INT61599

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 43
Total Number 44
Disease Relevance 11.10
Pain Relevance 8.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
Blood 3
hepatocytes 3
liver 2
lung 1
hearts 1
CYP2C9 (Homo sapiens)
CYP2C9 - I359L (1) CYP2C9 - A1061C (1)
Pain Link Frequency Relevance Heat
fluoxetine 19 100.00 Very High Very High Very High
diclofenac 5 100.00 Very High Very High Very High
Potency 3 100.00 Very High Very High Very High
cINOD 33 99.98 Very High Very High Very High
Opioid 6 99.24 Very High Very High Very High
opioid receptor 1 99.24 Very High Very High Very High
agonist 15 99.20 Very High Very High Very High
tricyclic antidepressant 5 98.48 Very High Very High Very High
Oxycodone 1 97.28 Very High Very High Very High
Inflammation 25 97.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 154 99.80 Very High Very High Very High
INFLAMMATION 46 99.60 Very High Very High Very High
Fatty Liver 63 98.16 Very High Very High Very High
Toxicity 27 97.80 Very High Very High Very High
Hypoxia 4 97.32 Very High Very High Very High
Pulmonary Hypertension 368 96.88 Very High Very High Very High
Stress 17 96.28 Very High Very High Very High
Non-genital Cutaneous Warts 6 94.56 High High
Diabetes Mellitus 19 94.04 High High
Hypertension 11 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, we have demonstrated rifampicin induction of CYP2C9 promoter constructs that is consistent with the magnitude of induction of CYP2C9 protein and mRNA reported in vivo and in primary human hepatocytes, and we have identified the cis-element essential for this response.
Positive_regulation (induction) of CYP2C9 protein in hepatocytes
1) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.18 Pain Relevance 0.08
Deletion and mutagenesis studies with luciferase reporter constructs showed that a functional PXR-responsive element located -1839/-1824 base pairs upstream from the translation start site was the primary binding site mediating the rifampicin induction of CYP2C9.
Positive_regulation (induction) of CYP2C9
2) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.24 Pain Relevance 0.11
In the present study, we demonstrate that the human pregnane X receptor (hPXR) mediates induction of CYP2C9 by the prototype drugs rifampicin, hyperforin (found in St.
Positive_regulation (induction) of CYP2C9
3) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.27 Pain Relevance 0.13
This is the first report to demonstrate that the nuclear receptor PXR mediates induction of CYP2C9 with rifampicin, phenobarbital, and hyperforin.
Positive_regulation (induction) of CYP2C9
4) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.06 Pain Relevance 0
In summary, we have demonstrated rifampicin induction of CYP2C9 promoter constructs that is consistent with the magnitude of induction of CYP2C9 protein and mRNA reported in vivo and in primary human hepatocytes, and we have identified the cis-element essential for this response.
Positive_regulation (induction) of CYP2C9 promoter in hepatocytes
5) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.19 Pain Relevance 0.09
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Positive_regulation (increased) of CYP2C9 mRNA in hearts associated with hypoxia
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.26 Pain Relevance 0
Several studies have reported that certain drugs such as rifampicin and phenobarbital induce CYP2C9, but the molecular basis for this induction remains unknown.
Positive_regulation (induce) of CYP2C9
7) Confidence 0.60 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.27 Pain Relevance 0.14
Although CYP2C9, CYP2C19 and CYP2E1 are also induced, no specific inducers of CYP2D6 have yet been identified clearly.
Positive_regulation (induced) of CYP2C9
8) Confidence 0.59 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.10 Pain Relevance 0.10
Two common variants of the CYP2C9 gene (CYP2C9*2 and *3) were reported to significantly affect the activity of the CYP2C9 enzyme.
Positive_regulation (variants) of CYP2C9
9) Confidence 0.50 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17681167 Disease Relevance 0.32 Pain Relevance 0.35
Two common variants of the CYP2C9 gene (CYP2C9*2 and *3) were reported to significantly affect the activity of the CYP2C9 enzyme.
Positive_regulation (variants) of CYP2C9
10) Confidence 0.50 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17681167 Disease Relevance 0.32 Pain Relevance 0.35
The single-base mutation of A1061C (Ile359Leu) in the CYP2C9 gene termed CYP2C9*3 was found at a frequency of about 2.1% in Japanese.
Positive_regulation (termed) of CYP2C9
11) Confidence 0.50 Published 1999 Journal Mol. Genet. Metab. Section Abstract Doc Link 10562462 Disease Relevance 0.09 Pain Relevance 0.09
The single-base mutation of A1061C (Ile359Leu) in the CYP2C9 gene termed CYP2C9*3 was found at a frequency of about 2.1% in Japanese.
Positive_regulation (termed) of CYP2C9 gene (A1061C, I359L)
12) Confidence 0.50 Published 1999 Journal Mol. Genet. Metab. Section Abstract Doc Link 10562462 Disease Relevance 0.09 Pain Relevance 0.10
R-Norfluoxetine formation rates in a characterized microsomal bank correlated with the catalytic activities for cytochrome P450 (CYP) 2D6, CYP2C9, and CYP2C8.
Positive_regulation (activities) of CYP2C9
13) Confidence 0.49 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356927 Disease Relevance 0 Pain Relevance 0.15
A very weak time-dependent CYP2C9 inhibitor (AZ1, a proprietary AstraZeneca compound; KI 30 microM and kinact 0.02 min(-1)) effectively abolished CYP2C9 activity over 24 h at low (micromolar) concentrations in primary cultured human hepatocytes.
Positive_regulation (time-dependent) of CYP2C9 in hepatocytes
14) Confidence 0.49 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679385 Disease Relevance 0 Pain Relevance 0.41
The increase in CYP2C9 mRNA, protein, and enzymatic activity during NAFLD progression would suggest that the standard dose of rosiglitazone to treat patients with type II diabetes may be ineffective in managing hyperglycemia in patients with NASH or liver fibrosis.
Positive_regulation (increase) of CYP2C9 in liver associated with hyperglycemia, fatty liver, fibrosis, nash(non-alcoholic steatohepatitis), cirrhosis and diabetes mellitus
15) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.80 Pain Relevance 0.33
CONCLUSION: Piroxicam's oral clearance was impaired and its inhibitory effect on cyclooxygenase 1 activity was increased in CYP2C9*1/*2 or CYP2C9*1/*3 individuals, as compared with CYP2C 9*1 homozygous individuals.


Positive_regulation (increased) of CYP2C9
16) Confidence 0.46 Published 2005 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16198655 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Piroxicam's oral clearance was impaired and its inhibitory effect on cyclooxygenase 1 activity was increased in CYP2C9*1/*2 or CYP2C9*1/*3 individuals, as compared with CYP2C 9*1 homozygous individuals.


Positive_regulation (increased) of CYP2C9
17) Confidence 0.46 Published 2005 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16198655 Disease Relevance 0 Pain Relevance 0
For pharmacokinetic changes of drugs by SJW, induction of cytochrome P450s (e.g.
Positive_regulation (induction) of CYP2C9
18) Confidence 0.43 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18673195 Disease Relevance 0.14 Pain Relevance 0.24
Although phenprocoumon is less dependent on CYP2C9 for its elimination compared to acenocoumarol, polymorphisms in CYP2C9 have been associated with an increased risk of overanticoagulation and bleedings for both drugs [45–48].
Positive_regulation (dependent) of CYP2C9
19) Confidence 0.43 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958670 Disease Relevance 0.06 Pain Relevance 0.04
This electrophilic alpha, beta-unsaturated aldehyde represents a possible reactive intermediate that bioalkylates P450 2C9.
Spec (possible) Positive_regulation (bioalkylates) of P450 2C9
20) Confidence 0.42 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 14570769 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox