INT61542

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 6.35
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
sciatic nerve 2
neurons 2
nerve 2
urinary bladder 1
brain 1
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 100.00 Very High Very High Very High
Thalamus 2 100.00 Very High Very High Very High
algogenic 2 99.98 Very High Very High Very High
Nerve growth factor 88 99.96 Very High Very High Very High
Sciatic nerve 79 99.68 Very High Very High Very High
Acupuncture 82 99.42 Very High Very High Very High
cerebral cortex 2 99.40 Very High Very High Very High
Pain 13 99.16 Very High Very High Very High
Neuritis 10 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 11 99.80 Very High Very High Very High
Death 20 99.76 Very High Very High Very High
Nociception 7 99.50 Very High Very High Very High
Immunization 4 99.36 Very High Very High Very High
Experimental Autoimmune Neuritis 10 98.88 Very High Very High Very High
Injury 36 98.16 Very High Very High Very High
INFLAMMATION 9 97.96 Very High Very High Very High
Apoptosis 16 97.76 Very High Very High Very High
Reprotox - General 1 2 97.28 Very High Very High Very High
Inflammatory Pain 6 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP and p75NTR immunoreactivity was upregulated in the CFA + saline groups compared with a control group (p<.01).
Positive_regulation (upregulated) of p75NTR
1) Confidence 0.70 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.06 Pain Relevance 0
Our results showed that both p75NGFR mRNA and protein were induced within sciatic nerve by day 18 and 23 after 'SP26' immunization.
Positive_regulation (induced) of p75NGFR mRNA in sciatic nerve associated with immunization and sciatic nerve
2) Confidence 0.67 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584242 Disease Relevance 0.69 Pain Relevance 0.73
Increase of p75 immunoreactivity in rat urinary bladder following inflammation.
Positive_regulation (Increase) of p75 in urinary bladder associated with inflammation
3) Confidence 0.49 Published 1996 Journal Neuroreport Section Title Doc Link 8817519 Disease Relevance 0.37 Pain Relevance 0.36
Results show that p75 is up-regulated in inflamed tissues, suggesting that p75 may bind to and take up nerve growth factor (NGF), thus participating in NGF-induced hyperalgesia.
Positive_regulation (up-regulated) of p75 in nerve associated with hyperalgesia and nerve growth factor
4) Confidence 0.49 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817519 Disease Relevance 0.41 Pain Relevance 0.39
These data demonstrate that, during EAN induced by immunization with 100 micrograms of 'SP26', p75NGFR is up-regulated in Schwann cells and in nerve fibers distally along the nerve.
Positive_regulation (up-regulated) of p75NGFR in nerve associated with immunization and neuritis
5) Confidence 0.48 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584242 Disease Relevance 0.67 Pain Relevance 0.72
Our previous studies showed that sciatic nerve transection significantly increased p75NTR in glia but decreased p75NTR in neurons in the DRG [35]. p75NTR expression in glial cells may have a role in nerve regeneration opposing that in neurons [68], [69].
Positive_regulation (increased) of p75NTR in neurons associated with sciatic nerve
6) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.37 Pain Relevance 0.34
When P7 rats (at the peak of brain development) were exposed to a commonly-used and highly pro-apoptotic anesthesia protocol (midazolam, isoflurane, nitrous oxide) for a period of 2, 4 or 6 h, we found that anesthesia modulates the key steps in BDNF-activated apoptotic cascade in two of the most vulnerable brain regions--cerebral cortex and thalamus in time-dependent fashion by activating both Trk-dependent (in thalamus) and Trk-independent p75NTR dependent (in cerebral cortex) neurotrophic pathways. beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis.
Positive_regulation (activating) of p75NTR in brain associated with anesthesia, versed, thalamus, isoflurane, apoptosis and cerebral cortex
7) Confidence 0.45 Published 2006 Journal Apoptosis Section Abstract Doc Link 16738805 Disease Relevance 0.34 Pain Relevance 0.69
That EA counteracted the EV-induced increase in ovarian expression and amount of p75NTR supports this hypothesis.
Positive_regulation (increase) of p75NTR associated with acupuncture
8) Confidence 0.44 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.42 Pain Relevance 0.39
This study examined suppression of pain behavior and expression of pain-inducing neuropeptides such as calcitonin gene-related peptide (CGRP) and p75NTR in dorsal root ganglia neurons by a p75NTR inhibitory antibody in a rat model of wrist joint inflammatory pain.
Spec (examined) Positive_regulation (inducing) of p75NTR in neurons associated with pain, algogenic, ipn, neuropeptide and calcitonin gene-related peptide
9) Confidence 0.44 Published 2010 Journal J Hand Surg Am Section Abstract Doc Link 20060234 Disease Relevance 1.13 Pain Relevance 1.22
These results indicate that NGF can increase the excitability of nociceptive sensory neurons through activation of the p75 neurotrophin receptor and its consequent liberation of ceramide from neuronal sphingomyelins.
Positive_regulation (activation) of p75 neurotrophin receptor in neuronal associated with nociception and nerve growth factor
10) Confidence 0.41 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276244 Disease Relevance 0.21 Pain Relevance 0.42
TrkA, TrkB, and NGF mRNA levels decreased, whereas p75 mRNA increased, in ipsilateral SNL NuGr compared with SHAM; BDNF was undetectable.
Positive_regulation (increased) of p75 in NuGr associated with nerve growth factor
11) Confidence 0.37 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.40 Pain Relevance 0.54
However, there were always more cells labeled with p75, suggesting that some cholinergic cells had lost ChAT expression but continued expressing p75 (Figure 1C).
Positive_regulation (lost) of p75
12) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.13 Pain Relevance 0.10
As well, expression of mRNAs for the neurotrophins NGF, BDNF, and NT-3 was examined. p75, trkA, and GAP-43 mRNAs were upregulated in DRGs from the NGF-treated, but not the control animals.
Positive_regulation (upregulated) of p75 in DRGs
13) Confidence 0.27 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.15 Pain Relevance 0
Injury to the sciatic nerve leads to the transganglionic degeneration of sensory axons and to the induction of neurotrophins and p75 nerve growth factor receptor synthesis by the denervated Schwann cells.
Positive_regulation (induction) of p75 in sciatic nerve associated with nerve growth factor, injury and sciatic nerve
14) Confidence 0.13 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8951669 Disease Relevance 0.17 Pain Relevance 0.36
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of neurotrophin receptor in spinal associated with paracetamol and somatostatin
15) Confidence 0.12 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.91
3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.
Positive_regulation (induction) of p75NTR-dependent associated with reprotox - general 1 and death
16) Confidence 0.00 Published 2009 Journal Cancer Prev Res (Phila Pa) Section Title Doc Link 19470787 Disease Relevance 0.72 Pain Relevance 0.17

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