INT61617

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 1995
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.13
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
fibroblasts 2
HGF 2
PTGER2 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 99.68 Very High Very High Very High
pulpitis 2 99.56 Very High Very High Very High
cytokine 11 99.24 Very High Very High Very High
Inflammation 3 93.84 High High
COX-2 inhibitor 1 67.92 Quite High
Inflammatory mediators 1 65.00 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pulpitis 2 99.56 Very High Very High Very High
INFLAMMATION 7 99.28 Very High Very High Very High
Periodontitis 3 96.92 Very High Very High Very High
Periodontal Disease 1 95.72 Very High Very High Very High
Necrosis 1 92.24 High High
Cancer 1 91.88 High High
Pulmonary Sarcoidosis 1 78.56 Quite High
Uveitis 1 77.56 Quite High
Disease 1 33.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To gain further insight into the molecular pathogenesis of pulpitis, we investigated the effects of IL-1alpha or TNF-alpha and PGE2, either alone or in combination on IL-6 and cyclooxygenase (COX)-2 messenger RNA (mRNA) production in cultured human dental pulp (HDP) fibroblasts.
PGE2 Spec (investigated) Regulation (effects) of Gene_expression (production) of IL-6 in fibroblasts associated with pulpitis
1) Confidence 0.11 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.28 Pain Relevance 0.20
PGE2 is important in regulating IL-6 production.
PGE2 Regulation (regulating) of Gene_expression (production) of IL-6
2) Confidence 0.08 Published 2003 Journal J. Periodontol. Section Abstract Doc Link 14974816 Disease Relevance 0.46 Pain Relevance 0.27
These results suggest the endogenous PGE2 induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF.
PGE2 Regulation (role) of Gene_expression (production) of IL 6 in HGF
3) Confidence 0.06 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8841895 Disease Relevance 0.16 Pain Relevance 0.23
The effects of PGE2 on IL-6 production also varied among TCC.
PGE2 Regulation (effects) of Gene_expression (production) of IL-6
4) Confidence 0.05 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.23 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox