INT61619

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 5
Speculated 9
Reported most in Body
Documents 194
Total Number 203
Disease Relevance 146.07
Pain Relevance 41.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
T cells 16
macrophages 14
monocytes 11
lung 7
dendritic cells 5
IL12A (Homo sapiens)
IL12A - R753Q (1)
Pain Link Frequency Relevance Heat
cytokine 4724 100.00 Very High Very High Very High
Inflammation 3614 100.00 Very High Very High Very High
Enkephalin 12 99.40 Very High Very High Very High
adenocard 33 99.30 Very High Very High Very High
cINOD 81 99.24 Very High Very High Very High
Opioid 74 99.24 Very High Very High Very High
agonist 329 99.20 Very High Very High Very High
Neuritis 23 99.06 Very High Very High Very High
Inflammatory response 294 98.88 Very High Very High Very High
rheumatoid arthritis 977 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4114 100.00 Very High Very High Very High
Cancer 2934 100.00 Very High Very High Very High
Adenocarcinoma 1205 100.00 Very High Very High Very High
Necrosis 188 100.00 Very High Very High Very High
Asthma 3726 99.90 Very High Very High Very High
Otitis Media 944 99.84 Very High Very High Very High
Non-small-cell Lung Cancer 360 99.84 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.84 Very High Very High Very High
Lymphatic System Cancer 51 99.84 Very High Very High Very High
Mycobacterial Infection 109 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because we have observed marked defects in interleukin-12 (IL-12) production in CTCL and because IL-12 is critical for antitumor cytotoxic T-cell responses, we initiated a phase I dose escalation trial with recombinant human IL-12 (rhIL-12) where patients received either 50, 100, or 300 ng/kg rhIL-12 twice weekly subcutaneously or intralesionally for up to 24 weeks.
Gene_expression (production) of interleukin-12 in cytotoxic T-cell associated with lymphatic system cancer
1) Confidence 0.77 Published 1999 Journal Blood Section Abstract Doc Link 10419880 Disease Relevance 0.56 Pain Relevance 0.05
Because we have observed marked defects in interleukin-12 (IL-12) production in CTCL and because IL-12 is critical for antitumor cytotoxic T-cell responses, we initiated a phase I dose escalation trial with recombinant human IL-12 (rhIL-12) where patients received either 50, 100, or 300 ng/kg rhIL-12 twice weekly subcutaneously or intralesionally for up to 24 weeks.
Gene_expression (production) of IL-12 in cytotoxic T-cell associated with lymphatic system cancer
2) Confidence 0.77 Published 1999 Journal Blood Section Abstract Doc Link 10419880 Disease Relevance 0.56 Pain Relevance 0.05
We found that two of the seven HA preparations tested stimulated the synthesis of IL-12 and TNF-alpha by human monocytic cells.
Gene_expression (synthesis) of IL-12
3) Confidence 0.63 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.66 Pain Relevance 0.43
We unexpectedly found that the induction of IL-12 and TNF-alpha by these HA preparations was not due to their degradation to low-molecular-weight fragments, since their native high-molecular-weight forms possessed the same ability to stimulate IL-12 and TNF-alpha synthesis, but was due to the presence of contaminating DNA.
Gene_expression (synthesis) of IL-12
4) Confidence 0.63 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.73 Pain Relevance 0.49
We tested low-molecular-weight fragments obtained from seven different HA preparations, either by sonication (approximately equals 3 x 10(5) Da) or by hyaluronidase digestion (approximately equals 1 x 10(4) Da), for the ability to induce the synthesis of IL-12 and TNF-alpha by human monocytic cells.
Gene_expression (synthesis) of IL-12
5) Confidence 0.63 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.64 Pain Relevance 0.40
The goals of this study were to assess the safety and toxicities as well as the efficacy, and ancillarily the immunomodulatory effects, of peritumoral IL-12 gene transfer.
Gene_expression (transfer) of IL-12 gene
6) Confidence 0.59 Published 2001 Journal Hum. Gene Ther. Section Abstract Doc Link 11426466 Disease Relevance 0.17 Pain Relevance 0
production, levels of IL-12-stimulated IFN-?
Gene_expression (production) of IL-12-stimulated
7) Confidence 0.51 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.67 Pain Relevance 0.34
Cytokine responses indicated either NK or T-cell mediated effects of IP rhIL-12 with results suggesting pleiotropism with endogenous production of immunostimulatory cytokines or chemokines (IFN-?
Gene_expression (effects) of rhIL-12 in T-cell associated with chemokine and cytokine
8) Confidence 0.51 Published 2007 Journal J Transl Med Section Body Doc Link PMC2248163 Disease Relevance 0.29 Pain Relevance 0.22
Through it, IL-12 promotes proliferation of IFN-?
Gene_expression (promotes) of IL-12
9) Confidence 0.48 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.59 Pain Relevance 0.22
Ustekinumab (Stelara®; Centocor, Inc) is a fully human monoclonal antibody targeting IL-12/23.
Gene_expression (targeting) of IL-12
10) Confidence 0.48 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.64 Pain Relevance 0.28
Effect of IL-12 and IL-18 on PHA/PMA-stimulated PBMCs
Gene_expression (Effect) of IL-12
11) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.89 Pain Relevance 0.45
Unstimulated H-PBMCs (n = 12) were cultured for 7 days with or without IL-12 and IL-18 alone and in combination with or without IL-18BP, and IFN-?
Neg (without) Gene_expression (without) of IL-12
12) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.20 Pain Relevance 0.10
While exogenous IL-18 showed a synergistic effect with IL-12 on IFN-?
Gene_expression (effect) of IL-12
13) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.67 Pain Relevance 0.33
IL-12 induced significant levels of IFN-?
Gene_expression (levels) of IL-12
14) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.34 Pain Relevance 0.17
To further explore this contrast, total RA synovial cells (n = 7), obtained after collagenase digestion, were exposed to IL-12 and IL-18 using the same conditions as were used with the PBMCs (Fig. 3a).
Gene_expression (exposed) of IL-12 in synovial cells associated with rheumatoid arthritis
15) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.28 Pain Relevance 0.57
As shown in Fig. 2a (white bars), IL-12-stimulated IFN-?
Gene_expression (shown) of IL-12-stimulated in bars
16) Confidence 0.44 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.44 Pain Relevance 0.22
To investigate whether heroin use or heroin use plus HCV infection has an impact on IL-12 pathway in CD56+ T cells, the transcriptional expression of key elements [IL-12 receptors, signal transducer and activator of transcription (STAT)-1, 3, 4, 5, janus kinase (JAK)-2, and tyrosine kinase (TYK)-2] in IL-12 pathway in CD56+ T cells was analyzed by the real-time RT PCR.
Gene_expression (expression) of IL-12 in T cells associated with hepatitis c virus infection, opiate addiction and infection
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.22 Pain Relevance 0
We first examined the gene expression of IL-12 R?
Spec (examined) Gene_expression (expression) of IL-12
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.83 Pain Relevance 0
production with or without IL-12 and IL-18 alone or in combination.
Gene_expression (production) of IL-12
19) Confidence 0.40 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0 Pain Relevance 0
In fact, LDR0723 favoured production of IL-12 rather than of IFN-?
Gene_expression (favoured) of IL-12
20) Confidence 0.38 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.54 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox