INT616

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Context Info
Confidence 0.38
First Reported 1976
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.72
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Orm1) extracellular space (Orm1) extracellular region (Orm1)
Anatomy Link Frequency
plasma 2
liver 1
brain 1
Orm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 8 99.78 Very High Very High Very High
Arthritis 2 99.32 Very High Very High Very High
Inflammation 7 98.32 Very High Very High Very High
alcohol 2 87.36 High High
Paracetamol 1 85.52 High High
methadone 2 77.76 Quite High
cINOD 1 60.88 Quite High
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 11 100.00 Very High Very High Very High
Experimental Arthritis 2 99.68 Very High Very High Very High
INFLAMMATION 7 98.32 Very High Very High Very High
Poisoning 1 75.52 Quite High
Acute-phase Reaction 1 75.00 Quite High
Pressure And Volume Under Development 1 72.44 Quite High
Toxicity 2 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this work was to check the effects of alpha-1 acid glycoprotein (AAG) and of its components, A and F1/S genetic variants, on the brain transfer of drugs they bind in plasma.
Regulation (effects) of alpha-1 acid glycoprotein in brain
1) Confidence 0.38 Published 1998 Journal Life Sci. Section Abstract Doc Link 9570346 Disease Relevance 0 Pain Relevance 0.08
The influence of liver injury on the plasma concentrations of alpha 1-acid glycoprotein (AGP) and albumin was examined in several different models of chemically-induced liver injury.
Regulation (influence) of AGP in plasma associated with injury
2) Confidence 0.31 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1446373 Disease Relevance 0.61 Pain Relevance 0.16
A discussion of the role of the liver in controlling inflammatory events, in relation to the synthesis of an anti-inflammatory protein has been given; the present work is an extension of this and describes the changes in concentration and synthesis rate of albumin, fibrinogen and alpha1 acid glycoprotein during adjuvant arthritis in the rat.
Regulation (changes) of acid glycoprotein in liver associated with inflammation, experimental arthritis and arthritis
3) Confidence 0.21 Published 1976 Journal Agents Actions Section Abstract Doc Link 60050 Disease Relevance 1.10 Pain Relevance 0.40
Plasma levels of lidocaine and the main binding proteins of lidocaine in plasma alpha1-acid glycoprotein (AAG) and albumin were measured in 10 otherwise healthy women during and after breast augmentation.
Regulation (measured) of alpha1-acid glycoprotein in plasma associated with lidocaine
4) Confidence 0.01 Published 1999 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 10088519 Disease Relevance 0 Pain Relevance 0.44

General Comments

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