
Negated 0
Speculated 1
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 0.89
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GHR) extracellular space (GHR) extracellular region (GHR)
plasma membrane (GHR) nucleus (GHR) cytoplasm (GHR)
GHR (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 28 100.00 Very High Very High Very High
neuralgia 4 99.76 Very High Very High Very High
Trigeminal neuralgia 2 94.84 High High
antidepressant 2 51.00 Quite High
Analgesic 1 44.24 Quite Low
Disease Link Frequency Relevance Heat
Cancer 8 100.00 Very High Very High Very High
Epilepsy 2 95.32 Very High Very High Very High
Headache 2 94.84 High High
Aging 2 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period.
Spec (whether) Regulation (influences) of carbamazepine-serum protein Binding (binding) of associated with epilepsy, trigeminal neuralgia and carbamazepine
1) Confidence 0.05 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10528982 Disease Relevance 0.19 Pain Relevance 0.39
Age-related alteration of carbamazepine-serum protein binding in man.
Regulation (alteration) of carbamazepine-serum protein Binding (binding) of associated with neuralgia and carbamazepine
2) Confidence 0.05 Published 1999 Journal J. Pharm. Pharmacol. Section Title Doc Link 10528982 Disease Relevance 0.23 Pain Relevance 0.69
Differential effect of cancer on the serum protein binding to mianserin and imipramine.
Regulation (effect) of serum protein Binding (binding) of associated with cancer
3) Confidence 0.01 Published 1995 Journal Eur J Drug Metab Pharmacokinet Section Title Doc Link 8582434 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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