INT61540

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 6.36
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
sciatic nerve 4
nerve 4
dorsal root ganglia 4
neurons 2
bladder 2
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 92 100.00 Very High Very High Very High
Peripheral nervous system 1 99.64 Very High Very High Very High
dorsal root ganglion 7 98.16 Very High Very High Very High
Sciatic nerve 11 98.08 Very High Very High Very High
Neuritis 5 96.32 Very High Very High Very High
unmyelinated 6 94.92 High High
Hyperalgesia 3 92.52 High High
nociceptor 10 90.96 High High
Acupuncture 82 86.24 High High
Demyelination 1 75.84 Quite High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 3 99.58 Very High Very High Very High
Nociception 18 98.88 Very High Very High Very High
Death 12 98.84 Very High Very High Very High
Ganglion Cysts 10 97.68 Very High Very High Very High
Diabetes Mellitus 29 97.32 Very High Very High Very High
Experimental Autoimmune Neuritis 5 97.20 Very High Very High Very High
Targeted Disruption 4 94.68 High High
Hyperalgesia 3 92.52 High High
Polycystic Ovary Syndrome 87 91.56 High High
Inflammatory Pain 4 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, direct p75NTR inhibitory antibody application decreased CGRP and p75NTR expression after wrist inflammation (p<.01).
Negative_regulation (decreased) of Gene_expression (expression) of p75NTR in wrist
1) Confidence 0.59 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.06 Pain Relevance 0
In conclusion, long-term metabolic syndrome in FR significantly decreases bladder NGF and p75(NTR) expression.
Negative_regulation (decreases) of Gene_expression (expression) of p75 in bladder associated with metabolic syndrome
2) Confidence 0.47 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.25 Pain Relevance 0.06
Axotomy reduced expression of p75NTR (messenger RNA: 52 +/- 17%, P < 0.01; immunoreactivity: 74 +/- 3%, P < 0.05).
Negative_regulation (reduced) of Gene_expression (expression) of p75NTR
3) Confidence 0.46 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336076 Disease Relevance 0 Pain Relevance 0.29
High-affinity nerve growth factor (NGF) receptor (NGFR-TrkA) expression in DRGs was significantly reduced at 4 months (P < 0.01).
Negative_regulation (reduced) of Gene_expression (expression) of NGFR-TrkA in nerve associated with nerve growth factor
4) Confidence 0.45 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.39 Pain Relevance 0.47
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of Gene_expression (expressions) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
5) Confidence 0.45 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (prevented) of Gene_expression (expressions) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
6) Confidence 0.45 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.38 Pain Relevance 0.46
We assessed CGRP and p75NTR expression in C8 dorsal root ganglia immunochemically.
Negative_regulation (assessed) of Gene_expression (expression) of p75NTR in dorsal root ganglia
7) Confidence 0.43 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.08 Pain Relevance 0
Northern blot, immunocytochemistry, and single nerve fiber immunostaining were used to determine the expression of low-affinity nerve growth factor (NGF) receptor (p75NGFR) in the peripheral nervous system of Lewis rats during the course of experimental allergic neuritis (EAN) induced with 100 micrograms of 'SP26' synthetic peptide, corresponding to residues 53-78 of bovine P2 myelin protein.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of p75NGFR in nerve associated with peripheral nervous system, nerve growth factor, experimental autoimmune neuritis and neuritis
8) Confidence 0.41 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584242 Disease Relevance 0.48 Pain Relevance 0.54
The CB1093 did not affect expression of nerve growth factor receptors (trkA and p75(NTR)) in dorsal root ganglia in control or diabetic rats, though the p75(NTR) expression was reduced by diabetes.
Negative_regulation (reduced) of Gene_expression (expression) of p75 in dorsal root ganglia
9) Confidence 0.38 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
Furthermore, intraovarian blockade of NGF and p75NTR resulted in decreased p75NTR synthesis by ovarian theca cells and restored estrous cyclicity and ovulatory capacity in EV-injected rats [10].
Negative_regulation (decreased) of Gene_expression (synthesis) of p75NTR in theca cells associated with nerve growth factor
10) Confidence 0.38 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.45 Pain Relevance 0.36
The authors studied the potential participation of p75 in the death of axotomized cholinergic cells [19], and found that the absence of p75 does not prevent septal ChAT-positive cell loss.
Negative_regulation (prevent) of Neg (absence) Gene_expression (absence) of p75 associated with death
11) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.47 Pain Relevance 0.14
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons.
Negative_regulation (define) of Gene_expression (expression) of NGF receptor in neurons associated with ganglion cysts, nociception and dorsal root ganglion
12) Confidence 0.19 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16822986 Disease Relevance 0.43 Pain Relevance 0.65

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