INT61541

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.87
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
sciatic nerve 2
dorsal root ganglia 2
motoneurons 2
neurons 1
nerve 1
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 107 100.00 Very High Very High Very High
Sciatic nerve 72 100.00 Very High Very High Very High
Inflammatory stimuli 1 99.68 Very High Very High Very High
Neuritis 5 99.08 Very High Very High Very High
projection neuron 1 95.16 Very High Very High Very High
Dorsal horn 12 94.20 High High
Peripheral nervous system 1 91.48 High High
Hippocampus 15 90.16 High High
bDMF 213 86.96 High High
nociceptor 2 86.72 High High
Disease Link Frequency Relevance Heat
Sciatic Neuropathy 32 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.96 Very High Very High Very High
INFLAMMATION 32 99.50 Very High Very High Very High
Polycystic Ovary Syndrome 87 98.00 Very High Very High Very High
Nociception 15 96.12 Very High Very High Very High
Death 33 91.08 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 90.68 High High
Pain 23 85.12 High High
Injury 45 84.72 Quite High
Spinal Cord Injury 37 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (regulation) of Gene_expression (expression) of P75 in motoneurons
1) Confidence 0.53 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
Low-affinity nerve growth factor receptor expression in sciatic nerve during P2-peptide induced experimental allergic neuritis.
Positive_regulation (induced) of in nerve Gene_expression (expression) of nerve growth factor receptor in sciatic nerve associated with nerve growth factor, experimental autoimmune neuritis, sciatic nerve and neuritis
2) Confidence 0.48 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 8584242 Disease Relevance 0.63 Pain Relevance 0.72
The evidence that EV injection in adult rats increases the intraovarian synthesis of both NGF and p75NTR [10] suggests a possible functional link between PCO and the NGF/NGF receptor system.
Positive_regulation (increases) of Gene_expression (synthesis) of p75NTR associated with nerve growth factor and polycystic ovary syndrome
3) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.41 Pain Relevance 0.34
Our data suggest that sciatic nerve lesion-induced differential expression of p75NTR in neurons and glia [70] may play a partial role in the enhanced regeneration of ascending sensory neurons.
Positive_regulation (induced) of in sciatic nerve Gene_expression (expression) of p75NTR in neurons associated with sciatic nerve
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.42 Pain Relevance 0.47
However, there were always more cells labeled with p75, suggesting that some cholinergic cells had lost ChAT expression but continued expressing p75 (Figure 1C).
Positive_regulation (lost) of Gene_expression (expressing) of p75
5) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.13 Pain Relevance 0.10
However, there were always more cells labeled with p75, suggesting that some cholinergic cells had lost ChAT expression but continued expressing p75 (Figure 1C).
Positive_regulation (lost) of Gene_expression (expressing) of p75
6) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.13 Pain Relevance 0.10
Our previous studies revealed that a neonatal inflammatory stimulus resulted in an increase in the expression of the neurotrophin receptor gene in dorsal root ganglia during the early postnatal period[6].
Positive_regulation (increase) of Gene_expression (expression) of neurotrophin receptor gene in dorsal root ganglia associated with inflammatory stimuli
7) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978219 Disease Relevance 0.83 Pain Relevance 0.98

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