INT61547

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2011
Negated 4
Speculated 3
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 7.23
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
astrocytes 4
fibroblast 2
capillary 2
brain 1
nucleus 1
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 1 99.98 Very High Very High Very High
Substantia nigra 13 99.68 Very High Very High Very High
Central nervous system 96 99.28 Very High Very High Very High
Endep 3 99.00 Very High Very High Very High
antidepressant 37 98.32 Very High Very High Very High
Angina 4 97.56 Very High Very High Very High
cytokine 52 97.24 Very High Very High Very High
agonist 49 97.22 Very High Very High Very High
cINOD 6 97.20 Very High Very High Very High
depression 8 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 1 99.96 Very High Very High Very High
Cardiomyopathy 56 99.24 Very High Very High Very High
Ulcers 52 99.22 Very High Very High Very High
Uremia 90 98.94 Very High Very High Very High
Coronary Artery Disease 10 98.48 Very High Very High Very High
Cv General 3 Under Development 4 97.56 Very High Very High Very High
Pituitary Cancer 11 97.04 Very High Very High Very High
Depression 10 96.76 Very High Very High Very High
Cancer 26 95.84 Very High Very High Very High
Synovitis 6 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, up-regulation of FGF-2 in Schwann cells occurs only when the peripheral nerves are injured [6].
Regulation (regulation) of FGF-2 in peripheral nerves
1) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.21 Pain Relevance 0.06
The results suggest that elevated levels of intrathecal FGF-2 affect sensory processing by depressing low-threshold mechanoreception.
Regulation (affect) of FGF-2 associated with intrathecal
2) Confidence 0.45 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584269 Disease Relevance 0.10 Pain Relevance 0.27
These results indicate that its action as a mitogen stimulus is the major effect of bFGF on salivary gland cells and mucosal epithelium.
Regulation (effect) of bFGF in salivary gland
3) Confidence 0.45 Published 2000 Journal Adv. Dent. Res. Section Abstract Doc Link 11842932 Disease Relevance 0.07 Pain Relevance 0.09
The effects of different concentrations of bFGF on the second passage of these cultured cells were examined.
Spec (examined) Regulation (effects) of bFGF
4) Confidence 0.45 Published 2000 Journal Adv. Dent. Res. Section Abstract Doc Link 11842932 Disease Relevance 0.07 Pain Relevance 0
In oligodendrocytes, it also decreased with cAMP, but increased under the effect of bFGF and PDGF-BB.
Regulation (effect) of bFGF in oligodendrocytes
5) Confidence 0.42 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.08 Pain Relevance 0.40
Moreover, dexamethasone, a potent synthetic glucocorticoid agonist, was shown to induce the FGF-2 gene expression in primary culture of rat astrocytes from different CNS regions [86], and also to increase FGF-2 immunoreactivity in the substantia nigra astrocytes [88], further emphasizing the influence of steroid hormones on astroglial FGF-2 mechanisms.
Regulation (influence) of FGF-2 in astrocytes associated with substantia nigra, agonist, central nervous system and dexamethasone
6) Confidence 0.39 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.20 Pain Relevance 0.24
Actually, a transient down regulation of neuronal FGF-2 immunoreactivity in the ipsilateral axotomized hypoglossal nucleus was described [63], however major events showed by our group have been the upregulation of astroglial FGF-2 in the axotomized hypoglossal nucleus [15] and facial nucleus (this paper).
Regulation (regulation) of FGF-2 in nucleus
7) Confidence 0.39 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.06 Pain Relevance 0.08
Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane.
Regulation (effects) of FGF-2 in brain associated with halothane and brain injury
8) Confidence 0.38 Published 2000 Journal J. Neurotrauma Section Title Doc Link 11101209 Disease Relevance 0.29 Pain Relevance 0.27
Fgf2 protein and mRNA expression were not normalized by insulin treatment, with levels remaining significantly elevated compared to controls (Figure 7).
Neg (not) Regulation (normalized) of Fgf2
9) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.24 Pain Relevance 0
, IL-1 and basic fibroblast growth factor (bFGF)) without affecting neovascularization.
Regulation (affecting) of bFGF in fibroblast
10) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.21 Pain Relevance 0.39
Although an increasing number of studies have pointed out the role of FGF-2 following cellular lesion, few works have attempted to investigate cellular regulation of FGF-2 in response to axotomy of the peripheral motoneurons.
Spec (investigate) Regulation (regulation) of FGF-2 in motoneurons
11) Confidence 0.27 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.27 Pain Relevance 0.17
The two-color immunoperoxidase procedure for the simultaneous detection of the FGF-2 and GFAP immunoreactivities revealed that the vast majority of the nuclear FGF-2 immunoreactive cell profiles were GFAP positive astrocytes in the rat facial nuclei (Figure 4).
Regulation (immunoreactivities) of FGF-2 in astrocytes
12) Confidence 0.27 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.08 Pain Relevance 0
In this experiment, FGF-2 immunoreactivity was located in the nucleus of astrocytes in the same manner that was found in the other two experiments, however astrocyte have not become reactive after functional electrical stimulation (data not shown).


Regulation (immunoreactivity) of FGF-2 in astrocytes
13) Confidence 0.27 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.06 Pain Relevance 0
Moreover, dexamethasone, a potent synthetic glucocorticoid agonist, was shown to induce the FGF-2 gene expression in primary culture of rat astrocytes from different CNS regions [86], and also to increase FGF-2 immunoreactivity in the substantia nigra astrocytes [88], further emphasizing the influence of steroid hormones on astroglial FGF-2 mechanisms.
Regulation (immunoreactivity) of FGF-2 in astrocytes associated with substantia nigra, agonist, central nervous system and dexamethasone
14) Confidence 0.27 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.25 Pain Relevance 0.24
Basic fibroblast growth factor changes in response to coronary angioplasty in patients with stable angina.
Regulation (changes) of Basic fibroblast growth factor in fibroblast associated with angina
15) Confidence 0.27 Published 2002 Journal Int. J. Cardiol. Section Title Doc Link 12127372 Disease Relevance 0.34 Pain Relevance 0.15
Thus, bFGF level may change in response to PTCA in patients with coronary artery disease and stable angina.
Spec (may) Regulation (change) of bFGF in coronary artery associated with angina and coronary artery disease
16) Confidence 0.27 Published 2002 Journal Int. J. Cardiol. Section Abstract Doc Link 12127372 Disease Relevance 0.50 Pain Relevance 0.17
The different changes in interstitial and capillary density in uraemic cardiomyopathy have not yet been explained, but the role of growth factors such as basic fibroblast growth factor (BFGF) and vascular endothelial growth factor (VEGF) has been proposed [44].
Regulation (role) of basic fibroblast growth factor in capillary associated with cardiomyopathy and uremia
17) Confidence 0.23 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.74 Pain Relevance 0.03
The different changes in interstitial and capillary density in uraemic cardiomyopathy have not yet been explained, but the role of growth factors such as basic fibroblast growth factor (BFGF) and vascular endothelial growth factor (VEGF) has been proposed [44].
Regulation (role) of BFGF in capillary associated with cardiomyopathy and uremia
18) Confidence 0.23 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.74 Pain Relevance 0.03
By contrast, NSAIDs, cyclooxygenase-2 (COX-2) inhibitors, and alendronate have been shown to delay the healing of ulcers, and impair angiogenesis and the down regulation of growth factors such as bFGF and VEGF (17-19).
Regulation (regulation) of bFGF associated with ulcers and cinod
19) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877244 Disease Relevance 0.83 Pain Relevance 0.10
Two patterns of expression were evident with one set of proteins regulated at both the transcript and protein levels (Cp, Lgals3, Fgf2, and Stat3) (Figure 5) and another set with altered protein expression but no significant changes in transcript expression (Cryaa, Cryab, Cryba3, Crybb2, Dbi, and Anxa5) (Figure 6).
Regulation (regulated) of Fgf2
20) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0 Pain Relevance 0

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