INT61585

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 6.52
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (NALCN)
Anatomy Link Frequency
fibroblasts 7
neuronal 2
skeletal muscle 1
brain 1
soma 1
NALCN (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 421 100.00 Very High Very High Very High
Glutamate 4 99.80 Very High Very High Very High
Pain 21 99.48 Very High Very High Very High
gABA 16 99.22 Very High Very High Very High
potassium channel 17 98.96 Very High Very High Very High
imagery 3 98.48 Very High Very High Very High
Cannabinoid receptor 3 97.40 Very High Very High Very High
Calcium channel 16 96.80 Very High Very High Very High
Cannabinoid 8 96.04 Very High Very High Very High
Central nervous system 36 94.72 High High
Disease Link Frequency Relevance Heat
Nociception 5 99.84 Very High Very High Very High
Pain 17 99.48 Very High Very High Very High
Channelopathies 9 97.76 Very High Very High Very High
Injury 17 97.36 Very High Very High Very High
Myocardial Infarction 22 95.20 Very High Very High Very High
Hypertrophy 9 94.60 High High
Hyperalgesia 7 93.60 High High
Glioma 3 90.72 High High
Toxicity 1 87.36 High High
Dry Eye 2 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review focuses on the pathogenic mechanisms of channelopathies affecting skeletal muscle and brain arising from mutations of voltage-gated ion channels and fast ligand-gated ion channels expressed at the surface membrane.
Gene_expression (expressed) of ion in brain associated with channelopathies
1) Confidence 0.52 Published 2006 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 16776591 Disease Relevance 0.74 Pain Relevance 0.08
Similarity of ion channels to cellular automata
Gene_expression (channels) of ion
2) Confidence 0.42 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1360660 Disease Relevance 0 Pain Relevance 0.05
The maximum open and closed times for various ion channels were obtained [43-54] and the open to closed cycle was used as the duration of memory in single ion channels.
Gene_expression (channels) of ion
3) Confidence 0.42 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1360660 Disease Relevance 0 Pain Relevance 0
Duration of memory versus the number of ion channels
Gene_expression (channels) of ion
4) Confidence 0.42 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1360660 Disease Relevance 0 Pain Relevance 0
Nerves destroyed by injury soon start to regenerate and form microneuromas that exhibit abnormal responsiveness and spontaneous discharges, due to an altered expression of ion channel proteins in the soma and in regenerating nerve terminals.
Gene_expression (expression) of ion in soma associated with injury
5) Confidence 0.28 Published 2004 Journal Exp. Eye Res. Section Abstract Doc Link 15106930 Disease Relevance 0.96 Pain Relevance 0.80
Ion channels expressed by immune system cells (e.g.
Gene_expression (expressed) of Ion in immune system
6) Confidence 0.19 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20142270 Disease Relevance 0.96 Pain Relevance 1.22
This review focuses on the pathogenic mechanisms of channelopathies affecting skeletal muscle and brain arising from mutations of voltage-gated ion channels and fast ligand-gated ion channels expressed at the surface membrane.
Gene_expression (expressed) of ion in skeletal muscle associated with channelopathies
7) Confidence 0.18 Published 2006 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 16776591 Disease Relevance 0.74 Pain Relevance 0.08
Modulation of transducer ion channels expressed at nociceptive terminals occurs upon activation of metabotropic cannabinoid receptors, but direct cannabinoid action on ion channels involved in sensory transduction or regulation of neuron excitability likely contributes to the peripheral cannabinoid effects.
Gene_expression (expressed) of ion in neuron associated with nociception, cannabinoid receptor and cannabinoid
8) Confidence 0.08 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19306092 Disease Relevance 0.50 Pain Relevance 0.78
Although the expression of ion channels and receptors vary considerably between different cell lines and comparative studies are rare, a few differences (compared to astrocytes in primary culture) have been identified which may turn out to be characteristic for glioma cells.
Gene_expression (expression) of ion in astrocytes associated with glioma
9) Confidence 0.06 Published 1995 Journal Glia Section Abstract Doc Link 8586460 Disease Relevance 0.29 Pain Relevance 0.36
Potent general depressant and anesthetic actions of propofol provide the basis for the assumption that it produces these effects, through its counteraction not only with GABA, but also with the glutamate-gated ion channels.
Gene_expression (channels) of ion associated with glutamate and gaba
10) Confidence 0.05 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0 Pain Relevance 0.46
A whole-cell patch voltage clamp technique and RT-PCR were employed to determine ion channels expression and their molecular identities.
Spec (determine) Gene_expression (expression) of ion
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0
We found that multiple ion channels were heterogeneously expressed in human cardiac fibroblasts.
Gene_expression (expressed) of ion in fibroblasts
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.05
Consequently, a subpopulation of human cardiac fibroblasts may display different patterns of ion channel expression.
Gene_expression (expression) of ion in fibroblasts
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.06 Pain Relevance 0.08
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (expressed) of ion in fibroblasts associated with tetrodotoxin
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.14 Pain Relevance 0.10
No difference in cell growth and ion channel expression were observed with either our culture medium or the medium from ScienCell Research Laboratory.
Gene_expression (expression) of ion
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0
These results suggested that multiple functional ion channel currents, IK(Ca), IK(DR), I(to), I(Na), and K(ir), are expressed in hUC-MSCs.
Gene_expression (expressed) of ion
16) Confidence 0.04 Published 2007 Journal Stem Cells Section Abstract Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.09
Functional expression of ion channels in mesenchymal stem cells derived from umbilical cord vein.
Gene_expression (expression) of ion in stem cells
17) Confidence 0.04 Published 2007 Journal Stem Cells Section Title Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.05
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (channels) of ion in fibroblasts associated with tetrodotoxin
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.14 Pain Relevance 0.10
Ion channels and their functions are well studied in cardiomyocytes; however, the ion channel expression and their physiological roles are not fully understood in cardiac fibroblasts.
Gene_expression (expression) of ion in fibroblasts
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.48 Pain Relevance 0.03
Using these techniques, we identified multiple ion channels expressed in cultured human cardiac fibroblasts.


Gene_expression (expressed) of ion in fibroblasts
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0

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