INT61548

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2011
Negated 4
Speculated 4
Reported most in Abstract
Documents 72
Total Number 82
Disease Relevance 32.18
Pain Relevance 14.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
nucleus 8
fibroblast 6
astrocytes 5
retina 4
brain 4
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 227 100.00 Very High Very High Very High
Nerve growth factor 100 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
intrathecal 1 100.00 Very High Very High Very High
fluoxetine 85 99.98 Very High Very High Very High
Spinal cord 73 99.84 Very High Very High Very High
cytokine 99 99.82 Very High Very High Very High
Desipramine 15 99.82 Very High Very High Very High
Hippocampus 37 99.76 Very High Very High Very High
Clonidine 16 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 145 100.00 Very High Very High Very High
Aids-related Complex 20 100.00 Very High Very High Very High
Leukemia 3 100.00 Very High Very High Very High
Diabetes Mellitus 515 99.84 Very High Very High Very High
Ulcers 11 99.84 Very High Very High Very High
Bone Fracture 8 99.74 Very High Very High Very High
Hydrocephalus 54 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.28 Very High Very High Very High
Coronary Artery Disease 12 99.28 Very High Very High Very High
Disease 282 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single injection of xylazine or clonidine transiently increased bFGF mRNA.
Positive_regulation (increased) of bFGF associated with clonidine
1) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.47
No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection.
Neg (No) Positive_regulation (increase) of bFGF in brain associated with clonidine
2) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.49
We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the alpha 2-adrenergic agonists xylazine and clonidine.
Positive_regulation (induction) of bFGF in retina associated with agonist and clonidine
3) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.42
The present findings are in line with our previous observations that adrenocortical steroid administration can increase FGF-2 mainly in the glial cells of the rat substantia nigra [9].
Positive_regulation (increase) of FGF-2 in glial cells associated with substantia nigra
4) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.26 Pain Relevance 0.22
We should emphasize that based on the results presented in this report, the functional electrical stimulation led to elevation of FGF-2 mainly in the cytoplasm of neurons of facial nucleus, which differed to the findings of systemic corticosterone that promoted elevation of FGF-2 in the nuclei of astrocytes of facial nucleus.
Positive_regulation (elevation) of FGF-2 in nucleus
5) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.08 Pain Relevance 0
All in all, the above considerations seem to be in line with our results regarding the increases of FGF-2 in the facial nuclei of rats submitted to a functional electrical stimulation applied in a facial muscle after local implantation of an electrode.
Positive_regulation (increases) of FGF-2 in facial muscle
6) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.14 Pain Relevance 0
We have shown in this study that systemic corticosterone for 7 days led to upregulation of FGF-2 immunoreactivity mainly in astrocytes of rat facial nucleus.
Positive_regulation (upregulation) of FGF-2 in nucleus
7) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.29 Pain Relevance 0.18
An important finding of the present work was the substantial increases of FGF-2 in the reactive astrocytes of axotomized facial nuclei.
Positive_regulation (increases) of FGF-2 in astrocytes
8) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.27 Pain Relevance 0.06
We can not exclude the possibility of retrograde signals may have triggered the increases of FGF-2 in the neuronal cells of facial nucleus after the functional electrical stimulation performed in our works, however it seems possible that proprioceptive reflexes might have exerted an important role in that process.
Positive_regulation (increases) of FGF-2 in nucleus
9) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.06 Pain Relevance 0
We should emphasize that based on the results presented in this report, the functional electrical stimulation led to elevation of FGF-2 mainly in the cytoplasm of neurons of facial nucleus, which differed to the findings of systemic corticosterone that promoted elevation of FGF-2 in the nuclei of astrocytes of facial nucleus.
Positive_regulation (elevation) of FGF-2 in nucleus
10) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.09 Pain Relevance 0
The increase in FGF2 mRNA after a single injection was seen only at 5 h after the injection and was restricted to the entorhinal cortex, whereas the effect of the long-term treatments lasted up to 24 h and occurred in the entire cortex and hippocampus.
Positive_regulation (increase) of FGF2 mRNA in hippocampus associated with hippocampus
11) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.73
DMI and MIA increased FGF2 proteins predominantly in neurons of layer V throughout the cerebral cortex and in some neurofilament-positive cells of the hippocampus.
Positive_regulation (increased) of FGF2 in hippocampus associated with desipramine, hippocampus and cerebral cortex
12) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.80
RNase protection assay and Western blot analysis revealed that all antidepressant drugs elicited an anatomically specific increase in FGF2 mRNA and protein.
Positive_regulation (increase) of FGF2 mRNA associated with antidepressant
13) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.70
Fibroblast growth factor-2 (FGF-2), a neurotrophic and gliogenic factor, is upregulated by spinal cord astrocytes in response to ligation of spinal nerves L5 and L6 (spinal nerve ligation [SpNL]).
Positive_regulation (upregulated) of FGF-2 in astrocytes associated with spinal nerve ligature and spinal cord
14) Confidence 0.70 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16280602 Disease Relevance 0.80 Pain Relevance 0.73
Conversely, chronic treatment with a combination of FLX and OLA (FLX+OLA) increased FGF-2 mRNA levels in prefrontal cortex, as well as in hippocampus and striatum.
Positive_regulation (increased) of FGF-2 mRNA in cortex
15) Confidence 0.69 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
RESULTS: After single injection, we found that FGF-2 mRNA levels were selectively upregulated in the prefrontal cortex only when the two drugs were coadministered, an effect paralleled by a significant increase of phosphorylated protein kinase B (P-Akt) levels.
Positive_regulation (upregulated) of FGF-2 mRNA in cortex
16) Confidence 0.69 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
In conclusion, these findings show that bFGF levels are elevated in patients with coronary artery disease.
Positive_regulation (elevated) of bFGF in coronary artery associated with coronary artery disease
17) Confidence 0.69 Published 2002 Journal Int. J. Cardiol. Section Abstract Doc Link 12127372 Disease Relevance 0.32 Pain Relevance 0.16
We sought to determine whether bFGF might be similarly elevated in patients with clinical evidence of limb ischemia.
Spec (might) Positive_regulation (elevated) of bFGF in limb associated with ischemia
18) Confidence 0.64 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8892777 Disease Relevance 0.51 Pain Relevance 0.14
In conclusion, circulating levels of bFGF are elevated in patients with vascular insufficiency and may reflect a physiologic response to limb ischemia.
Positive_regulation (elevated) of bFGF in limb associated with ischemia and increased venous pressure under development
19) Confidence 0.64 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8892777 Disease Relevance 0.75 Pain Relevance 0.22
Increased levels and activity of bFGF have been documented in a variety of diseases, including tumors.
Positive_regulation (Increased) of bFGF associated with cancer and disease
20) Confidence 0.64 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8892777 Disease Relevance 0.44 Pain Relevance 0.08

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