INT61519

Context Info Confidence 0.78 First Reported 1995 Last Reported 2011 Negated 1 Speculated 5 Reported most in Abstract Documents 112 Total Number 118 Disease Relevance 89.29 Pain Relevance 18.22

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo) lysosome (Mpo)

Anatomy Link Frequency neutrophil 21 kidney 10 lungs 8 liver 6 Plasma 4 Mpo (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 31 99.48 Ultiva 16 99.14 methotrexate 9 98.88 Paracetamol 107 98.32 Calcitonin gene-related peptide 14 98.32 Morphine 408 98.22 Leflunomide 8 97.92 ischemia 163 97.72 Inflammation 2063 97.64 Inflammatory response 477 97.44

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1057 100.00 Disease 696 100.00 Infection 719 99.96 Targeted Disruption 550 99.96 Myocardial Infarction 348 99.96 Burns 527 99.52 Sprains And Strains 537 99.40 Coronary Artery Disease 36 99.40 Injury 1675 99.28 Melioidosis 171 98.14

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Myeloperoxidase is primarily found in neutrophils, and levels of myeloperoxidase in tissues reflect neutrophil sequestration.

Gene_expression (found) of Myeloperoxidase in neutrophil

1) Confidence 0.78 Published 1995 Journal J Burn Care Rehabil Section Abstract Doc Link 8582922 Disease Relevance 0.69 Pain Relevance 0.05

There was a trend toward higher MPO levels in the kidney following renal I/R.

Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy

2) Confidence 0.77 Published 2010 Journal APMIS Section Abstract Doc Link 20132173 Disease Relevance 1.34 Pain Relevance 0.32

After vascular perfusion, lungs were analyzed for their levels of EB dye and myeloperoxidase (MPO).

Spec (analyzed) Gene_expression (levels) of MPO in lungs associated with urological neuroanatomy

3) Confidence 0.77 Published 2009 Journal Toxicology Mechanisms and Methods Section Abstract Doc Link PMC2736052 Disease Relevance 1.90 Pain Relevance 0.12

This study is to explore the effect of remifentanil on inducible nitric oxide synthase (iNOS) expression, IL-6 and IL-10 levels, myeloperoxidase (MPO) activity, white blood cell count in bronchoalveolar (BALF), ALT and AST activity in septic mice.

Gene_expression (expression) of MPO in white blood cell associated with urological neuroanatomy and ultiva

4) Confidence 0.76 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.17 Pain Relevance 0.34

Blood urea nitrogen, serum creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in blood and glutathione (GSH) and malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver and kidney tissues were measured.

Gene_expression (levels) of myeloperoxidase in kidney associated with urological neuroanatomy

5) Confidence 0.74 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.30 Pain Relevance 0.74

Correspondingly, there was a trend toward a decrease in MPO levels in the lung, liver, kidney of PAF-treated endotoxemic mice.

Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy

6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.76 Pain Relevance 0.06

Myeloperoxidase levels were significantly higher only in the first phase (4 h; median and range; 537.5; 323.6-683.7 mU/ml; P < 0.01), whereas increased mean nitrate levels were detected in both phases (4 h: 19.0; 6.2-32 microM and 48 h: 13.7; 8.9-17.8 microM; P < 0.01).

Gene_expression (higher) of Myeloperoxidase

7) Confidence 0.67 Published 1999 Journal Peptides Section Abstract Doc Link 10503773 Disease Relevance 0.32 Pain Relevance 0.29

After vascular perfusion, lungs were analyzed for their levels of EB dye and myeloperoxidase (MPO).

Spec (analyzed) Gene_expression (levels) of myeloperoxidase in lungs associated with urological neuroanatomy

8) Confidence 0.67 Published 2009 Journal Toxicology Mechanisms and Methods Section Abstract Doc Link PMC2736052 Disease Relevance 1.89 Pain Relevance 0.12

To further quantify the degree of neutrophil infiltration into the peritoneal cavity, the MPO levels of both the peritoneal lavage cell pellets and supernatants were measured.

Gene_expression (levels) of MPO in peritoneal cavity associated with urological neuroanatomy

9) Confidence 0.67 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.40 Pain Relevance 0

It is interesting to note that P/I null mice demonstrated a higher MPO levels in their peritoneal lavage supernatants than the wild-type counterparts.

Gene_expression (levels) of MPO associated with urological neuroanatomy

10) Confidence 0.67 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.86 Pain Relevance 0

Subsequent secondary activation of its metabolites by myeloperoxidase (MPO) present in bone marrow results in the production of genotoxic quinines and reactive oxygen species.

Gene_expression (present) of myeloperoxidase in bone marrow associated with urological neuroanatomy

11) Confidence 0.66 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.74 Pain Relevance 0

Subsequent secondary activation of its metabolites by myeloperoxidase (MPO) present in bone marrow results in the production of genotoxic quinines and reactive oxygen species.

Gene_expression (present) of MPO in bone marrow associated with urological neuroanatomy

12) Confidence 0.66 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.73 Pain Relevance 0

This study is to explore the effect of remifentanil on inducible nitric oxide synthase (iNOS) expression, IL-6 and IL-10 levels, myeloperoxidase (MPO) activity, white blood cell count in bronchoalveolar (BALF), ALT and AST activity in septic mice.

Gene_expression (levels) of myeloperoxidase in white blood cell associated with urological neuroanatomy and ultiva

13) Confidence 0.66 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.17 Pain Relevance 0.33

CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.

Gene_expression (production) of MPO in neutrophil associated with urological neuroanatomy and calcitonin gene-related peptide

14) Confidence 0.66 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.61 Pain Relevance 1.01

Myeloperoxidase (MPO) activity A was expressed as change of optical density (?

Gene_expression (expressed) of Myeloperoxidase associated with urological neuroanatomy

15) Confidence 0.66 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.10 Pain Relevance 0

Myeloperoxidase (MPO) activity A was expressed as change of optical density (?

Gene_expression (expressed) of MPO associated with urological neuroanatomy

16) Confidence 0.66 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.10 Pain Relevance 0

Blood urea nitrogen (BUN), serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels in blood, and glutathione (GSH), malondialdehyde (MDA), oxidized protein levels and myeloperoxidase (MPO) activity in liver and kidney tissues were measured.

Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy

17) Confidence 0.64 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.40 Pain Relevance 0.68

Blood urea nitrogen (BUN), serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels in blood, and glutathione (GSH), malondialdehyde (MDA), oxidized protein levels and myeloperoxidase (MPO) activity in liver and kidney tissues were measured.

Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy

18) Confidence 0.64 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.40 Pain Relevance 0.66

Myeloperoxidase (MPO) assay

Gene_expression (assay) of MPO associated with urological neuroanatomy

19) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.35 Pain Relevance 0.15

Myeloperoxidase (MPO) assay

Gene_expression (assay) of Myeloperoxidase associated with urological neuroanatomy

20) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.35 Pain Relevance 0.15

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